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TLDC2 TBC/LysM-associated domain containing 2 [ Homo sapiens (human) ]

Gene ID: 140711, updated on 4-Jun-2020

Summary

Official Symbol
TLDC2provided by HGNC
Official Full Name
TBC/LysM-associated domain containing 2provided by HGNC
Primary source
HGNC:HGNC:16112
See related
Ensembl:ENSG00000101342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf118
Expression
Ubiquitous expression in appendix (RPKM 10.6), small intestine (RPKM 8.5) and 25 other tissues See more
Orthologs

Genomic context

See TLDC2 in Genome Data Viewer
Location:
20q11.23
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (36873071..36894235)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (35504570..35522632)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene suppressor of glucose, autophagy associated 1 Neighboring gene RNA, 7SL, cytoplasmic 156, pseudogene Neighboring gene SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 Neighboring gene RB transcriptional corepressor like 1 Neighboring gene RPS3A pseudogene 3 Neighboring gene RPS27A pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
negative regulation of oxidative stress-induced neuron death IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
TLD domain-containing protein 2
Names
TBC/LysM-associated domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304783.1NP_001291712.1  TLD domain-containing protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AI537606, AK123544, BC127688, BG163960, BY994247
    UniProtKB/Swiss-Prot
    A0PJX2
    Conserved Domains (1) summary
    smart00584
    Location:53180
    TLDc; domain in TBC and LysM domain containing proteins
  2. NM_080628.3NP_542195.1  TLD domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_542195.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI537606, AK123544, AL079335, BC127688
    Consensus CDS
    CCDS33465.1
    UniProtKB/Swiss-Prot
    A0PJX2
    Related
    ENSP00000217320.3, ENST00000217320.8
    Conserved Domains (1) summary
    smart00584
    Location:53212
    TLDc; domain in TBC and LysM domain containing proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    36873071..36894235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027673.1XP_016883162.1  TLD domain-containing protein 2 isoform X2

    Conserved Domains (1) summary
    smart00584
    Location:53180
    TLDc; domain in TBC and LysM domain containing proteins
  2. XM_017027672.1XP_016883161.1  TLD domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A0PJX2
    Related
    ENSP00000473323.1, ENST00000602922.5
    Conserved Domains (1) summary
    smart00584
    Location:53212
    TLDc; domain in TBC and LysM domain containing proteins
  3. XM_017027674.1XP_016883163.1  TLD domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    smart00584
    Location:1116
    TLDc; domain in TBC and LysM domain containing proteins

RNA

  1. XR_001754176.1 RNA Sequence

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