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Emid1 EMI domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 140703, updated on 2-Nov-2024

Summary

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Official Symbol
Emid1provided by MGI
Official Full Name
EMI domain containing 1provided by MGI
Primary source
MGI:MGI:2155091
See related
Ensembl:ENSMUSG00000034164 AllianceGenome:MGI:2155091
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CO-5; Emu1
Summary
Predicted to be an extracellular matrix structural constituent. Located in Golgi apparatus; endoplasmic reticulum; and extracellular matrix. Is expressed in brain; branchial groove; genitourinary system; neural tube; and sensory organ. Orthologous to human EMID1 (EMI domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in genital fat pad adult (RPKM 13.0), bladder adult (RPKM 8.3) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Emid1 in Genome Data Viewer
Location:
11 A1; 11 3.26 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (5056265..5102322, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (5106265..5152322, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene growth arrest-specific 2 like 1 Neighboring gene RAS-like, family 10, member A Neighboring gene Ewing sarcoma breakpoint region 1 Neighboring gene STARR-positive B cell enhancer ABC_E8383 Neighboring gene STARR-positive B cell enhancer ABC_E11468 Neighboring gene rhomboid domain containing 3 Neighboring gene predicted gene, 46266 Neighboring gene predicted gene, 39572 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:5050795-5051007 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:5076723-5076924 Neighboring gene STARR-positive B cell enhancer ABC_E11763 Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene kringle containing transmembrane protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:5115988-5116097 Neighboring gene predicted gene, 25142

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Developmental expression and biochemical characterization of Emu family members. Leimeister C, et al. Dev Biol, 2002 Sep 15. PMID 12221002
  2. Screen for genes regulated during early kidney morphogenesis. Leimeister C, et al. Dev Genet, 1999. PMID 10322635
  3. Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis. Sampath Kumar A, et al. Nat Genet, 2023 Jul. PMID 37414952, Free PMC Article
  4. The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Naba A, et al. Mol Cell Proteomics, 2012 Apr. PMID 22159717, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
located_in collagen-containing extracellular matrix HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
EMI domain-containing protein 1
Names
emilin and multimerin domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371000.1 → NP_001357929.1  EMI domain-containing protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL645845
    Conserved Domains (2) summary
    pfam01391
    Location:318 → 370
    Collagen; Collagen triple helix repeat (20 copies)
    pfam07546
    Location:35 → 100
    EMI; EMI domain

  2. NM_001371001.1 → NP_001357930.1  EMI domain-containing protein 1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL645845
    Conserved Domains (2) summary
    pfam01391
    Location:316 → 368
    Collagen; Collagen triple helix repeat (20 copies)
    pfam07546
    Location:35 → 98
    EMI; EMI domain

  3. NM_001371002.1 → NP_001357931.1  EMI domain-containing protein 1 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AL645845
    Conserved Domains (2) summary
    pfam01391
    Location:318 → 370
    Collagen; Collagen triple helix repeat (20 copies)
    pfam07546
    Location:35 → 100
    EMI; EMI domain

  4. NM_001371003.1 → NP_001357932.1  EMI domain-containing protein 1 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AL645845
    Consensus CDS
    CCDS88125.1
    Related
    ENSMUSP00000131391.2, ENSMUST00000163299.8
    Conserved Domains (2) summary
    pfam01391
    Location:316 → 368
    Collagen; Collagen triple helix repeat (20 copies)
    pfam07546
    Location:35 → 98
    EMI; EMI domain

  5. NM_001371004.1 → NP_001357933.1  EMI domain-containing protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL645845
    Conserved Domains (2) summary
    pfam01391
    Location:253 → 305
    Collagen; Collagen triple helix repeat (20 copies)
    pfam07546
    Location:2 → 35
    EMI; EMI domain

  6. NM_001371005.1 → NP_001357934.1  EMI domain-containing protein 1 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AL645845
    Conserved Domains (2) summary
    pfam01391
    Location:257 → 309
    Collagen; Collagen triple helix repeat (20 copies)
    pfam07546
    Location:35 → 100
    EMI; EMI domain

  7. NM_080595.3 → NP_542162.1  EMI domain-containing protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_542162.1

    Status: VALIDATED

    Source sequence(s)
    AL645845
    Consensus CDS
    CCDS24398.1
    UniProtKB/Swiss-Prot
    Q91VF5
    UniProtKB/TrEMBL
    Q5SUT2
    Related
    ENSMUSP00000061704.6, ENSMUST00000062821.13
    Conserved Domains (2) summary
    pfam01391
    Location:318 → 370
    Collagen; Collagen triple helix repeat (20 copies)
    pfam07546
    Location:35 → 100
    EMI; EMI domain

RNA

  1. NR_152138.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL645845

  2. NR_163830.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL645845

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    5056265..5102322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514521.5 → XP_006514584.1  EMI domain-containing protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006514584.1

    Conserved Domains (1) summary
    pfam01391
    Location:233 → 285
    Collagen; Collagen triple helix repeat (20 copies)

  2. XM_030245552.2 → XP_030101412.1  EMI domain-containing protein 1 isoform X4

    Conserved Domains (1) summary
    pfam01391
    Location:233 → 285
    Collagen; Collagen triple helix repeat (20 copies)

  3. XM_030245553.1 → XP_030101413.1  EMI domain-containing protein 1 isoform X6

    Conserved Domains (1) summary
    pfam01391
    Location:172 → 224
    Collagen; Collagen triple helix repeat (20 copies)

  4. XM_006514522.5 → XP_006514585.1  EMI domain-containing protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006514585.1

    Conserved Domains (1) summary
    pfam01391
    Location:233 → 285
    Collagen; Collagen triple helix repeat (20 copies)

  5. XM_006514524.2 → XP_006514587.1  EMI domain-containing protein 1 isoform X5

    Conserved Domains (1) summary
    pfam01391
    Location:198 → 250
    Collagen; Collagen triple helix repeat (20 copies)

  6. XM_036156325.1 → XP_036012218.1  EMI domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    pfam01391
    Location:321 → 370
    Collagen; Collagen triple helix repeat (20 copies)
    pfam07546
    Location:35 → 100
    EMI; EMI domain

  7. XM_011243663.3 → XP_011241965.1  EMI domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011241965.1

    Conserved Domains (2) summary
    pfam01391
    Location:318 → 370
    Collagen; Collagen triple helix repeat (20 copies)
    pfam07546
    Location:35 → 100
    EMI; EMI domain

RNA

  1. XR_004936745.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VF5.1 GenPept UniProtKB/Swiss-Prot:Q91VF5

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