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CBLN4 cerebellin 4 precursor [ Homo sapiens (human) ]

Gene ID: 140689, updated on 29-Mar-2020

Summary

Official Symbol
CBLN4provided by HGNC
Official Full Name
cerebellin 4 precursorprovided by HGNC
Primary source
HGNC:HGNC:16231
See related
Ensembl:ENSG00000054803 MIM:615029
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBLNL1
Summary
This gene encodes a member of a family of small secreted proteins containing C1Q domains. Members of this family are involved in regulation of neurexin signalling during synapse development. The mouse homolog of the protein encoded by this gene competes with netrin to bind to the deleted in colorectal cancer receptor. [provided by RefSeq, Aug 2012]
Expression
Biased expression in adrenal (RPKM 11.4), brain (RPKM 6.3) and 3 other tissues See more
Orthologs

Genomic context

See CBLN4 in Genome Data Viewer
Location:
20q13.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (55997357..56005519, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (54572413..54580528, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372677 Neighboring gene uncharacterized LOC105372678 Neighboring gene uncharacterized LOC105372679 Neighboring gene uncharacterized LOC105376989

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
inhibitory synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
protein secretion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
GABA-ergic synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
collagen-containing extracellular matrix HDA PubMed 
extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cerebellin-4
Names
cerebellin precursor-like 1
cerebellin-like glycoprotein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080617.6NP_542184.1  cerebellin-4 precursor

    See identical proteins and their annotated locations for NP_542184.1

    Status: REVIEWED

    Source sequence(s)
    AK289640, AL117383, AY358527, DA137489, DA391781
    Consensus CDS
    CCDS13448.1
    UniProtKB/Swiss-Prot
    Q9NTU7
    Related
    ENSP00000064571.2, ENST00000064571.3
    Conserved Domains (1) summary
    cl23878
    Location:70201
    C1q; C1q domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    55997357..56005519 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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