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Eya4 EYA transcriptional coactivator and phosphatase 4 [ Mus musculus (house mouse) ]

Gene ID: 14051, updated on 8-Feb-2024

Summary

Official Symbol
Eya4provided by MGI
Official Full Name
EYA transcriptional coactivator and phosphatase 4provided by MGI
Primary source
MGI:MGI:1337104
See related
Ensembl:ENSMUSG00000010461 AllianceGenome:MGI:1337104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B130023L16Rik
Summary
Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within middle ear morphogenesis and sensory perception of sound. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; limb bud; sensory organ; and urinary system. Used to study otitis media. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 10; congestive heart failure; dilated cardiomyopathy; dilated cardiomyopathy 1J; and sensorineural hearing loss. Orthologous to human EYA4 (EYA transcriptional coactivator and phosphatase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 8.2), limb E14.5 (RPKM 3.1) and 7 other tissues See more
Orthologs
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Genomic context

See Eya4 in Genome Data Viewer
Location:
10 A3; 10 10.44 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (22978861..23226785, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (23102962..23350838, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26037 Neighboring gene predicted gene, 35126 Neighboring gene predicted gene, 35179 Neighboring gene STARR-seq mESC enhancer starr_26038 Neighboring gene STARR-seq mESC enhancer starr_26039 Neighboring gene STARR-seq mESC enhancer starr_26040 Neighboring gene predicted gene, 24655 Neighboring gene STARR-seq mESC enhancer starr_26042 Neighboring gene predicted gene, 53620 Neighboring gene STARR-seq mESC enhancer starr_26043 Neighboring gene predicted gene, 47843 Neighboring gene STARR-seq mESC enhancer starr_26044 Neighboring gene STARR-seq mESC enhancer starr_26045 Neighboring gene STARR-seq mESC enhancer starr_26046 Neighboring gene predicted gene, 35291

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within middle ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
eyes absent homolog 4
Names
eyes absent 4 homolog
NP_001334301.1
NP_034297.2
XP_006512592.1
XP_017169288.1
XP_030100738.1
XP_030100739.1
XP_030100740.1
XP_036011486.1
XP_036011487.1
XP_036011488.1
XP_036011489.1
XP_036011490.1
XP_036011491.1
XP_036011492.1
XP_036011493.1
XP_036011494.1
XP_036011495.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347372.1NP_001334301.1  eyes absent homolog 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a shorter 5' UTR and uses an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is the same length, but contains a distinct internal segment compared to isoform 1.
    Source sequence(s)
    AA738596, AC113497, AK041625, AK045060, CD348600
    Consensus CDS
    CCDS83687.1
    UniProtKB/Swiss-Prot
    Q0VAV8, Q9Z191
    Related
    ENSMUSP00000151287.2, ENSMUST00000220299.2
    Conserved Domains (2) summary
    PTZ00395
    Location:139318
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:345616
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  2. NM_010167.5NP_034297.2  eyes absent homolog 4 isoform 1

    See identical proteins and their annotated locations for NP_034297.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC113497, AC153551, AK041625, AK045060
    Consensus CDS
    CCDS35867.1
    UniProtKB/TrEMBL
    Q8BY78
    Related
    ENSMUSP00000090335.5, ENSMUST00000092665.12
    Conserved Domains (2) summary
    PTZ00395
    Location:139318
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:345616
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    22978861..23226785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155597.1XP_036011490.1  eyes absent homolog 4 isoform X2

    UniProtKB/TrEMBL
    A0A1W2P721
    Conserved Domains (2) summary
    PTZ00395
    Location:162341
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:368639
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  2. XM_036155601.1XP_036011494.1  eyes absent homolog 4 isoform X5

    UniProtKB/TrEMBL
    Q8BY78
    Conserved Domains (2) summary
    PTZ00395
    Location:139318
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:345616
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  3. XM_036155598.1XP_036011491.1  eyes absent homolog 4 isoform X2

    UniProtKB/TrEMBL
    A0A1W2P721
    Conserved Domains (2) summary
    PTZ00395
    Location:162341
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:368639
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  4. XM_036155596.1XP_036011489.1  eyes absent homolog 4 isoform X1

    Conserved Domains (2) summary
    PTZ00395
    Location:162341
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:368639
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  5. XM_036155594.1XP_036011487.1  eyes absent homolog 4 isoform X1

    Conserved Domains (2) summary
    PTZ00395
    Location:162341
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:368639
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  6. XM_036155602.1XP_036011495.1  eyes absent homolog 4 isoform X9

    Conserved Domains (2) summary
    PTZ00395
    Location:3182
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:209480
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  7. XM_017313799.2XP_017169288.1  eyes absent homolog 4 isoform X2

    UniProtKB/TrEMBL
    A0A1W2P721
    Related
    ENSMUSP00000151483.2, ENSMUST00000219315.2
    Conserved Domains (2) summary
    PTZ00395
    Location:162341
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:368639
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  8. XM_036155595.1XP_036011488.1  eyes absent homolog 4 isoform X1

    Conserved Domains (2) summary
    PTZ00395
    Location:162341
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:368639
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  9. XM_036155593.1XP_036011486.1  eyes absent homolog 4 isoform X1

    Conserved Domains (2) summary
    PTZ00395
    Location:162341
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:368639
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  10. XM_030244880.2XP_030100740.1  eyes absent homolog 4 isoform X10

    Conserved Domains (2) summary
    PTZ00395
    Location:108287
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:314585
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  11. XM_006512529.5XP_006512592.1  eyes absent homolog 4 isoform X6

    Conserved Domains (2) summary
    PTZ00395
    Location:108287
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:314585
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  12. XM_030244878.2XP_030100738.1  eyes absent homolog 4 isoform X7

    Conserved Domains (2) summary
    PTZ00395
    Location:100279
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:306577
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  13. XM_030244879.2XP_030100739.1  eyes absent homolog 4 isoform X8

    Conserved Domains (2) summary
    PTZ00395
    Location:79258
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:285556
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  14. XM_036155599.1XP_036011492.1  eyes absent homolog 4 isoform X3

    Conserved Domains (2) summary
    PTZ00395
    Location:154333
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:360631
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  15. XM_036155600.1XP_036011493.1  eyes absent homolog 4 isoform X4

    Conserved Domains (2) summary
    PTZ00395
    Location:149328
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:355626
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

RNA

  1. XR_004936098.1 RNA Sequence