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Atp6v0a4 ATPase, H+ transporting, lysosomal V0 subunit A4 [ Mus musculus (house mouse) ]

Gene ID: 140494, updated on 8-Feb-2024

Summary

Official Symbol
Atp6v0a4provided by MGI
Official Full Name
ATPase, H+ transporting, lysosomal V0 subunit A4provided by MGI
Primary source
MGI:MGI:2153480
See related
Ensembl:ENSMUSG00000038600 AllianceGenome:MGI:2153480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
a4; Atp6n1b
Summary
Predicted to enable ATPase binding activity and P-type proton-exporting transporter activity. Acts upstream of or within proton transmembrane transport. Located in apical plasma membrane; brush border; and endosome. Part of vacuolar proton-transporting V-type ATPase complex. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; respiratory system; and sensory organ. Used to study renal tubular acidosis. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human ATP6V0A4 (ATPase H+ transporting V0 subunit a4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 61.8) and placenta adult (RPKM 4.2) See more
Orthologs
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Genomic context

See Atp6v0a4 in Genome Data Viewer
Location:
6 B1; 6 17.5 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (38025418..38101521, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (38048483..38124586, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene SV2 related protein homolog (rat)-like Neighboring gene vomeronasal 2, receptor 121 pseudogene Neighboring gene predicted gene, 33494 Neighboring gene predicted gene, 57763 Neighboring gene RIKEN cDNA D630045J12 gene Neighboring gene transmembrane protein 213 Neighboring gene predicted gene, 23231 Neighboring gene STARR-positive B cell enhancer mm9_chr6:38110166-38110466 Neighboring gene predicted gene, 52858 Neighboring gene STARR-seq mESC enhancer starr_15615 Neighboring gene predicted gene 7504

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables P-type proton-exporting transporter activity ISA
Inferred from Sequence Alignment
more info
PubMed 
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ossification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proton transmembrane transport IPI
Inferred from Physical Interaction
more info
PubMed 
acts_upstream_of_or_within proton transmembrane transport ISA
Inferred from Sequence Alignment
more info
PubMed 
involved_in proton transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of pH ISO
Inferred from Sequence Orthology
more info
 
involved_in renal tubular secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle lumen acidification EXP
Inferred from Experiment
more info
PubMed 
involved_in synaptic vesicle lumen acidification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle lumen acidification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vacuolar acidification IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of proton-transporting V-type ATPase, V0 domain IEA
Inferred from Electronic Annotation
more info
 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
part_of vacuolar proton-transporting V-type ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of vacuolar proton-transporting V-type ATPase complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of vacuolar proton-transporting V-type ATPase complex ISA
Inferred from Sequence Alignment
more info
PubMed 
part_of vacuolar proton-transporting V-type ATPase complex ISO
Inferred from Sequence Orthology
more info
 
part_of vacuolar proton-transporting V-type ATPase, V0 domain IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
V-type proton ATPase 116 kDa subunit a 4
Names
ATPase, H+ transporting, lysosomal (vacuolar proton pump) noncatalytic accessory protein 1B
V-ATPase 116 kDa
V-ATPase 116 kDa isoform a 4
V-ATPase alpha 4
V-type proton ATPase 116 kDa subunit a
vacuolar proton translocating ATPase 100 kDa a4 subunit
NP_536715.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080467.3NP_536715.3  V-type proton ATPase 116 kDa subunit a 4

    See identical proteins and their annotated locations for NP_536715.3

    Status: VALIDATED

    Source sequence(s)
    AK143790, BC046979
    Consensus CDS
    CCDS20010.1
    UniProtKB/Swiss-Prot
    Q8CJ79, Q920B5, Q920R6
    Related
    ENSMUSP00000039381.5, ENSMUST00000040259.8
    Conserved Domains (2) summary
    COG1269
    Location:28824
    NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
    pfam01496
    Location:28823
    V_ATPase_I; V-type ATPase 116kDa subunit family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    38025418..38101521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)