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Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 [ Mus musculus (house mouse) ]

Gene ID: 140488, updated on 22-Jan-2023

Summary

Official Symbol
Igf2bp3provided by MGI
Official Full Name
insulin-like growth factor 2 mRNA binding protein 3provided by MGI
Primary source
MGI:MGI:1890359
See related
Ensembl:ENSMUSG00000029814 AllianceGenome:MGI:1890359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IMP3; IMP-3; Koc13; mimp3; Neilsen; 2610101N11Rik
Summary
Predicted to enable mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Predicted to be involved in nervous system development; regulation of RNA metabolic process; and regulation of gene expression. Predicted to act upstream of or within mRNA transport and regulation of translation. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including central nervous system; early conceptus; gonad; liver; and sensory organ. Orthologous to human IGF2BP3 (insulin like growth factor 2 mRNA binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 14.8), testis adult (RPKM 10.2) and 8 other tissues See more
Orthologs
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Genomic context

See Igf2bp3 in Genome Data Viewer
Location:
6 B2.3; 6 23.82 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (49062152..49200225, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (49085218..49215469, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene mitochondrial assembly of ribosomal large subunit 1 Neighboring gene predicted gene 7890 Neighboring gene predicted gene, 18010 Neighboring gene RIKEN cDNA D030074P21 gene Neighboring gene transformer 2 alpha Neighboring gene ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC61294

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N6-methyladenosine-containing RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 5'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in CRD-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
insulin-like growth factor 2 mRNA-binding protein 3
Names
IGF-II mRNA-binding protein 3
IGF2 mRNA-binding protein 3
VICKZ family member 3
insulin-like growth factor 2, binding protein 3
mIMP-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023670.3NP_076159.3  insulin-like growth factor 2 mRNA-binding protein 3

    See identical proteins and their annotated locations for NP_076159.3

    Status: VALIDATED

    Source sequence(s)
    AK147140, BC045138, CB524241
    Consensus CDS
    CCDS39485.1
    UniProtKB/Swiss-Prot
    Q8C2J9, Q9CPN8
    UniProtKB/TrEMBL
    A0A8C6HPZ8
    Related
    ENSMUSP00000031838.8, ENSMUST00000031838.9
    Conserved Domains (4) summary
    cd00105
    Location:279344
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:407470
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    cd12630
    Location:81156
    RRM2_IGF2BP3; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
    cl17169
    Location:177
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    49062152..49200225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255148.2XP_030111008.1  insulin-like growth factor 2 mRNA-binding protein 3 isoform X2

    Conserved Domains (3) summary
    cd00105
    Location:1681
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:144207
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:229292
    KH_1; KH domain
  2. XM_006505517.4XP_006505580.1  insulin-like growth factor 2 mRNA-binding protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C6HNL7
    Conserved Domains (5) summary
    cd00105
    Location:238303
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:366429
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    cd12630
    Location:40115
    RRM2_IGF2BP3; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
    pfam00013
    Location:451514
    KH_1; KH domain
    cl17169
    Location:1636
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_006505519.4XP_006505582.1  insulin-like growth factor 2 mRNA-binding protein 3 isoform X2

    Conserved Domains (3) summary
    cd00105
    Location:1681
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:144207
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:229292
    KH_1; KH domain

RNA

  1. XR_377421.5 RNA Sequence