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ASB9 ankyrin repeat and SOCS box containing 9 [ Homo sapiens (human) ]

Gene ID: 140462, updated on 5-Jul-2020

Summary

Official Symbol
ASB9provided by HGNC
Official Full Name
ankyrin repeat and SOCS box containing 9provided by HGNC
Primary source
HGNC:HGNC:17184
See related
Ensembl:ENSG00000102048 MIM:300890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin ligase complexes. They may function to mediate the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Expression
Biased expression in testis (RPKM 16.8), kidney (RPKM 5.8) and 8 other tissues See more
Orthologs

Genomic context

See ASB9 in Genome Data Viewer
Location:
Xp22.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (15243987..15270476, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (15262109..15288589, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35a pseudogene 37 Neighboring gene uncharacterized LOC102724092 Neighboring gene ankyrin repeat and SOCS box containing 11 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4954, FLJ20636, DKFZp564L0862

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ankyrin repeat and SOCS box protein 9
Names
ASB-9
ankyrin repeat and suppressor of cytokine signaling box protein 9
testis tissue sperm-binding protein Li 57p

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016218.1 RefSeqGene

    Range
    5385..31481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001031739.3NP_001026909.1  ankyrin repeat and SOCS box protein 9 isoform 1

    See identical proteins and their annotated locations for NP_001026909.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC001244, BC013172, DA943920
    Consensus CDS
    CCDS35208.1
    UniProtKB/Swiss-Prot
    Q96DX5
    UniProtKB/TrEMBL
    A0A024RBW7
    Related
    ENSP00000369855.4, ENST00000380488.9
    Conserved Domains (4) summary
    cd00204
    Location:63187
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03728
    Location:253294
    SOCS_ASB_9_11; SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    sd00045
    Location:3566
    ANK; ANK repeat [structural motif]
    cl26073
    Location:147235
    Ank_2; Ankyrin repeats (3 copies)
  2. NM_001168530.2NP_001162002.1  ankyrin repeat and SOCS box protein 9 isoform 3

    See identical proteins and their annotated locations for NP_001162002.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites in the coding region, one of which results in a frameshift, compared to variant 1. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC001244, DA943920
    Consensus CDS
    CCDS55372.1
    UniProtKB/Swiss-Prot
    Q96DX5
    UniProtKB/TrEMBL
    A0A024RBZ4
    Related
    ENSP00000369850.3, ENST00000380483.7
    Conserved Domains (4) summary
    cd00204
    Location:37177
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:41128
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:159208
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:3566
    ANK; ANK repeat [structural motif]
  3. NM_001168531.1NP_001162003.1  ankyrin repeat and SOCS box protein 9 isoform 2

    See identical proteins and their annotated locations for NP_001162003.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1. Both variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AK292270, BC001244
    Consensus CDS
    CCDS14163.1
    UniProtKB/Swiss-Prot
    Q96DX5
    UniProtKB/TrEMBL
    A0A024RBW2
    Related
    ENSP00000438943.1, ENST00000546332.1
    Conserved Domains (4) summary
    cd00204
    Location:63187
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:73163
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:3789
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:3566
    ANK; ANK repeat [structural motif]
  4. NM_024087.3NP_076992.1  ankyrin repeat and SOCS box protein 9 isoform 2

    See identical proteins and their annotated locations for NP_076992.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1. Both variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AK000643, BC001244, DA943920
    Consensus CDS
    CCDS14163.1
    UniProtKB/Swiss-Prot
    Q96DX5
    UniProtKB/TrEMBL
    A0A024RBW2
    Related
    ENSP00000369852.3, ENST00000380485.7
    Conserved Domains (4) summary
    cd00204
    Location:63187
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:73163
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:3789
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:3566
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    15243987..15270476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029284.1XP_016884773.1  ankyrin repeat and SOCS box protein 9 isoform X2

  2. XM_024452341.1XP_024308109.1  ankyrin repeat and SOCS box protein 9 isoform X4

    Conserved Domains (3) summary
    cd00204
    Location:120241
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:190218
    ANK; ANK repeat [structural motif]
    cl26073
    Location:201289
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_017029283.1XP_016884772.1  ankyrin repeat and SOCS box protein 9 isoform X1

  4. XM_017029285.1XP_016884774.1  ankyrin repeat and SOCS box protein 9 isoform X3

  5. XM_017029286.2XP_016884775.1  ankyrin repeat and SOCS box protein 9 isoform X3

  6. XM_011545458.1XP_011543760.1  ankyrin repeat and SOCS box protein 9 isoform X6

    Conserved Domains (5) summary
    cd00204
    Location:37158
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03728
    Location:224265
    SOCS_ASB_9_11; SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    pfam12796
    Location:73166
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:3789
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:107135
    ANK; ANK repeat [structural motif]
  7. XM_011545460.1XP_011543762.1  ankyrin repeat and SOCS box protein 9 isoform X7

    See identical proteins and their annotated locations for XP_011543762.1

    Conserved Domains (4) summary
    cd00204
    Location:37158
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:73166
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:3789
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:107135
    ANK; ANK repeat [structural motif]
  8. XM_005274446.1XP_005274503.1  ankyrin repeat and SOCS box protein 9 isoform X5

    See identical proteins and their annotated locations for XP_005274503.1

    UniProtKB/Swiss-Prot
    Q96DX5
    UniProtKB/TrEMBL
    A0A024RBW7
    Conserved Domains (4) summary
    cd00204
    Location:63187
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03728
    Location:253294
    SOCS_ASB_9_11; SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    sd00045
    Location:3566
    ANK; ANK repeat [structural motif]
    cl26073
    Location:147235
    Ank_2; Ankyrin repeats (3 copies)
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