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Wfdc18 WAP four-disulfide core domain 18 [ Mus musculus (house mouse) ]

Gene ID: 14038, updated on 8-Feb-2024

Summary

Official Symbol
Wfdc18provided by MGI
Official Full Name
WAP four-disulfide core domain 18provided by MGI
Primary source
MGI:MGI:107506
See related
Ensembl:ENSMUSG00000000983 AllianceGenome:MGI:107506
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Expi; Kal1; WDNM1
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in antibacterial humoral response and innate immune response. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in mammary gland. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 18.3), thymus adult (RPKM 11.0) and 4 other tissues See more
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Genomic context

See Wfdc18 in Genome Data Viewer
Location:
11 C; 11 51.23 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83599830..83602186)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83709004..83711360)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11430 Neighboring gene WAP four-disulfide core domain 17 Neighboring gene STARR-positive B cell enhancer ABC_E3982 Neighboring gene STARR-positive B cell enhancer ABC_E9834 Neighboring gene WAP four-disulfide core domain 21 Neighboring gene HEAT repeat containing 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
WAP four-disulfide core domain protein 18
Names
Kallmann syndrome 1 sequence
extracellular peptidase inhibitor
extracellular proteinase inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007969.4NP_031995.3  WAP four-disulfide core domain protein 18 precursor

    See identical proteins and their annotated locations for NP_031995.3

    Status: VALIDATED

    Source sequence(s)
    EH099462, EH105860, EH109450
    Consensus CDS
    CCDS25175.1
    UniProtKB/Swiss-Prot
    P62810, Q91VQ6
    UniProtKB/TrEMBL
    Q3UMA2
    Related
    ENSMUSP00000001009.8, ENSMUST00000001009.14
    Conserved Domains (1) summary
    cd00199
    Location:1473
    WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    83599830..83602186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)