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Etv1 ets variant 1 [ Mus musculus (house mouse) ]

Gene ID: 14009, updated on 5-Mar-2024

Summary

Official Symbol
Etv1provided by MGI
Official Full Name
ets variant 1provided by MGI
Primary source
MGI:MGI:99254
See related
Ensembl:ENSMUSG00000004151 AllianceGenome:MGI:99254
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ER81; Etsrp81
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including axon guidance; mechanosensory behavior; and positive regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Orthologous to human ETV1 (ETS variant transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 13.2), frontal lobe adult (RPKM 4.0) and 9 other tissues See more
Orthologs
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Genomic context

See Etv1 in Genome Data Viewer
Location:
12 A3; 12 17.99 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (38829655..38920484)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (38780082..38870483)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase, beta Neighboring gene RIKEN cDNA 4930428E07 gene Neighboring gene STARR-seq mESC enhancer starr_31937 Neighboring gene STARR-seq mESC enhancer starr_31938 Neighboring gene STARR-seq mESC enhancer starr_31940 Neighboring gene phosphatidylethanolamine binding protein 2 pseudogene Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene predicted gene, 34611

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ETS translocation variant 1
Names
ets variant gene 1
ets-related protein 81

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163154.1NP_001156626.1  ETS translocation variant 1 isoform b

    See identical proteins and their annotated locations for NP_001156626.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter, 5' UTR, and 5' coding region, compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK032224, CD776508
    Consensus CDS
    CCDS49054.1
    UniProtKB/TrEMBL
    E0CYN8, Q8CCR6
    Related
    ENSMUSP00000125676.2, ENSMUST00000159334.8
    Conserved Domains (2) summary
    smart00413
    Location:294378
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:21293
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  2. NM_001347379.1NP_001334308.1  ETS translocation variant 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (c) has the same N- and C-termini, but is shorter than isoform a.
    Source sequence(s)
    AK032224, AK035914, BB751428, CD776508, CT009742
    Consensus CDS
    CCDS83959.1
    UniProtKB/TrEMBL
    E0CZ54
    Related
    ENSMUSP00000125692.2, ENSMUST00000160856.8
  3. NM_007960.5NP_031986.1  ETS translocation variant 1 isoform a

    See identical proteins and their annotated locations for NP_031986.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK032224, AK035914, BB751428, CD776508, CT009742
    Consensus CDS
    CCDS49053.1
    UniProtKB/Swiss-Prot
    P41164
    UniProtKB/TrEMBL
    Q549J8
    Related
    ENSMUSP00000093442.4, ENSMUST00000095767.11
    Conserved Domains (2) summary
    smart00413
    Location:334418
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:3333
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    38829655..38920484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514968.5XP_006515031.1  ETS translocation variant 1 isoform X4

    See identical proteins and their annotated locations for XP_006515031.1

    UniProtKB/TrEMBL
    E0CYN8, Q8CCR6
    Conserved Domains (2) summary
    smart00413
    Location:294378
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:21293
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  2. XM_006514965.4XP_006515028.1  ETS translocation variant 1 isoform X2

    See identical proteins and their annotated locations for XP_006515028.1

    UniProtKB/Swiss-Prot
    P41164
    UniProtKB/TrEMBL
    Q549J8
    Conserved Domains (2) summary
    smart00413
    Location:334418
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:3333
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  3. XM_036157184.1XP_036013077.1  ETS translocation variant 1 isoform X4

    UniProtKB/TrEMBL
    E0CYN8, Q8CCR6
    Conserved Domains (2) summary
    smart00413
    Location:294378
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:21293
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  4. XM_006514964.5XP_006515027.1  ETS translocation variant 1 isoform X1

    Conserved Domains (2) summary
    smart00413
    Location:350434
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:31349
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  5. XM_036157185.1XP_036013078.1  ETS translocation variant 1 isoform X4

    UniProtKB/TrEMBL
    E0CYN8, Q8CCR6
    Conserved Domains (2) summary
    smart00413
    Location:294378
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:21293
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  6. XM_006514966.5XP_006515029.1  ETS translocation variant 1 isoform X3

    Conserved Domains (2) summary
    smart00413
    Location:332416
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:31331
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  7. XM_036157186.1XP_036013079.1  ETS translocation variant 1 isoform X7

    UniProtKB/TrEMBL
    E0CXD2, E0CYN8
    Related
    ENSMUSP00000124736.2, ENSMUST00000161980.8
    Conserved Domains (2) summary
    smart00413
    Location:276360
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:21275
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  8. XM_006514972.5XP_006515035.1  ETS translocation variant 1 isoform X8

    Conserved Domains (2) summary
    smart00413
    Location:203287
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:4202
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  9. XM_006514970.5XP_006515033.1  ETS translocation variant 1 isoform X6

    UniProtKB/TrEMBL
    E0CYN8
    Conserved Domains (2) summary
    smart00413
    Location:278362
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:2277
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
  10. XM_006514969.5XP_006515032.1  ETS translocation variant 1 isoform X5

    Conserved Domains (2) summary
    smart00413
    Location:279363
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:24278
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain