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Etv2 ets variant 2 [ Mus musculus (house mouse) ]

Gene ID: 14008, updated on 14-May-2024

Summary

Official Symbol
Etv2provided by MGI
Official Full Name
ets variant 2provided by MGI
Primary source
MGI:MGI:99253
See related
Ensembl:ENSMUSG00000006311 AllianceGenome:MGI:99253
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Etsrp71
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of endothelial cell differentiation; and positive regulation of mesoderm development. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system and hemolymphoid system. Orthologous to human ETV2 (ETS variant transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 3.1) See more
Orthologs
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Genomic context

See Etv2 in Genome Data Viewer
Location:
7 B1; 7 18.92 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30333041..30335934, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30633616..30636509, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18526 Neighboring gene uroplakin 1A Neighboring gene cytochrome c oxidase, subunit 6B1 Neighboring gene STARR-positive B cell enhancer ABC_E2232 Neighboring gene STARR-seq mESC enhancer starr_18529 Neighboring gene RNA binding motif protein 42 Neighboring gene STARR-positive B cell enhancer ABC_E545 Neighboring gene STARR-seq mESC enhancer starr_18530 Neighboring gene HAUS augmin-like complex, subunit 5 Neighboring gene STARR-positive B cell enhancer ABC_E6533

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within blastocyst development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemopoiesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesoderm formation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of endothelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of mesoderm development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ETS translocation variant 2
Names
ets variant gene 2
ets-related protein 71

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007959.2NP_031985.2  ETS translocation variant 2

    See identical proteins and their annotated locations for NP_031985.2

    Status: VALIDATED

    Source sequence(s)
    AB221612, BX638426, L10427
    Consensus CDS
    CCDS39888.1
    UniProtKB/Swiss-Prot
    F8VQ08, P41163
    Related
    ENSMUSP00000103782.3, ENSMUST00000108147.3
    Conserved Domains (1) summary
    smart00413
    Location:233315
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    30333041..30335934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539542.2XP_006539605.1  ETS translocation variant 2 isoform X2

    Conserved Domains (1) summary
    smart00413
    Location:255337
    ETS; erythroblast transformation specific domain
  2. XM_006539541.2XP_006539604.1  ETS translocation variant 2 isoform X1

    See identical proteins and their annotated locations for XP_006539604.1

    UniProtKB/TrEMBL
    Q5EP41
    Conserved Domains (1) summary
    smart00413
    Location:256338
    ETS; erythroblast transformation specific domain