CRMP1 collapsin response mediator protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CRMP1provided by HGNC
Official Full Name: collapsin response mediator protein 1provided by HGNC
Primary source: HGNC:HGNC:2365
See related: Ensembl:ENSG00000072832 MIM:602462; AllianceGenome:HGNC:2365
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DRP1; DRP-1; CRMP-1; DPYSL1; ULIP-3
Summary: This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 34.7), endometrium (RPKM 8.3) and 8 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4p16.2

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (5820764..5893086, complement)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (5792373..5864846, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (5822491..5894813, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Monoallelic CRMP1 gene variants cause neurodevelopmental disorder.
Title: Monoallelic CRMP1 gene variants cause neurodevelopmental disorder.
CRMP-1 might have implications for the pathogenesis of preeclampsia by regulating the biological behavior of trophoblast cells.
Title: Overexpression of Collapsin Response Mediator Protein 1 Inhibits Human Trophoblast Cells Proliferation, Migration, and Invasion.
Study provides a novel insight into the relevance of collapsin response mediator protein 1, a key molecule in semaphorin-3A signaling during neurodevelopment, in the molecular mechanism of action of lithium, and in the pathophysiology of bipolar disorder.
Title: Lithium-associated transcriptional regulation of CRMP1 in patient-derived olfactory neurons and symptom changes in bipolar disorder.
Study shows that CRMP1 acts an EMT and metastasis suppressor in prostate cancer cells via its regulation of actin polymerization.
Title: Collapsin response mediator protein-1 (CRMP1) acts as an invasion and metastasis suppressor of prostate cancer via its suppression of epithelial-mesenchymal transition and remodeling of actin cytoskeleton organization.
Identify CRMP-1 as a novel regulator of actin filament elongation and reveal a surprisingly important role for CRMP-1, EVL, and actin polymerization in maintaining the structural integrity of epithelial sheets.
Title: CRMP-1 enhances EVL-mediated actin elongation to build lamellipodia and the actin cortex.
The present study reports that miR-187 was significantly overexpressed in gastric cancer tissues compared to that in non-tumor tissues and was associated with malignant clinical factors such as depth of invasion (P = 0.005), tumor size (P = 0.024), lymph node metastasis . It was found that collapsin response mediator protein 1 (CRMP1), a tumor suppressor, was a direct downstream target of miR-187.
Title: MicroRNA-187 regulates gastric cancer progression by targeting the tumor suppressor CRMP1.
miR200a-3p promotes the proliferation of human esophageal cancer cells by post-transcriptionally regulating CRMP1.
Title: miR-200a-3p promotes the proliferation of human esophageal cancer cells by post-transcriptionally regulating cytoplasmic collapsin response mediator protein-1.
CRMP1 interacted with Spy1 which would disturb the association of CRMP1 with actin and was involved in the collapse of growth cones induced by Sema3A and regeneration after sciatic nerve crush.
Title: CRMP1 Interacted with Spy1 During the Collapse of Growth Cones Induced by Sema3A and Acted on Regeneration After Sciatic Nerve Crush.
These results demonstrate an important role for CRMP-1 in Listeria actin comet tail formation and open the possibility that CRMP-1 controls cell motility by modulating Arp2/3 activation.
Title: Collapsin Response Mediator Protein-1 Regulates Arp2/3-dependent Actin Assembly.
Human CRMP-1 comprises a tetrameric assembly.
Title: Structure of human collapsin response mediator protein 1: a possible role of its C-terminal tail.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4S3099 (e-PCR)
- UniSTS:25360

STS-R50561 (e-PCR)
- UniSTS:54348

SHGC-67720 (e-PCR)
- UniSTS:42077

SHGC-145187 (e-PCR)
- UniSTS:174435

WI-15614 (e-PCR)
- UniSTS:8551

SHGC-59173 (e-PCR)
- UniSTS:5736

Cda0ad03 (e-PCR)
- UniSTS:76150

RH47291 (e-PCR)
- UniSTS:76151

SHGC-59627 (e-PCR)
- UniSTS:46504

SHGC-67752 (e-PCR)
- UniSTS:82151

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
NOT enables dihydropyrimidinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables filamin binding	IPI Inferred from Physical Interaction more info	PubMed
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of actin filament binding	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of actin filament binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in nucleobase-containing compound metabolic process	TAS Traceable Author Statement more info	PubMed
NOT involved_in pyrimidine nucleobase catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dihydropyrimidinase-related protein 1

Names: dihydropyrimidinase-like 1; inactive dihydropyrimidinase; unc-33-like phosphoprotein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014809.3 → NP_001014809.1 dihydropyrimidinase-related protein 1 isoform 1

See identical proteins and their annotated locations for NP_001014809.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest protein (isoform 1).

Source sequence(s)

AC105915, AK094725, BC007898, DB498528

Consensus CDS

CCDS33950.1

UniProtKB/Swiss-Prot

Q14194

UniProtKB/TrEMBL

B3KT07, Q96I11, X5DNI1

Related

ENSP00000321606.7, ENST00000324989.12

Conserved Domains (2) summary

PRK09060
Location:131 → 581

PRK09060; dihydroorotase; Validated

cd01314
Location:131 → 580

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
NM_001288661.2 → NP_001275590.1 dihydropyrimidinase-related protein 1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate 5' exon, compared to variant 1. It differs in the 5' UTR and initiates translation at an alternate downstream AUG resulting in a protein (isoform 3) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

BC000252, BC007898, BC009987, DA184461

Consensus CDS

CCDS75102.1

UniProtKB/Swiss-Prot

Q14194

UniProtKB/TrEMBL

E9PD68, Q96I11

Related

ENSP00000425742.1, ENST00000512574.1

Conserved Domains (2) summary

PRK09060
Location:15 → 465

PRK09060; dihydroorotase; Validated

cd01314
Location:15 → 464

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
NM_001288662.1 → NP_001275591.1 dihydropyrimidinase-related protein 1 isoform 4

See identical proteins and their annotated locations for NP_001275591.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains an alternate 5' exon, compared to variant 1. It differs in the 5' UTR and initiates translation at an alternate downstream AUG resulting in a protein (isoform 4) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC105915, AK122754, BC000252, BC007898

UniProtKB/Swiss-Prot

Q14194

UniProtKB/TrEMBL

B3KV96, Q96I11

Related

ENST00000511535.1

Conserved Domains (2) summary

PRK09060
Location:11 → 461

PRK09060; dihydroorotase; Validated

cd01314
Location:11 → 460

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
NM_001313.5 → NP_001304.1 dihydropyrimidinase-related protein 1 isoform 2

See identical proteins and their annotated locations for NP_001304.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. It has a distinct 5' UTR and initiates translation at an alternate downstream AUG resulting in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

BC007613, BC007898, DA064850

Consensus CDS

CCDS43207.1

UniProtKB/Swiss-Prot

Q14194, Q96TC8

UniProtKB/TrEMBL

Q96I11

Related

ENSP00000380987.2, ENST00000397890.7

Conserved Domains (1) summary

cd01314
Location:17 → 466

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

5820764..5893086 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047449629.1 → XP_047305585.1 dihydropyrimidinase-related protein 1 isoform X1

UniProtKB/Swiss-Prot

Q96TC8
XM_047449630.1 → XP_047305586.1 dihydropyrimidinase-related protein 1 isoform X2

UniProtKB/TrEMBL

B3KT07

Alternate T2T-CHM13v2.0

Genomic

NC_060928.1 Alternate T2T-CHM13v2.0

Range

5792373..5864846 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054348967.1 → XP_054204942.1 dihydropyrimidinase-related protein 1 isoform X1

UniProtKB/Swiss-Prot

Q96TC8
XM_054348965.1 → XP_054204940.1 dihydropyrimidinase-related protein 1 isoform X3
XM_054348966.1 → XP_054204941.1 dihydropyrimidinase-related protein 1 isoform X4
XM_054348968.1 → XP_054204943.1 dihydropyrimidinase-related protein 1 isoform X5