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CRMP1 collapsin response mediator protein 1 [ Homo sapiens (human) ]

Gene ID: 1400, updated on 5-Aug-2018

Summary

Official Symbol
CRMP1provided by HGNC
Official Full Name
collapsin response mediator protein 1provided by HGNC
Primary source
HGNC:HGNC:2365
See related
Ensembl:ENSG00000072832 MIM:602462; Vega:OTTHUMG00000125489
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRP1; DRP-1; CRMP-1; DPYSL1; ULIP-3
Summary
This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 34.7), endometrium (RPKM 8.3) and 8 other tissues See more
Orthologs

Genomic context

See CRMP1 in Genome Data Viewer
Location:
4p16.2
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (5820764..5893083, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (5822491..5894785, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1587 Neighboring gene EvC ciliary complex subunit 2 Neighboring gene EvC ciliary complex subunit 1 Neighboring gene chromosome 4 open reading frame 50 Neighboring gene microRNA 378d-1 Neighboring gene janus kinase and microtubule interacting protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
NHGRI GWA Catalog

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • CRMPs in Sema3A signaling, organism-specific biosystem (from REACTOME)
    CRMPs in Sema3A signaling, organism-specific biosystemCRMPs are a small family of plexinA-interacting cytosolic phosphoproteins identified as mediators of Sema3A signaling and neuronal differentiation. After Sema3A activation Plexin-A bound CRMP's under...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Semaphorin interactions, organism-specific biosystem (from REACTOME)
    Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
filamin binding IPI
Inferred from Physical Interaction
more info
PubMed 
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
axon guidance IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of actin filament binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
nucleobase-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dihydropyrimidinase-related protein 1
Names
dihydropyrimidinase-like 1
unc-33-like phosphoprotein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014809.2NP_001014809.1  dihydropyrimidinase-related protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001014809.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AC105915, AK094725, BC007898, DB498528
    Consensus CDS
    CCDS33950.1
    UniProtKB/Swiss-Prot
    Q14194
    UniProtKB/TrEMBL
    B3KT07, Q96I11, X5DNI1
    Related
    ENSP00000321606.7, OTTHUMP00000155142, ENST00000324989.11, OTTHUMT00000246814
    Conserved Domains (2) summary
    PRK09060
    Location:131581
    PRK09060; dihydroorotase; Validated
    cd01314
    Location:131580
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
  2. NM_001288661.1NP_001275590.1  dihydropyrimidinase-related protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' exon, compared to variant 1. It differs in the 5' UTR and initiates translation at an alternate downstream AUG resulting in a protein (isoform 3) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC000252, BC007898, BC009987, DA184461
    Consensus CDS
    CCDS75102.1
    UniProtKB/Swiss-Prot
    Q14194
    UniProtKB/TrEMBL
    E9PD68, Q96I11
    Related
    ENSP00000425742.1, OTTHUMP00000217352, ENST00000512574.1, OTTHUMT00000358870
    Conserved Domains (2) summary
    PRK09060
    Location:15465
    PRK09060; dihydroorotase; Validated
    cd01314
    Location:15464
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
  3. NM_001288662.1NP_001275591.1  dihydropyrimidinase-related protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001275591.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' exon, compared to variant 1. It differs in the 5' UTR and initiates translation at an alternate downstream AUG resulting in a protein (isoform 4) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC105915, AK122754, BC000252, BC007898
    UniProtKB/Swiss-Prot
    Q14194
    UniProtKB/TrEMBL
    B3KV96, Q96I11
    Conserved Domains (2) summary
    PRK09060
    Location:11461
    PRK09060; dihydroorotase; Validated
    cd01314
    Location:11460
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
  4. NM_001313.4NP_001304.1  dihydropyrimidinase-related protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001304.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. It has a distinct 5' UTR and initiates translation at an alternate downstream AUG resulting in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC007613, BC007898, DA064850
    Consensus CDS
    CCDS43207.1
    UniProtKB/Swiss-Prot
    Q14194
    UniProtKB/TrEMBL
    Q96I11
    Related
    ENSP00000380987.2, OTTHUMP00000217353, ENST00000397890.6, OTTHUMT00000358871
    Conserved Domains (2) summary
    PLN02795
    Location:5460
    PLN02795; allantoinase
    cd01314
    Location:17466
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    5820764..5893083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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