U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gnb1l guanine nucleotide binding protein (G protein), beta polypeptide 1-like [ Mus musculus (house mouse) ]

Gene ID: 13972, updated on 18-Apr-2024

Summary

Official Symbol
Gnb1lprovided by MGI
Official Full Name
guanine nucleotide binding protein (G protein), beta polypeptide 1-likeprovided by MGI
Primary source
MGI:MGI:1338057
See related
Ensembl:ENSMUSG00000000884 AllianceGenome:MGI:1338057
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rtl10; Wdr14; Wdvcf; ESTM55; Gm16314; Me49f07
Summary
Acts upstream of or within social behavior. Located in cytoplasm. Is expressed in several structures, including brain; cardiovascular system; forelimb bud; fronto-nasal process; and hemolymphoid system gland. Orthologous to human GNB1L (G protein subunit beta 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 6.1), thymus adult (RPKM 3.8) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
16 A3; 16 11.46 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (18316029..18385430)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18497386..18566680)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15764 Neighboring gene catechol-O-methyltransferase Neighboring gene thioredoxin reductase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:18460133-18460376 Neighboring gene STARR-seq mESC enhancer starr_40284 Neighboring gene STARR-seq mESC enhancer starr_40285 Neighboring gene VISTA enhancer mm321 Neighboring gene Tbx1 upstream enhancer region Neighboring gene RIKEN cDNA 4930588K23 gene Neighboring gene predicted gene, 35369 Neighboring gene T-box 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein subunit beta-like protein 1
Names
WD repeat-containing protein 14
WD40 repeat-containing protein deleted in VCFS
g protein subunit beta-like protein 1
retrotransposon Gag like 10

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081682.2NP_001075151.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001075151.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC133488
    Consensus CDS
    CCDS28022.1
    UniProtKB/Swiss-Prot
    Q8R1F3, Q9CWP2, Q9D3Y1, Q9EQ15
    UniProtKB/TrEMBL
    Q3TBG5
    Related
    ENSMUSP00000156162.2, ENSMUST00000231621.2
    Conserved Domains (2) summary
    sd00039
    Location:2364
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:11321
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001285491.1NP_001272420.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an altenate splice site which results in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC133488, AK016952
    Conserved Domains (2) summary
    sd00039
    Location:108147
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:71219
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001285493.1NP_001272422.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001272422.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (3) is longer than isoform 1.
    Source sequence(s)
    AC133488, AK158210
    Consensus CDS
    CCDS88896.1
    UniProtKB/TrEMBL
    Q3TZ04
    Related
    ENSMUSP00000130371.3, ENSMUST00000167778.9
    Conserved Domains (2) summary
    sd00039
    Location:242281
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:11352
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_001285494.1NP_001272423.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001272423.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate splice site in the 3' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC133488
    Consensus CDS
    CCDS70695.1
    UniProtKB/TrEMBL
    Q3TBG5, Q3TM20
    Related
    ENSMUSP00000111264.2, ENSMUST00000115601.8
    Conserved Domains (3) summary
    COG2319
    Location:14308
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:2464
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:11307
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. NM_023120.5NP_075609.2  guanine nucleotide-binding protein subunit beta-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_075609.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1)
    Source sequence(s)
    AC133488
    Consensus CDS
    CCDS28022.1
    UniProtKB/Swiss-Prot
    Q8R1F3, Q9CWP2, Q9D3Y1, Q9EQ15
    UniProtKB/TrEMBL
    Q3TBG5
    Related
    ENSMUSP00000087544.5, ENSMUST00000090086.11
    Conserved Domains (2) summary
    sd00039
    Location:2364
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:11321
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_104347.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC133488

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    18316029..18385430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159780.1XP_036015673.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform X4

    UniProtKB/TrEMBL
    Q3TZ04
    Conserved Domains (2) summary
    sd00039
    Location:242281
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:11352
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_011245829.4XP_011244131.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011244131.1

    UniProtKB/TrEMBL
    Q3TZ04
    Conserved Domains (2) summary
    sd00039
    Location:242281
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:11352
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_011245832.4XP_011244134.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform X7

    See identical proteins and their annotated locations for XP_011244134.1

    Conserved Domains (2) summary
    sd00039
    Location:68107
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:31179
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_017316874.3XP_017172363.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform X7

    Conserved Domains (2) summary
    sd00039
    Location:68107
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:31179
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_030248975.1XP_030104835.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform X6

    Conserved Domains (2) summary
    sd00039
    Location:2364
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:11249
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_030248976.1XP_030104836.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:108147
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:71219
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. XM_011245831.1XP_011244133.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011244133.1

    UniProtKB/Swiss-Prot
    Q8R1F3, Q9CWP2, Q9D3Y1, Q9EQ15
    UniProtKB/TrEMBL
    Q3TBG5
    Conserved Domains (2) summary
    sd00039
    Location:2364
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:11321
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. XM_011245830.1XP_011244132.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011244132.1

    UniProtKB/TrEMBL
    Q3TZ04
    Conserved Domains (2) summary
    sd00039
    Location:242281
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:11352
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  9. XM_011245828.2XP_011244130.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011244130.1

    Conserved Domains (2) summary
    sd00039
    Location:285324
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:248396
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  10. XM_036159779.1XP_036015672.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:108147
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:71219
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  11. XM_030248974.1XP_030104834.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:83116
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:66147
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_003951760.2 RNA Sequence