Gnb1l guanine nucleotide binding protein (G protein), beta polypeptide 1-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gnb1lprovided by MGI
Official Full Name: guanine nucleotide binding protein (G protein), beta polypeptide 1-likeprovided by MGI
Primary source: MGI:MGI:1338057
See related: Ensembl:ENSMUSG00000000884 AllianceGenome:MGI:1338057
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rtl10; Wdr14; Wdvcf; ESTM55; Gm16314; Me49f07
Summary: Acts upstream of or within social behavior. Located in cytoplasm. Is expressed in several structures, including brain; cardiovascular system; forelimb bud; fronto-nasal process; and hemolymphoid system gland. Orthologous to human GNB1L (G protein subunit beta 1 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 6.1), thymus adult (RPKM 3.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 11.46 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (18316029..18385430)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (18497386..18566680)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1) 1 citation

General gene information

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Markers

Gnb1l (e-PCR), detects polymorphism
- UniSTS:256823

Gnb1l (e-PCR), detects polymorphism
- UniSTS:265711

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within social behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: guanine nucleotide-binding protein subunit beta-like protein 1

Names: WD repeat-containing protein 14; WD40 repeat-containing protein deleted in VCFS; g protein subunit beta-like protein 1; retrotransposon Gag like 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081682.2 → NP_001075151.1 guanine nucleotide-binding protein subunit beta-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_001075151.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AC133488

Consensus CDS

CCDS28022.1

UniProtKB/Swiss-Prot

Q8R1F3, Q9CWP2, Q9D3Y1, Q9EQ15

UniProtKB/TrEMBL

Q3TBG5

Related

ENSMUSP00000156162.2, ENSMUST00000231621.2

Conserved Domains (2) summary

sd00039
Location:23 → 64

7WD40; WD40 repeat [structural motif]

cl29593
Location:11 → 321

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001285491.1 → NP_001272420.1 guanine nucleotide-binding protein subunit beta-like protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an altenate splice site which results in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC133488, AK016952

Conserved Domains (2) summary

sd00039
Location:108 → 147

7WD40; WD40 repeat [structural motif]

cl29593
Location:71 → 219

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001285493.1 → NP_001272422.1 guanine nucleotide-binding protein subunit beta-like protein 1 isoform 3

See identical proteins and their annotated locations for NP_001272422.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (3) is longer than isoform 1.

Source sequence(s)

AC133488, AK158210

Consensus CDS

CCDS88896.1

UniProtKB/TrEMBL

Q3TZ04

Related

ENSMUSP00000130371.3, ENSMUST00000167778.9

Conserved Domains (2) summary

sd00039
Location:242 → 281

7WD40; WD40 repeat [structural motif]

cl29593
Location:11 → 352

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001285494.1 → NP_001272423.1 guanine nucleotide-binding protein subunit beta-like protein 1 isoform 4

See identical proteins and their annotated locations for NP_001272423.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate splice site in the 3' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AC133488

Consensus CDS

CCDS70695.1

UniProtKB/TrEMBL

Q3TBG5, Q3TM20

Related

ENSMUSP00000111264.2, ENSMUST00000115601.8

Conserved Domains (3) summary

COG2319
Location:14 → 308

WD40; WD40 repeat [General function prediction only]

sd00039
Location:24 → 64

7WD40; WD40 repeat [structural motif]

cl02567
Location:11 → 307

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_023120.5 → NP_075609.2 guanine nucleotide-binding protein subunit beta-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_075609.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1)

Source sequence(s)

AC133488

Consensus CDS

CCDS28022.1

UniProtKB/Swiss-Prot

Q8R1F3, Q9CWP2, Q9D3Y1, Q9EQ15

UniProtKB/TrEMBL

Q3TBG5

Related

ENSMUSP00000087544.5, ENSMUST00000090086.11

Conserved Domains (2) summary

sd00039
Location:23 → 64

7WD40; WD40 repeat [structural motif]

cl29593
Location:11 → 321

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

NR_104347.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC133488

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

18316029..18385430

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159780.1 → XP_036015673.1 guanine nucleotide-binding protein subunit beta-like protein 1 isoform X4

UniProtKB/TrEMBL

Q3TZ04

Conserved Domains (2) summary

sd00039
Location:242 → 281

7WD40; WD40 repeat [structural motif]

cl29593
Location:11 → 352

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011245829.4 → XP_011244131.1 guanine nucleotide-binding protein subunit beta-like protein 1 isoform X4

See identical proteins and their annotated locations for XP_011244131.1

UniProtKB/TrEMBL

Q3TZ04

Conserved Domains (2) summary

sd00039
Location:242 → 281

7WD40; WD40 repeat [structural motif]

cl29593
Location:11 → 352

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011245832.4 → XP_011244134.1 guanine nucleotide-binding protein subunit beta-like protein 1 isoform X7

See identical proteins and their annotated locations for XP_011244134.1

Conserved Domains (2) summary

sd00039
Location:68 → 107

7WD40; WD40 repeat [structural motif]

cl29593
Location:31 → 179

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_017316874.3 → XP_017172363.1 guanine nucleotide-binding protein subunit beta-like protein 1 isoform X7

Conserved Domains (2) summary

sd00039
Location:68 → 107

7WD40; WD40 repeat [structural motif]

cl29593
Location:31 → 179

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030248975.1 → XP_030104835.1 guanine nucleotide-binding protein subunit beta-like protein 1 isoform X6

Conserved Domains (2) summary

sd00039
Location:23 → 64

7WD40; WD40 repeat [structural motif]

cl29593
Location:11 → 249

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030248976.1 → XP_030104836.1 guanine nucleotide-binding protein subunit beta-like protein 1 isoform X1

Conserved Domains (2) summary

sd00039
Location:108 → 147

7WD40; WD40 repeat [structural motif]

cl29593
Location:71 → 219

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011245831.1 → XP_011244133.1 guanine nucleotide-binding protein subunit beta-like protein 1 isoform X5

See identical proteins and their annotated locations for XP_011244133.1

UniProtKB/Swiss-Prot

Q8R1F3, Q9CWP2, Q9D3Y1, Q9EQ15

UniProtKB/TrEMBL

Q3TBG5

Conserved Domains (2) summary

sd00039
Location:23 → 64

7WD40; WD40 repeat [structural motif]

cl29593
Location:11 → 321

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011245830.1 → XP_011244132.1 guanine nucleotide-binding protein subunit beta-like protein 1 isoform X4

See identical proteins and their annotated locations for XP_011244132.1

UniProtKB/TrEMBL

Q3TZ04

Conserved Domains (2) summary

sd00039
Location:242 → 281

7WD40; WD40 repeat [structural motif]

cl29593
Location:11 → 352

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011245828.2 → XP_011244130.1 guanine nucleotide-binding protein subunit beta-like protein 1 isoform X2

See identical proteins and their annotated locations for XP_011244130.1

Conserved Domains (2) summary

sd00039
Location:285 → 324

7WD40; WD40 repeat [structural motif]

cl29593
Location:248 → 396

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036159779.1 → XP_036015672.1 guanine nucleotide-binding protein subunit beta-like protein 1 isoform X1

Conserved Domains (2) summary

sd00039
Location:108 → 147

7WD40; WD40 repeat [structural motif]

cl29593
Location:71 → 219

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030248974.1 → XP_030104834.1 guanine nucleotide-binding protein subunit beta-like protein 1 isoform X3

Conserved Domains (2) summary

sd00039
Location:83 → 116

7WD40; WD40 repeat [structural motif]

cl29593
Location:66 → 147

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...