Format

Send to:

Choose Destination

ADGRG4 adhesion G protein-coupled receptor G4 [ Homo sapiens (human) ]

Gene ID: 139378, updated on 12-Oct-2019

Summary

Official Symbol
ADGRG4provided by HGNC
Official Full Name
adhesion G protein-coupled receptor G4provided by HGNC
Primary source
HGNC:HGNC:18992
See related
Ensembl:ENSG00000156920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR17; GPR112; RP1-299I16
Summary
This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010]
Expression
Biased expression in duodenum (RPKM 1.3), small intestine (RPKM 0.8) and 2 other tissues See more
Orthologs

Genomic context

See ADGRG4 in Genome Data Viewer
Location:
Xq26.3
Exon count:
28
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (136300963..136416890)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (135383122..135499047)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MAP7 domain containing 3 Neighboring gene serine/threonine kinase 24 pseudogene 1 Neighboring gene HIV-1 Tat specific factor 1 Neighboring gene bombesin receptor subtype 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781E1948

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
adhesion G-protein coupled receptor G4
Names
G protein-coupled receptor 112
probable G-protein coupled receptor 112

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021219.1 RefSeqGene

    Range
    5001..120928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_153834.4NP_722576.3  adhesion G-protein coupled receptor G4

    See identical proteins and their annotated locations for NP_722576.3

    Status: REVIEWED

    Source sequence(s)
    AL161778, AY140954, AY882585
    Consensus CDS
    CCDS35409.1
    UniProtKB/Swiss-Prot
    Q8IZF6
    Related
    ENSP00000377699.1, ENST00000394143.6
    Conserved Domains (4) summary
    pfam00002
    Location:27432982
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:26842727
    GPS; GPCR proteolysis site, GPS, motif
    pfam09786
    Location:16681909
    CytochromB561_N; Cytochrome B561, N terminal
    cl22861
    Location:28210
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    136300963..136416890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531269.2XP_011529571.1  adhesion G-protein coupled receptor G4 isoform X1

    See identical proteins and their annotated locations for XP_011529571.1

    UniProtKB/Swiss-Prot
    Q8IZF6
    Related
    ENSP00000377697.1, ENST00000394141.1
    Conserved Domains (4) summary
    pfam00002
    Location:27432982
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:26842727
    GPS; GPCR proteolysis site, GPS, motif
    pfam09786
    Location:16681909
    CytochromB561_N; Cytochrome B561, N terminal
    cl22861
    Location:28210
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  2. XM_011531271.2XP_011529573.1  adhesion G-protein coupled receptor G4 isoform X2

    Conserved Domains (4) summary
    pfam00002
    Location:26802919
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:26212664
    GPS; GPCR proteolysis site, GPS, motif
    pfam09786
    Location:16051846
    CytochromB561_N; Cytochrome B561, N terminal
    cl22861
    Location:2147
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
Support Center