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APOOL apolipoprotein O like [ Homo sapiens (human) ]

Gene ID: 139322, updated on 1-Jun-2020

Summary

Official Symbol
APOOLprovided by HGNC
Official Full Name
apolipoprotein O likeprovided by HGNC
Primary source
HGNC:HGNC:24009
See related
Ensembl:ENSG00000155008 MIM:300955
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Mic27; CXorf33; FAM121A; MICOS27; UNQ8193
Summary
This gene encodes a protein which contains an apolipoprotein O superfamily domain. This domain is found on proteins in circulating lipoprotein complexes. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in brain (RPKM 7.7), thyroid (RPKM 6.2) and 25 other tissues See more
Orthologs

Genomic context

See APOOL in Genome Data Viewer
Location:
Xq21.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (85003852..85093315)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (84258897..84348323)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene testis expressed 16, pseudogene Neighboring gene SET pseudogene 4 Neighboring gene ubiquitin conjugating enzyme E2 D N-terminal like (pseudogene) Neighboring gene spermidine/spermine N1-acetyl transferase like 1 Neighboring gene uncharacterized LOC101928128 Neighboring gene zinc finger protein 711

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129748

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cristae formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inner mitochondrial membrane organization IC
Inferred by Curator
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
MICOS complex HDA PubMed 
MICOS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MICOS complex IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
mitochondrial sorting and assembly machinery complex HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
MICOS complex subunit MIC27
Names
AAIR8193
family with sequence similarity 121A
mitochondrial contact site and cristae organizing system subunit 27

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021245.2 RefSeqGene

    Range
    4979..94417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_198450.6NP_940852.3  MICOS complex subunit MIC27 precursor

    See identical proteins and their annotated locations for NP_940852.3

    Status: REVIEWED

    Source sequence(s)
    AK130506, BE328646, Z83820, Z99571
    Consensus CDS
    CCDS48138.1
    UniProtKB/Swiss-Prot
    Q6UXV4
    Related
    ENSP00000362268.2, ENST00000373173.7
    Conserved Domains (1) summary
    pfam09769
    Location:42179
    ApoO; Apolipoprotein O

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    85003852..85093315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029272.1XP_016884761.1  MICOS complex subunit MIC27 isoform X3

  2. XM_017029271.1XP_016884760.1  MICOS complex subunit MIC27 isoform X1

  3. XM_011530859.2XP_011529161.1  MICOS complex subunit MIC27 isoform X2

    Conserved Domains (1) summary
    pfam09769
    Location:47184
    ApoO; Apolipoprotein O
  4. XM_017029273.1XP_016884762.1  MICOS complex subunit MIC27 isoform X4

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