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APOOL apolipoprotein O like [ Homo sapiens (human) ]

Gene ID: 139322, updated on 19-Sep-2024

Summary

Official Symbol
APOOLprovided by HGNC
Official Full Name
apolipoprotein O likeprovided by HGNC
Primary source
HGNC:HGNC:24009
See related
Ensembl:ENSG00000155008 MIM:300955; AllianceGenome:HGNC:24009
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Mic27; CXorf33; FAM121A; MICOS27; UNQ8193
Summary
This gene encodes a protein which contains an apolipoprotein O superfamily domain. This domain is found on proteins in circulating lipoprotein complexes. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in brain (RPKM 7.7), thyroid (RPKM 6.2) and 25 other tissues See more
Orthologs
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Genomic context

See APOOL in Genome Data Viewer
Location:
Xq21.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (85003877..85093315)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (83432345..83522274)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (84258883..84348321)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene testis expressed 16, pseudogene Neighboring gene SET pseudogene 4 Neighboring gene ubiquitin conjugating enzyme E2 D N-terminal like (pseudogene) Neighboring gene spermidine/spermine N1-acetyl transferase like 1 Neighboring gene uncharacterized LOC101928128 Neighboring gene zinc finger protein 711

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC129748

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cristae formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cristae formation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in inner mitochondrial membrane organization IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
MICOS complex subunit MIC27
Names
AAIR8193
family with sequence similarity 121A
mitochondrial contact site and cristae organizing system subunit 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021245.2 RefSeqGene

    Range
    4979..94417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_198450.6NP_940852.3  MICOS complex subunit MIC27 precursor

    Status: REVIEWED

    Source sequence(s)
    AK130506, BE328646, Z83820, Z99571
    Consensus CDS
    CCDS48138.1
    UniProtKB/Swiss-Prot
    Q3KNU7, Q5H9D1, Q6UXV4
    Related
    ENSP00000362268.2, ENST00000373173.7
    Conserved Domains (1) summary
    pfam09769
    Location:55179
    ApoO; Apolipoprotein O

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    85003877..85093315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029272.2XP_016884761.1  MICOS complex subunit MIC27 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    83432345..83522274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326470.1XP_054182445.1  MICOS complex subunit MIC27 isoform X2

  2. XM_054326469.1XP_054182444.1  MICOS complex subunit MIC27 isoform X1

  3. XM_054326471.1XP_054182446.1  MICOS complex subunit MIC27 isoform X3