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PASD1 PAS domain containing repressor 1 [ Homo sapiens (human) ]

Gene ID: 139135, updated on 11-Jun-2021

Summary

Official Symbol
PASD1provided by HGNC
Official Full Name
PAS domain containing repressor 1provided by HGNC
Primary source
HGNC:HGNC:20686
See related
Ensembl:ENSG00000166049 MIM:300993
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT63; CT64; OXTES1
Summary
This gene encodes a protein that is thought to function as a transcription factor. The protein is a cancer-associated antigen that can stimulate autologous T-cell responses, and it is therefore considered to be a potential immunotherapeutic target for the treatment of various hematopoietic malignancies, including diffuse large B-cell lymphoma. [provided by RefSeq, May 2010]
Expression
Restricted expression toward testis (RPKM 11.6) See more
Orthologs
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Genomic context

See PASD1 in Genome Data Viewer
Location:
Xq28
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (151563184..151676739)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (150732147..150845211)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985693 Neighboring gene vacuolar ATPase assembly factor VMA21 Neighboring gene uncharacterized LOC105373367 Neighboring gene uncharacterized LOC105377213 Neighboring gene proline rich and Gla domain 3 Neighboring gene fetal and adult testis expressed 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of CLOCK-BMAL transcription complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Cry-Per complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
circadian clock protein PASD1
Names
PAS domain containing 1
cancer/testis antigen 63

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021218.1 RefSeqGene

    Range
    5141..118205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_173493.3NP_775764.2  circadian clock protein PASD1

    See identical proteins and their annotated locations for NP_775764.2

    Status: REVIEWED

    Source sequence(s)
    AF274854, AK097552, BC040301, DB523527
    Consensus CDS
    CCDS35431.1
    UniProtKB/Swiss-Prot
    Q8IV76
    Related
    ENSP00000359382.4, ENST00000370357.5
    Conserved Domains (1) summary
    cd00130
    Location:41137
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    151563184..151676739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531102.2XP_011529404.1  circadian clock protein PASD1 isoform X1

    Conserved Domains (2) summary
    cd00130
    Location:41137
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:32137
    PAS; PAS fold
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