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Ercc3 excision repair cross-complementing rodent repair deficiency, complementation group 3 [ Mus musculus (house mouse) ]

Gene ID: 13872, updated on 8-Feb-2024

Summary

Official Symbol
Ercc3provided by MGI
Official Full Name
excision repair cross-complementing rodent repair deficiency, complementation group 3provided by MGI
Primary source
MGI:MGI:95414
See related
Ensembl:ENSMUSG00000024382 AllianceGenome:MGI:95414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
XPB; Ercc-3; BTF2 p89
Summary
Enables ATP hydrolysis activity and promoter-specific chromatin binding activity. Acts upstream of or within UV protection and transcription elongation from RNA polymerase I promoter. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex; nucleotide-excision repair factor 3 complex; and transcription preinitiation complex. Is expressed in several structures, including brain; eye; liver; oral region epithelium; and tooth. Used to study xeroderma pigmentosum group B. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; photosensitive trichothiodystrophy 2; trichothiodystrophy; xeroderma pigmentosum; and xeroderma pigmentosum group B. Orthologous to human ERCC3 (ERCC excision repair 3, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 17.5), bladder adult (RPKM 13.4) and 28 other tissues See more
Orthologs
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Genomic context

See Ercc3 in Genome Data Viewer
Location:
18 B1; 18 17.97 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (32373357..32403206)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (32240304..32270151)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11799 Neighboring gene predicted gene, 26717 Neighboring gene predicted gene, 34806 Neighboring gene mitogen-activated protein kinase kinase kinase 2 Neighboring gene STARR-seq mESC enhancer starr_44156 Neighboring gene STARR-positive B cell enhancer ABC_E5649 Neighboring gene STARR-seq mESC enhancer starr_44157 Neighboring gene RIKEN cDNA A830052D11 gene Neighboring gene bridging integrator 1 Neighboring gene testis expressed 51

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 3'-5' DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA topological change ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within UV protection IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic organ development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hair cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hair cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleotide-excision repair, DNA duplex unwinding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within transcription elongation by RNA polymerase I EXP
Inferred from Experiment
more info
PubMed 
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transcription initiation at RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription-coupled nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of nucleotide-excision repair factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFIIH core complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription factor TFIIH holo complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
general transcription and DNA repair factor IIH helicase subunit XPB
Names
DNA excision repair protein ERCC-3
DNA repair protein complementing XP-B cells
TFIIH 89 kDa subunit
TFIIH basal transcription factor complex helicase XPB subunit
basic transcription factor 2 89 kDa subunit
xeroderma pigmentosum group B-complementing protein
NP_598419.1
XP_006525699.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133658.2NP_598419.1  general transcription and DNA repair factor IIH helicase subunit XPB

    See identical proteins and their annotated locations for NP_598419.1

    Status: VALIDATED

    Source sequence(s)
    BC022956, BY273530, S71186
    Consensus CDS
    CCDS29118.1
    UniProtKB/Swiss-Prot
    P49135
    UniProtKB/TrEMBL
    Q3U3I5
    Related
    ENSMUSP00000025241.7, ENSMUST00000025241.7
    Conserved Domains (4) summary
    TIGR00603
    Location:60780
    rad25; DNA repair helicase rad25
    pfam04851
    Location:316473
    ResIII; Type III restriction enzyme, res subunit
    pfam13625
    Location:76198
    Helicase_C_3; Helicase conserved C-terminal domain
    pfam16203
    Location:497740
    ERCC3_RAD25_C; ERCC3/RAD25/XPB C-terminal helicase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    32373357..32403206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525636.2XP_006525699.1  general transcription and DNA repair factor IIH helicase subunit XPB isoform X1

    Conserved Domains (1) summary
    TIGR00603
    Location:60578
    rad25; DNA repair helicase rad25

RNA

  1. XR_385973.2 RNA Sequence