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Erbb4 erb-b2 receptor tyrosine kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 13869, updated on 21-Dec-2019

Summary

Official Symbol
Erbb4provided by MGI
Official Full Name
erb-b2 receptor tyrosine kinase 4provided by MGI
Primary source
MGI:MGI:104771
See related
Ensembl:ENSMUSG00000062209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Her4; c-erbB-4
Expression
Biased expression in CNS E18 (RPKM 2.3), frontal lobe adult (RPKM 2.1) and 8 other tissues See more
Orthologs

Genomic context

See Erbb4 in Genome Data Viewer
Location:
1 C3; 1 33.8 cM
Exon count:
30
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (68031884..69108576, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (68086540..69154633, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene kinesin family member 22, pseudogene Neighboring gene VISTA enhancer mm148 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene predicted gene, 51744 Neighboring gene predicted gene 8840 Neighboring gene PC-esterase domain containing 1C, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
neuregulin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle tissue regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cellular response to epidermal growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
central nervous system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
lactation ISO
Inferred from Sequence Orthology
more info
 
mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial fragmentation involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
olfactory bulb interneuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JAK-STAT cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
NOT positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein localization to cell surface IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
surfactant homeostasis ISO
Inferred from Sequence Orthology
more info
 
synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
synapse maturation ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
basal plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
caveola ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
receptor tyrosine-protein kinase erbB-4
Names
avian erythroblastosis oncogene B 4
proto-oncogene-like protein c-ErbB-4
v-erb-a erythroblastic leukemia viral oncogene homolog 4
NP_034284.1
XP_006495755.1
XP_006495756.1
XP_006495757.1
XP_006495758.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010154.2NP_034284.1  receptor tyrosine-protein kinase erbB-4 precursor

    See identical proteins and their annotated locations for NP_034284.1

    Status: VALIDATED

    Source sequence(s)
    AC167658, AK144050
    Consensus CDS
    CCDS48285.1
    UniProtKB/Swiss-Prot
    Q61527
    Related
    ENSMUSP00000114123.1, ENSMUST00000121473.7
    Conserved Domains (8) summary
    cd05110
    Location:7101012
    PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
    cd12092
    Location:642685
    TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
    smart00261
    Location:549596
    FU; Furin-like repeats
    cd00064
    Location:229274
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:186332
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:55167
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:718974
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:502634
    GF_recep_IV; Growth factor receptor domain IV

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p6 C57BL/6J

    Range
    68031884..69108576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495692.4XP_006495755.1  receptor tyrosine-protein kinase erbB-4 isoform X1

    See identical proteins and their annotated locations for XP_006495755.1

    UniProtKB/Swiss-Prot
    Q61527
    Related
    ENSMUSP00000112713.1, ENSMUST00000119142.7
    Conserved Domains (8) summary
    cd05110
    Location:7101012
    PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
    cd12092
    Location:642685
    TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
    smart00261
    Location:549596
    FU; Furin-like repeats
    cd00064
    Location:229274
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:186332
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:55167
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:718974
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:502634
    GF_recep_IV; Growth factor receptor domain IV
  2. XM_006495693.4XP_006495756.1  receptor tyrosine-protein kinase erbB-4 isoform X2

    See identical proteins and their annotated locations for XP_006495756.1

    UniProtKB/Swiss-Prot
    Q61527
    Conserved Domains (8) summary
    cd05110
    Location:7001002
    PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
    cd12092
    Location:632675
    TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
    smart00261
    Location:549596
    FU; Furin-like repeats
    cd00064
    Location:229274
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:186332
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:55167
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:708964
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:502634
    GF_recep_IV; Growth factor receptor domain IV
  3. XM_006495694.4XP_006495757.1  receptor tyrosine-protein kinase erbB-4 isoform X3

    Conserved Domains (8) summary
    cd05110
    Location:7001002
    PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
    cd12092
    Location:632675
    TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
    smart00261
    Location:549596
    FU; Furin-like repeats
    cd00064
    Location:229274
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:186332
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:55167
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:708964
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:502634
    GF_recep_IV; Growth factor receptor domain IV
  4. XM_006495695.4XP_006495758.1  receptor tyrosine-protein kinase erbB-4 isoform X4

    Related
    ENSMUSP00000115373.1, ENSMUST00000153432.1
    Conserved Domains (7) summary
    cd12092
    Location:642685
    TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
    smart00261
    Location:549596
    FU; Furin-like repeats
    cd00064
    Location:229274
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:186332
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:55167
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:502634
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:710829
    PKc_like; Protein Kinases, catalytic domain

Reference GRCm38.p6 NOD/MrkTac

Genomic

  1. NT_187020.1 Reference GRCm38.p6 NOD/MrkTac

    Range
    2569951..3623392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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