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Erbb3 erb-b2 receptor tyrosine kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 13867, updated on 29-Jun-2021

Summary

Official Symbol
Erbb3provided by MGI
Official Full Name
erb-b2 receptor tyrosine kinase 3provided by MGI
Primary source
MGI:MGI:95411
See related
Ensembl:ENSMUSG00000018166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HER; Erbb; Her3; Erbb-; C76256; Erbb-3; Erbb3r
Expression
Biased expression in colon adult (RPKM 49.8), large intestine adult (RPKM 38.8) and 13 other tissues See more
Orthologs
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Genomic context

See Erbb3 in Genome Data Viewer
Location:
10 D3; 10 77.1 cM
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128403392..128425504, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128567523..128589635, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (128006424..128026557, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9176 Neighboring gene proliferation-associated 2G4 Neighboring gene microRNA 6917 Neighboring gene predicted gene 9182 Neighboring gene ribosomal protein S26

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117742

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ErbB-3 class receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables neuregulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neuregulin binding ISO
Inferred from Sequence Orthology
more info
 
enables neuregulin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neuregulin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
NOT enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Schwann cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cranial nerve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endocardial cushion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of calcineurin-NFAT signaling cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within transmembrane receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of ERBB3:ERBB2 complex ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in basal plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
receptor tyrosine-protein kinase erbB-3
Names
avian erythroblastosis oncogene B 3 receptor
c-erbB-3
glial growth factor receptor
proto-oncogene-like protein c-ErbB-3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
NP_034283.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010153.2NP_034283.1  receptor tyrosine-protein kinase erbB-3 precursor

    See identical proteins and their annotated locations for NP_034283.1

    Status: VALIDATED

    Source sequence(s)
    AA119766, AC117232, BC106091
    Consensus CDS
    CCDS24283.1
    UniProtKB/Swiss-Prot
    Q61526
    Related
    ENSMUSP00000080716.7, ENSMUST00000082059.7
    Conserved Domains (8) summary
    cd12095
    Location:638674
    TM_ErbB3; Transmembrane domain of ErbB3, a Protein Tyrosine Kinase
    smart00261
    Location:548592
    FU; Furin-like repeats
    cd00064
    Location:226266
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:179329
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:353474
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:707963
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:499630
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:699977
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128403392..128425504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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