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Eps15l1 epidermal growth factor receptor pathway substrate 15-like 1 [ Mus musculus (house mouse) ]

Gene ID: 13859, updated on 2-Nov-2024

Summary

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Official Symbol
Eps15l1provided by MGI
Official Full Name
epidermal growth factor receptor pathway substrate 15-like 1provided by MGI
Primary source
MGI:MGI:104582
See related
Ensembl:ENSMUSG00000006276 AllianceGenome:MGI:104582
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eps15R; Eps15-rs; 9830147J04Rik
Summary
Predicted to enable calcium ion binding activity. Involved in synaptic vesicle endocytosis. Part of clathrin coat of coated pit. Is active in presynapse. Is expressed in several structures, including alimentary system; liver; metanephros; nervous system; and sensory organ. Orthologous to human EPS15L1 (epidermal growth factor receptor pathway substrate 15 like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 13.8), CNS E14 (RPKM 12.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Eps15l1 in Genome Data Viewer
Location:
8 B3.3; 8 35.02 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (73094834..73175410, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72340990..72421576, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21852 Neighboring gene high mobility group nucleosomal binding domain 2, pseudogene Neighboring gene STARR-seq mESC enhancer starr_21853 Neighboring gene STARR-positive B cell enhancer ABC_E3785 Neighboring gene STARR-seq mESC enhancer starr_21854 Neighboring gene STARR-seq mESC enhancer starr_21858 Neighboring gene Kruppel-like transcription factor 2 (lung) Neighboring gene STARR-positive B cell enhancer ABC_E8247 Neighboring gene STARR-positive B cell enhancer ABC_E9731 Neighboring gene STARR-positive B cell enhancer ABC_E5020 Neighboring gene predicted gene, 46043 Neighboring gene calreticulin 3 Neighboring gene RIKEN cDNA 1700030K09 gene Neighboring gene STARR-positive B cell enhancer ABC_E359 Neighboring gene calcium homeostasis endoplasmic reticulum protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Eps15R and clathrin regulate EphB2-mediated cell repulsion. Evergren E, et al. Traffic, 2018 Jan. PMID 28972287, Free PMC Article
  2. Differential patterns of expression of Eps15 and Eps15R during mouse embryogenesis. Offenhäuser N, et al. Mech Dev, 2000 Jul. PMID 10906484
  3. Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization. Coda L, et al. J Biol Chem, 1998 Jan 30. PMID 9446614
  4. A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins. Polo S, et al. Nature, 2002 Mar 28. PMID 11919637
  5. A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution. Wong WT, et al. Proc Natl Acad Sci U S A, 1995 Oct 10. PMID 7568168, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel interaction motif in Eps15R, DPFxxLDPF, is shown to bind directly to the clathrin terminal domain in vitro. Interaction between Eps15R and clathrin is required for EphB2-mediated cell repulsion.
    Title: Eps15R and clathrin regulate EphB2-mediated cell repulsion.
  2. EPS15 and EPS15R mediated internalization of activated EGF receptor to result in receptor recycling as to reinforce the proliferative response to EGF.
    Title: EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.
  3. a short amino-acid stretch at the carboxy-termini of the monoubiquitinated endocytic proteins Eps15 and eps15R is indispensable for their monoubiquitination
    Title: A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle endocytosis IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of clathrin coat of coated pit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of clathrin coat of coated pit IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in presynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
epidermal growth factor receptor substrate 15-like 1
Names
epidermal growth factor receptor pathway substrate 15-related sequence
eps15-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122832.1 → NP_001116304.1  epidermal growth factor receptor substrate 15-like 1 isoform b

    See identical proteins and their annotated locations for NP_001116304.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several 3' exons compared to variant 1, and its 3' terminal exon extends past a splice site that is used in variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA217470, AK036728, BY270130
    Consensus CDS
    CCDS85560.1
    UniProtKB/TrEMBL
    A0A1D5RLS1
    Related
    ENSMUSP00000148484.2, ENSMUST00000212590.3
    Conserved Domains (4) summary
    smart00027
    Location:266 → 362
    EH; Eps15 homology domain
    cd00052
    Location:131 → 196
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam07926
    Location:396 → 523
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    cl23720
    Location:400 → 517
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  2. NM_001289859.1 → NP_001276788.1  epidermal growth factor receptor substrate 15-like 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks two consecutive exons in the 3' coding region, compared to variant 1. It encodes isoform c, which is shorter than isoform a.
    Source sequence(s)
    AK146781, AK152602, BB855263, CD774936
    Consensus CDS
    CCDS85561.1
    UniProtKB/Swiss-Prot
    Q60902
    Related
    ENSMUSP00000148468.2, ENSMUST00000212121.2
    Conserved Domains (4) summary
    smart00027
    Location:266 → 362
    EH; Eps15 homology domain
    cd00052
    Location:131 → 196
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam07926
    Location:396 → 523
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    cl23720
    Location:400 → 517
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  3. NM_007944.3 → NP_031970.2  epidermal growth factor receptor substrate 15-like 1 isoform a

    See identical proteins and their annotated locations for NP_031970.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK146781, BY270130, CD774936
    Consensus CDS
    CCDS52597.1
    UniProtKB/Swiss-Prot
    Q3U7L9, Q3UIS9, Q60902, Q8CB60, Q8CB70, Q91WH8
    Related
    ENSMUSP00000129739.2, ENSMUST00000163643.3
    Conserved Domains (4) summary
    smart00027
    Location:266 → 362
    EH; Eps15 homology domain
    cd00052
    Location:131 → 196
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam07926
    Location:396 → 523
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    cl02488
    Location:383 → 564
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    73094834..73175410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312560.3 → XP_017168049.1  epidermal growth factor receptor substrate 15-like 1 isoform X6

    Conserved Domains (3) summary
    smart00027
    Location:266 → 362
    EH; Eps15 homology domain
    COG1196
    Location:383 → 565
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl27812
    Location:13 → 103
    EF-hand_4; Cytoskeletal-regulatory complex EF hand

  2. XM_006509550.4 → XP_006509613.1  epidermal growth factor receptor substrate 15-like 1 isoform X7

    Conserved Domains (2) summary
    COG1196
    Location:97 → 278
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl27812
    Location:30 → 76
    EF-hand_4; Cytoskeletal-regulatory complex EF hand

  3. XM_006509548.5 → XP_006509611.1  epidermal growth factor receptor substrate 15-like 1 isoform X5

    Conserved Domains (3) summary
    smart00027
    Location:266 → 362
    EH; Eps15 homology domain
    COG1196
    Location:383 → 564
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl27812
    Location:13 → 103
    EF-hand_4; Cytoskeletal-regulatory complex EF hand

  4. XM_006509547.5 → XP_006509610.1  epidermal growth factor receptor substrate 15-like 1 isoform X4

    Conserved Domains (3) summary
    smart00027
    Location:266 → 362
    EH; Eps15 homology domain
    COG1196
    Location:383 → 564
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl27812
    Location:13 → 103
    EF-hand_4; Cytoskeletal-regulatory complex EF hand

  5. XM_006509544.5 → XP_006509607.1  epidermal growth factor receptor substrate 15-like 1 isoform X1

    UniProtKB/TrEMBL
    A0AAQ4VMU6
    Related
    ENSMUSP00000159997.1, ENSMUST00000249899.1
    Conserved Domains (3) summary
    smart00027
    Location:266 → 362
    EH; Eps15 homology domain
    COG1196
    Location:383 → 564
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl27812
    Location:13 → 103
    EF-hand_4; Cytoskeletal-regulatory complex EF hand

  6. XM_006509546.5 → XP_006509609.1  epidermal growth factor receptor substrate 15-like 1 isoform X3

    Conserved Domains (3) summary
    smart00027
    Location:266 → 362
    EH; Eps15 homology domain
    COG1196
    Location:383 → 565
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl27812
    Location:13 → 103
    EF-hand_4; Cytoskeletal-regulatory complex EF hand

  7. XM_006509545.5 → XP_006509608.1  epidermal growth factor receptor substrate 15-like 1 isoform X2

    Conserved Domains (3) summary
    smart00027
    Location:266 → 362
    EH; Eps15 homology domain
    COG1196
    Location:383 → 565
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl27812
    Location:13 → 103
    EF-hand_4; Cytoskeletal-regulatory complex EF hand

RNA

  1. XR_004934761.1 RNA Sequence

  2. XR_379029.5 RNA Sequence

  3. XR_379032.5 RNA Sequence

  4. XR_001778398.3 RNA Sequence

  5. XR_003947228.2 RNA Sequence

  6. XR_379030.5 RNA Sequence

  7. XR_004934766.1 RNA Sequence

  8. XR_004934765.1 RNA Sequence

  9. XR_004934767.1 RNA Sequence

  10. XR_004934763.1 RNA Sequence

  11. XR_001778400.3 RNA Sequence

  12. XR_004934764.1 RNA Sequence

  13. XR_003947230.2 RNA Sequence

  14. XR_379031.5 RNA Sequence

    Related
    ENSMUST00000212950.2

  15. XR_004934762.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60902.3 GenPept UniProtKB/Swiss-Prot:Q60902

Gene LinkOut

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