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Eps15 epidermal growth factor receptor pathway substrate 15 [ Mus musculus (house mouse) ]

Gene ID: 13858, updated on 5-Mar-2024

Summary

Official Symbol
Eps15provided by MGI
Official Full Name
epidermal growth factor receptor pathway substrate 15provided by MGI
Primary source
MGI:MGI:104583
See related
Ensembl:ENSMUSG00000028552 AllianceGenome:MGI:104583
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410112D09Rik
Summary
Enables identical protein binding activity. Acts upstream of or within regulation of protein localization. Located in ciliary membrane; clathrin-coated pit; and clathrin-coated vesicle. Part of AP-2 adaptor complex. Is expressed in several structures, including adrenal gland; alimentary system; heart; metanephros; and nervous system. Orthologous to human EPS15 (epidermal growth factor receptor pathway substrate 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 26.3), cerebellum adult (RPKM 24.7) and 21 other tissues See more
Orthologs
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Genomic context

See Eps15 in Genome Data Viewer
Location:
4 C7; 4 51.29 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (109137372..109245014)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (109280175..109387817)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 9 Neighboring gene STARR-positive B cell enhancer ABC_E11807 Neighboring gene predicted gene, 46867 Neighboring gene predicted gene, 40225 Neighboring gene calreticulin 4 Neighboring gene STARR-positive B cell enhancer ABC_E2703 Neighboring gene predicted gene, 52753 Neighboring gene predicted gene, 52702 Neighboring gene basic leucine zipper and W2 domains 1 pseudogene Neighboring gene Ttc39a opposite strand RNA 1 Neighboring gene tetratricopeptide repeat domain 39A Neighboring gene STARR-seq mESC enhancer starr_11070 Neighboring gene ring finger protein 11

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in Golgi to endosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor-mediated endocytosis of virus by host cell ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in symbiont entry into host cell ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of AP-2 adaptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in aggresome ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of clathrin coat of coated pit IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of clathrin coat of coated pit IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
epidermal growth factor receptor substrate 15
Names
epidermal growth factor pathway substrate 15
protein AF-1p

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159964.1NP_001153436.1  epidermal growth factor receptor substrate 15 isoform B

    See identical proteins and their annotated locations for NP_001153436.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple exons at the 5' end and has a distinct 5' UTR and start codon, compared to variant 1. These differences result in a protein (isoform B) with a shorter and distinct N-terminus, compared to isoform A. Isoform B localizes to early endosome membranes.
    Source sequence(s)
    AK083176, AW124983, BC048783, CF533628
    Consensus CDS
    CCDS51259.1
    UniProtKB/TrEMBL
    A0A0R4J0A0
    Related
    ENSMUSP00000030281.6, ENSMUST00000030281.12
    Conserved Domains (2) summary
    pfam07926
    Location:89192
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    cl19219
    Location:86159
    DUF342; Protein of unknown function (DUF342)
  2. NM_007943.3NP_031969.1  epidermal growth factor receptor substrate 15 isoform A

    See identical proteins and their annotated locations for NP_031969.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A). Isoform A mainly localizes to clathrin-coated pits at the plasma membrane.
    Source sequence(s)
    AK083176, AW124983, BB858255, BC048783
    Consensus CDS
    CCDS18462.1
    UniProtKB/Swiss-Prot
    P42567, Q8C431
    UniProtKB/TrEMBL
    Q5JC28, Q80ZL3
    Related
    ENSMUSP00000099790.4, ENSMUST00000102729.10
    Conserved Domains (5) summary
    smart00027
    Location:121215
    EH; Eps15 homology domain
    cd00052
    Location:228293
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam07926
    Location:403506
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam12761
    Location:321458
    End3; Actin cytoskeleton-regulatory complex protein END3
    cl23720
    Location:396497
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    109137372..109245014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319956.2XP_017175445.1  epidermal growth factor receptor substrate 15 isoform X5

    UniProtKB/TrEMBL
    Q5JC28
    Related
    ENSMUSP00000135034.2, ENSMUST00000176251.8
    Conserved Domains (2) summary
    smart00027
    Location:121215
    EH; Eps15 homology domain
    TIGR02168
    Location:333509
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  2. XM_006502738.3XP_006502801.2  epidermal growth factor receptor substrate 15 isoform X1

    UniProtKB/TrEMBL
    H3BK65, Q5JC28
    Related
    ENSMUSP00000135270.2, ENSMUST00000175776.8
    Conserved Domains (2) summary
    smart00027
    Location:121215
    EH; Eps15 homology domain
    TIGR02168
    Location:369545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  3. XM_006502740.3XP_006502803.2  epidermal growth factor receptor substrate 15 isoform X4

    UniProtKB/TrEMBL
    Q5JC28
    Conserved Domains (2) summary
    smart00027
    Location:121215
    EH; Eps15 homology domain
    TIGR02168
    Location:369545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  4. XM_006502739.5XP_006502802.2  epidermal growth factor receptor substrate 15 isoform X2

    UniProtKB/TrEMBL
    Q5JC28
    Conserved Domains (3) summary
    smart00027
    Location:89183
    EH; Eps15 homology domain
    cd00052
    Location:1971
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    TIGR02168
    Location:337513
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  5. XM_030253192.2XP_030109052.1  epidermal growth factor receptor substrate 15 isoform X3

    UniProtKB/TrEMBL
    Q5JC28
    Conserved Domains (3) summary
    smart00027
    Location:89183
    EH; Eps15 homology domain
    cd00052
    Location:1971
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    TIGR02168
    Location:301477
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type