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Ephx2 epoxide hydrolase 2, cytoplasmic [ Mus musculus (house mouse) ]

Gene ID: 13850, updated on 3-Nov-2024

Summary

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Official Symbol
Ephx2provided by MGI
Official Full Name
epoxide hydrolase 2, cytoplasmicprovided by MGI
Primary source
MGI:MGI:99500
See related
Ensembl:ENSMUSG00000022040 AllianceGenome:MGI:99500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CEH; SEH; sEP; Eph2
Summary
Enables epoxide hydrolase activity. Involved in several processes, including cholesterol homeostasis; epoxide metabolic process; and regulation of cholesterol metabolic process. Predicted to be located in cytosol. Predicted to be active in peroxisome. Is expressed in several structures, including eye; heart; integumental system; nervous system; and urinary system. Human ortholog(s) of this gene implicated in coronary artery disease; familial hypercholesterolemia; and hypertension. Orthologous to human EPHX2 (epoxide hydrolase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 79.4), ovary adult (RPKM 75.1) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Ephx2 in Genome Data Viewer
Location:
14 D1; 14 34.36 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (66321821..66361971, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (66084372..66124522, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene gulonolactone (L-) oxidase Neighboring gene STARR-seq mESC enhancer starr_36985 Neighboring gene a disintegrin and metallopeptidase domain 2 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_36988 Neighboring gene STARR-positive B cell enhancer ABC_E5450 Neighboring gene cholinergic receptor nicotinic alpha 2 subunit Neighboring gene PTK2 protein tyrosine kinase 2 beta Neighboring gene STARR-positive B cell enhancer ABC_E7326 Neighboring gene predicted gene, 52098

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication. Vito ST, et al. Toxicol Appl Pharmacol, 2014 Dec 1. PMID 25448683, Free PMC Article
  2. Proteomic analysis of hearts from Akita mice suggests that increases in soluble epoxide hydrolase and antioxidative programming are key changes in early stages of diabetic cardiomyopathy. Dewey S, et al. J Proteome Res, 2013 Sep 6. PMID 23848590
  3. Epoxyeicosanoids promote organ and tissue regeneration. Panigrahy D, et al. Proc Natl Acad Sci U S A, 2013 Aug 13. PMID 23898174, Free PMC Article
  4. Role of soluble epoxide hydrolase in exacerbation of stroke by streptozotocin-induced type 1 diabetes mellitus. Jouihan SA, et al. J Cereb Blood Flow Metab, 2013 Oct. PMID 23899929, Free PMC Article
  5. Soluble epoxide hydrolase deficiency inhibits dextran sulfate sodium-induced colitis and carcinogenesis in mice. Zhang W, et al. Anticancer Res, 2013 Dec. PMID 24324059, Free PMC Article

See all (189) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of the soluble epoxide hydrolase in keratinocyte proliferation and sensitivity of skin to inflammatory stimuli.
    Title: Role of the soluble epoxide hydrolase in keratinocyte proliferation and sensitivity of skin to inflammatory stimuli.
  2. Soluble Epoxide Hydrolase Contributes to Cell Senescence and ER Stress in Aging Mice Colon.
    Title: Soluble Epoxide Hydrolase Contributes to Cell Senescence and ER Stress in Aging Mice Colon.
  3. Hepatic soluble epoxide hydrolase activity regulates cerebral Abeta metabolism and the pathogenesis of Alzheimer's disease in mice.
    Title: Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer's disease in mice.
  4. Soluble epoxide hydrolase deficiency promotes liver regeneration and ameliorates liver injury in mice by regulating angiocrine factors and angiogenesis.
    Title: Soluble epoxide hydrolase deficiency promotes liver regeneration and ameliorates liver injury in mice by regulating angiocrine factors and angiogenesis.
  5. Targeting soluble epoxide hydrolase promotes osteogenic-angiogenic coupling via activating SLIT3/HIF-1alpha signalling pathway.
    Title: Targeting soluble epoxide hydrolase promotes osteogenic-angiogenic coupling via activating SLIT3/HIF-1α signalling pathway.
  6. Decreased Expression of Soluble Epoxide Hydrolase Suppresses Murine Choroidal Neovascularization.
    Title: Decreased Expression of Soluble Epoxide Hydrolase Suppresses Murine Choroidal Neovascularization.
  7. Role of the soluble epoxide hydrolase in the hair follicle stem cell homeostasis and hair growth.
    Title: Role of the soluble epoxide hydrolase in the hair follicle stem cell homeostasis and hair growth.
  8. Preservation of epoxyeicosatrienoic acid bioavailability prevents renal allograft dysfunction and cardiovascular alterations in kidney transplant recipients.
    Title: Preservation of epoxyeicosatrienoic acid bioavailability prevents renal allograft dysfunction and cardiovascular alterations in kidney transplant recipients.
  9. Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease.
    Title: Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease.
  10. sEH promotes macrophage phagocytosis and lung clearance of Streptococcus pneumoniae.
    Title: sEH promotes macrophage phagocytosis and lung clearance of Streptococcus pneumoniae.
Submit: New GeneRIF Correction See all GeneRIFs (88)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables epoxide hydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables epoxide hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables lipid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables lipid phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lysophosphatidic acid phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables lysophosphatidic acid phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables toxic substance binding IEA
Inferred from Electronic Annotation
more info
  
enables toxic substance binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cholesterol homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in epoxide metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epoxide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in linoleic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in prostaglandin production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
  
involved_in stilbene catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in stilbene catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bifunctional epoxide hydrolase 2
Names
cytosolic epoxide hydrolase
epoxide hydratase
epoxide hydrolase 2C
soluble epoxide hydrolase
NP_001258331.1
NP_001258332.1
NP_001258350.1
NP_031966.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271402.1 → NP_001258331.1  bifunctional epoxide hydrolase 2 isoform b

    See identical proteins and their annotated locations for NP_001258331.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at the 5' exon, differs in the 5' UTR, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC126272, AK002415
    UniProtKB/TrEMBL
    Q3UQ71
    Conserved Domains (4) summary
    cd01427
    Location:58 → 150
    HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
    TIGR01509
    Location:1 → 150
    HAD-SF-IA-v3; haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED
    pfam00561
    Location:204 → 477
    Abhydrolase_1; alpha/beta hydrolase fold
    cl21494
    Location:186 → 326
    Abhydrolase; alpha/beta hydrolases

  2. NM_001271403.1 → NP_001258332.1  bifunctional epoxide hydrolase 2 isoform c

    See identical proteins and their annotated locations for NP_001258332.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant is considered to be 5' complete based on evidence from PMID: 15601917. The encoded isoform (c) contains a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC126272, AY098585
    Consensus CDS
    CCDS88694.1
    UniProtKB/TrEMBL
    Q3UQ71
    Related
    ENSMUSP00000153161.2, ENSMUST00000224698.2
    Conserved Domains (4) summary
    cd01427
    Location:93 → 185
    HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
    TIGR01509
    Location:49 → 185
    HAD-SF-IA-v3; haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED
    pfam00561
    Location:239 → 512
    Abhydrolase_1; alpha/beta hydrolase fold
    cl21494
    Location:221 → 361
    Abhydrolase; alpha/beta hydrolases

  3. NM_001271421.1 → NP_001258350.1  bifunctional epoxide hydrolase 2 isoform d

    See identical proteins and their annotated locations for NP_001258350.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. This variant is considered to be 5' complete based on evidence from PMID: 17900570. The encoded isoform (d) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AC126272, EF597241
    Consensus CDS
    CCDS88693.1
    UniProtKB/TrEMBL
    A8JYK8, Q3UQ71
    Related
    ENSMUSP00000152894.2, ENSMUST00000225309.2
    Conserved Domains (4) summary
    cd01427
    Location:45 → 137
    HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
    TIGR01509
    Location:1 → 137
    HAD-SF-IA-v3; haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED
    pfam00561
    Location:191 → 464
    Abhydrolase_1; alpha/beta hydrolase fold
    cl21494
    Location:173 → 313
    Abhydrolase; alpha/beta hydrolases

  4. NM_007940.4 → NP_031966.2  bifunctional epoxide hydrolase 2 isoform a

    See identical proteins and their annotated locations for NP_031966.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC126272, AK142714
    Consensus CDS
    CCDS27218.1
    UniProtKB/Swiss-Prot
    P34914, Q8CGV0
    UniProtKB/TrEMBL
    Q3UQ71
    Related
    ENSMUSP00000069209.2, ENSMUST00000070515.2
    Conserved Domains (2) summary
    cd02603
    Location:3 → 214
    HAD_sEH-N_like; N-terminal lipase phosphatase domain of human soluble epoxide hydrolase, Escherichia coli YihX/HAD4 alpha-D-glucose 1-phosphate phosphatase, and related domains, may be inactive
    pfam00561
    Location:257 → 530
    Abhydrolase_1; alpha/beta hydrolase fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    66321821..66361971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34914.2 GenPept UniProtKB/Swiss-Prot:P34914

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