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Epha4 Eph receptor A4 [ Mus musculus (house mouse) ]

Gene ID: 13838, updated on 18-Apr-2024

Summary

Official Symbol
Epha4provided by MGI
Official Full Name
Eph receptor A4provided by MGI
Primary source
MGI:MGI:98277
See related
Ensembl:ENSMUSG00000026235 AllianceGenome:MGI:98277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
rb; Sek; Cek8; Hek8; Sek1; Tyro1; 2900005C20Rik
Summary
Enables GPI-linked ephrin receptor activity; identical protein binding activity; and transmembrane-ephrin receptor activity. Involved in several processes, including axon development; positive regulation of protein kinase activity; and regulation of neuron projection development. Acts upstream of or within adult walking behavior; axon guidance; and nephric duct morphogenesis. Located in several cellular components, including Schaffer collateral - CA1 synapse; early endosome membrane; and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Orthologous to human EPHA4 (EPH receptor A4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 17.3), whole brain E14.5 (RPKM 14.7) and 13 other tissues See more
Orthologs
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Genomic context

Location:
1 C4; 1 39.55 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (77343819..77491763, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (77367182..77515107, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01385 Neighboring gene STARR-seq mESC enhancer starr_01386 Neighboring gene transcription factor Dp 1, pseudogene Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01387 Neighboring gene STARR-seq mESC enhancer starr_01388 Neighboring gene STARR-seq mESC enhancer starr_01400 Neighboring gene STARR-seq mESC enhancer starr_01406 Neighboring gene STARR-seq mESC enhancer starr_01407 Neighboring gene STARR-seq mESC enhancer starr_01412 Neighboring gene Epha4 upstream enhancer in rhombomeres Neighboring gene enhancer upstream of Epha4 Neighboring gene STARR-seq mESC enhancer starr_01413 Neighboring gene microRNA 6352 Neighboring gene predicted gene, 32793 Neighboring gene STARR-seq mESC enhancer starr_01414 Neighboring gene predicted gene, 32974

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Targeted (16)  1 citation
  • Spontaneous (2) 
  • Endonuclease-mediated (1) 
  • Chemically induced (ENU) (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DH domain binding ISO
Inferred from Sequence Orthology
more info
 
enables GPI-linked ephrin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables PH domain binding ISO
Inferred from Sequence Orthology
more info
 
enables ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane-ephrin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in adherens junction organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adult walking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cochlea development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in corticospinal tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in fasciculation of motor neuron axon IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fasciculation of sensory neuron axon IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within innervation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of axon regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of long-term synaptic potentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of proteolysis involved in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nephric duct morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection fasciculation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron projection guidance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Rho guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein tyrosine kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of modification of synaptic structure IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of modification of synaptic structure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synapse pruning ISO
Inferred from Sequence Orthology
more info
 
involved_in synapse pruning EXP
Inferred from Experiment
more info
PubMed 
involved_in synapse pruning IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synapse pruning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IEP
Inferred from Expression Pattern
more info
PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic membrane IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane IEP
Inferred from Expression Pattern
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ephrin type-A receptor 4
Names
tyrosine-protein kinase receptor MPK-3
tyrosine-protein kinase receptor SEK-1
NP_031962.2
XP_006496470.1
XP_006496471.1
XP_036015237.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007936.3NP_031962.2  ephrin type-A receptor 4 precursor

    See identical proteins and their annotated locations for NP_031962.2

    Status: VALIDATED

    Source sequence(s)
    AC164875, AK147698, X65138
    Consensus CDS
    CCDS35627.1
    UniProtKB/Swiss-Prot
    Q03137, Q80VZ2
    UniProtKB/TrEMBL
    Q99KA8
    Related
    ENSMUSP00000027451.7, ENSMUST00000027451.13
    Conserved Domains (7) summary
    cd09545
    Location:911981
    SAM_EPH-A4; SAM domain of EPH-A4 subfamily of tyrosine kinase receptors
    smart00454
    Location:915975
    SAM; Sterile alpha motif
    cd10482
    Location:30203
    EphR_LBD_A4; Ligand Binding Domain of Ephrin type-A Receptor 4
    cd00063
    Location:441532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:616882
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam07714
    Location:621878
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:562616
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    77343819..77491763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496407.4XP_006496470.1  ephrin type-A receptor 4 isoform X1

    UniProtKB/TrEMBL
    Q99KA8
    Conserved Domains (5) summary
    cd10482
    Location:30203
    EphR_LBD_A4; Ligand Binding Domain of Ephrin type-A Receptor 4
    cd00063
    Location:441532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:616882
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam14575
    Location:562616
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl15755
    Location:911949
    SAM_superfamily; SAM (Sterile alpha motif )
  2. XM_006496408.3XP_006496471.1  ephrin type-A receptor 4 isoform X2

    UniProtKB/TrEMBL
    Q99KA8
    Conserved Domains (5) summary
    cd09545
    Location:860930
    SAM_EPH-A4; SAM domain of EPH-A4 subfamily of tyrosine kinase receptors
    cd10473
    Location:3152
    EphR_LBD_A; Ligand Binding Domain of Ephrin type-A Receptors
    cd00063
    Location:390481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:565831
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam14575
    Location:511565
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  3. XM_036159344.1XP_036015237.1  ephrin type-A receptor 4 isoform X3

    UniProtKB/TrEMBL
    Q99KA8
    Conserved Domains (5) summary
    cd10473
    Location:3152
    EphR_LBD_A; Ligand Binding Domain of Ephrin type-A Receptors
    cd00063
    Location:390481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:565831
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam14575
    Location:511567
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl15755
    Location:860898
    SAM_superfamily; SAM (Sterile alpha motif )