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Epc1 enhancer of polycomb homolog 1 [ Mus musculus (house mouse) ]

Gene ID: 13831, updated on 8-Dec-2022

Summary

Official Symbol
Epc1provided by MGI
Official Full Name
enhancer of polycomb homolog 1provided by MGI
Primary source
MGI:MGI:1278322
See related
Ensembl:ENSMUSG00000024240 AllianceGenome:MGI:1278322
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mir-1893; 2400007E14Rik; 5730566F07Rik; A930032N02Rik
Summary
Predicted to contribute to histone acetyltransferase activity. Predicted to be involved in histone acetylation and regulation of transcription, DNA-templated. Predicted to act upstream of or within negative regulation of gene expression, epigenetic; positive regulation of striated muscle cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be part of Piccolo NuA4 histone acetyltransferase complex. Is expressed in several structures, including blood vessel endothelium; brain; heart; retina; and skeletal muscle. Orthologous to human EPC1 (enhancer of polycomb homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 19.2), whole brain E14.5 (RPKM 18.8) and 28 other tissues See more
Orthologs
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Genomic context

See Epc1 in Genome Data Viewer
Location:
18; 18 A1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (6435951..6516108, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (6435951..6516108, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27, pseudogene 3 Neighboring gene prothymosin alpha pseudogene Neighboring gene microRNA 1893 Neighboring gene charged multivesicular body protein 3 pseudogene Neighboring gene RIKEN cDNA 4921524L21 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin-protein adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H2A acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H4 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone acetylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of striated muscle cell differentiation ISA
Inferred from Sequence Alignment
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISA
Inferred from Sequence Alignment
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of chromatin organization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of growth IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sperm DNA condensation ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatid development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of Piccolo NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Piccolo NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
enhancer of polycomb homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276350.1NP_001263279.1  enhancer of polycomb homolog 1 isoform 3

    See identical proteins and their annotated locations for NP_001263279.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons in the central and 3' coding regions and includes an alternate 3' terminal exon, resulting in a novel 3' coding region and 3' UTR, compared to variant 2. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AC139300, AK040254, AV356347, BB343428, BC038636, BC055805
    Consensus CDS
    CCDS70868.1
    UniProtKB/Swiss-Prot
    Q8C9X6
    UniProtKB/TrEMBL
    A0A6P5P1T3, A0A8C6HIX5, Q6PBH3, Q7TNR8
    Related
    ENSMUSP00000060599.6, ENSMUST00000050542.6
    Conserved Domains (1) summary
    pfam10513
    Location:651
    EPL1; Enhancer of polycomb-like
  2. NM_007935.2NP_031961.1  enhancer of polycomb homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_031961.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and in the 5' coding region, compared to variant 2. It encodes isoform 1 which is shorter and has a distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    AI849475, AK148194, AK149317, BB207261, BM936825, DV652878
    Consensus CDS
    CCDS37726.1
    UniProtKB/Swiss-Prot
    Q8C9X6
    UniProtKB/TrEMBL
    Q3UEV1, Q3UG01
    Related
    ENSMUSP00000111536.3, ENSMUST00000115870.9
    Conserved Domains (2) summary
    pfam06752
    Location:572763
    E_Pc_C; Enhancer of Polycomb C-terminus
    pfam10513
    Location:198
    EPL1; Enhancer of polycomb-like
  3. NM_027497.3NP_081773.1  enhancer of polycomb homolog 1 isoform 2

    See identical proteins and their annotated locations for NP_081773.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AC139300, AF079765, AK040254
    Consensus CDS
    CCDS29041.1
    UniProtKB/Swiss-Prot
    Q8C9X6, Q9Z299
    Related
    ENSMUSP00000028100.7, ENSMUST00000028100.13
    Conserved Domains (2) summary
    pfam06752
    Location:622813
    E_Pc_C; Enhancer of Polycomb C-terminus
    pfam10513
    Location:7148
    EPL1; Enhancer of polycomb-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    6435951..6516108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)