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RNF183 ring finger protein 183 [ Homo sapiens (human) ]

Gene ID: 138065, updated on 26-Oct-2022

Summary

Official Symbol
RNF183provided by HGNC
Official Full Name
ring finger protein 183provided by HGNC
Primary source
HGNC:HGNC:28721
See related
Ensembl:ENSG00000165188 AllianceGenome:HGNC:28721
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables ubiquitin protein ligase activity. Involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; protein ubiquitination; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in gall bladder (RPKM 1.5), kidney (RPKM 1.3) and 7 other tissues See more
Orthologs
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Genomic context

See RNF183 in Genome Data Viewer
Location:
9q32
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (113297093..113303376, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (125495894..125502177, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (116059373..116065656, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene cell division cycle 26 Neighboring gene pre-mRNA processing factor 4 Neighboring gene WD repeat domain 31 Neighboring gene B-box and SPRY domain containing

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC4734, FLJ31197

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cis-Golgi network membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF183
Names
probable E3 ubiquitin-protein ligase RNF183
NP_001358163.1
NP_001358164.1
NP_001358165.1
NP_001358166.1
NP_001374497.1
NP_001374498.1
NP_659488.2
XP_024303178.1
XP_024303179.1
XP_024303180.1
XP_047278717.1
XP_047278718.1
XP_047278719.1
XP_047278720.1
XP_047278721.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371234.1NP_001358163.1  E3 ubiquitin-protein ligase RNF183

    Status: VALIDATED

    Source sequence(s)
    AL449305
    Consensus CDS
    CCDS43866.1
    UniProtKB/Swiss-Prot
    Q96D59
    UniProtKB/TrEMBL
    A0A024R834
    Related
    ENSP00000420740.1, ENST00000416588.2
    Conserved Domains (1) summary
    cd16556
    Location:1263
    RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins
  2. NM_001371235.1NP_001358164.1  E3 ubiquitin-protein ligase RNF183

    Status: VALIDATED

    Source sequence(s)
    AL449305
    Consensus CDS
    CCDS43866.1
    UniProtKB/Swiss-Prot
    Q96D59
    UniProtKB/TrEMBL
    A0A024R834
    Conserved Domains (1) summary
    cd16556
    Location:1263
    RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins
  3. NM_001371236.1NP_001358165.1  E3 ubiquitin-protein ligase RNF183

    Status: VALIDATED

    Source sequence(s)
    AL449305
    Consensus CDS
    CCDS43866.1
    UniProtKB/Swiss-Prot
    Q96D59
    UniProtKB/TrEMBL
    A0A024R834
    Related
    ENSP00000417943.1, ENST00000297894.5
    Conserved Domains (1) summary
    cd16556
    Location:1263
    RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins
  4. NM_001371237.1NP_001358166.1  E3 ubiquitin-protein ligase RNF183

    Status: VALIDATED

    Source sequence(s)
    AL449305
    Consensus CDS
    CCDS43866.1
    UniProtKB/Swiss-Prot
    Q96D59
    UniProtKB/TrEMBL
    A0A024R834
    Related
    ENSP00000508293.1, ENST00000489339.2
    Conserved Domains (1) summary
    cd16556
    Location:1263
    RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins
  5. NM_001387568.1NP_001374497.1  E3 ubiquitin-protein ligase RNF183

    Status: VALIDATED

    Source sequence(s)
    AL449305
    Consensus CDS
    CCDS43866.1
    UniProtKB/Swiss-Prot
    Q96D59
    UniProtKB/TrEMBL
    A0A024R834
    Conserved Domains (1) summary
    cd16556
    Location:1263
    RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins
  6. NM_001387569.1NP_001374498.1  E3 ubiquitin-protein ligase RNF183

    Status: VALIDATED

    Source sequence(s)
    AL449305
    Consensus CDS
    CCDS43866.1
    UniProtKB/Swiss-Prot
    Q96D59
    UniProtKB/TrEMBL
    A0A024R834
    Conserved Domains (1) summary
    cd16556
    Location:1263
    RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins
  7. NM_145051.5NP_659488.2  E3 ubiquitin-protein ligase RNF183

    See identical proteins and their annotated locations for NP_659488.2

    Status: VALIDATED

    Source sequence(s)
    AL449305
    Consensus CDS
    CCDS43866.1
    UniProtKB/Swiss-Prot
    Q96D59
    UniProtKB/TrEMBL
    A0A024R834
    Conserved Domains (1) summary
    cd16556
    Location:1263
    RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    113297093..113303376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422765.1XP_047278721.1  E3 ubiquitin-protein ligase RNF183 isoform X1

    UniProtKB/Swiss-Prot
    Q96D59
    UniProtKB/TrEMBL
    A0A024R834
    Related
    ENSP00000419454.1, ENST00000478815.1
  2. XM_024447412.2XP_024303180.1  E3 ubiquitin-protein ligase RNF183 isoform X1

    UniProtKB/Swiss-Prot
    Q96D59
    UniProtKB/TrEMBL
    A0A024R834
    Conserved Domains (1) summary
    cd16556
    Location:1263
    RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins
  3. XM_024447411.2XP_024303179.1  E3 ubiquitin-protein ligase RNF183 isoform X1

    UniProtKB/Swiss-Prot
    Q96D59
    UniProtKB/TrEMBL
    A0A024R834
    Conserved Domains (1) summary
    cd16556
    Location:1263
    RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins
  4. XM_047422763.1XP_047278719.1  E3 ubiquitin-protein ligase RNF183 isoform X1

    UniProtKB/Swiss-Prot
    Q96D59
    UniProtKB/TrEMBL
    A0A024R834
  5. XM_047422764.1XP_047278720.1  E3 ubiquitin-protein ligase RNF183 isoform X1

    UniProtKB/Swiss-Prot
    Q96D59
    UniProtKB/TrEMBL
    A0A024R834
  6. XM_047422762.1XP_047278718.1  E3 ubiquitin-protein ligase RNF183 isoform X1

    UniProtKB/Swiss-Prot
    Q96D59
    UniProtKB/TrEMBL
    A0A024R834
  7. XM_047422761.1XP_047278717.1  E3 ubiquitin-protein ligase RNF183 isoform X1

    UniProtKB/Swiss-Prot
    Q96D59
    UniProtKB/TrEMBL
    A0A024R834
  8. XM_024447410.1XP_024303178.1  E3 ubiquitin-protein ligase RNF183 isoform X1

    UniProtKB/Swiss-Prot
    Q96D59
    UniProtKB/TrEMBL
    A0A024R834
    Conserved Domains (1) summary
    cd16556
    Location:1263
    RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    125495894..125502177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)