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Eng endoglin [ Mus musculus (house mouse) ]

Gene ID: 13805, updated on 22-Nov-2020

Summary

Official Symbol
Engprovided by MGI
Official Full Name
endoglinprovided by MGI
Primary source
MGI:MGI:95392
See related
Ensembl:ENSMUSG00000026814
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
En; Endo; CD105; AI528660; AI662476; S-endoglin
Expression
Broad expression in lung adult (RPKM 303.5), adrenal adult (RPKM 138.1) and 16 other tissues See more
Orthologs

Genomic context

See Eng in Genome Data Viewer
Location:
2 B; 2 22.09 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32536607..32572681)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32646595..32682669)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (32502115..32538189)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 52551 Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Neighboring gene adenylate kinase 1 Neighboring gene microRNA 1954 Neighboring gene predicted gene, 26236 Neighboring gene folylpolyglutamyl synthetase Neighboring gene microRNA 8093 Neighboring gene cyclin-dependent kinase 9 (CDC2-related kinase) Neighboring gene microRNA 2861

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to BMP binding ISO
Inferred from Sequence Orthology
more info
 
coreceptor activity ISO
Inferred from Sequence Orthology
more info
 
galactose binding ISO
Inferred from Sequence Orthology
more info
 
glycosaminoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycosaminoglycan binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to transforming growth factor beta binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta binding IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
type I transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
type II transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
type II transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
atrial cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
atrioventricular canal morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac atrium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT cardiac jelly development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cell migration involved in endocardial cushion formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell motility ISO
Inferred from Sequence Orthology
more info
 
central nervous system vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
detection of hypoxia ISO
Inferred from Sequence Orthology
more info
 
dorsal aorta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocardial cushion morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT endocardial cushion to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial to mesenchymal transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epithelial to mesenchymal transition involved in endocardial cushion formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellular matrix constituent secretion ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
outflow tract septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of angiogenesis TAS
Traceable Author Statement
more info
PubMed 
positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular associated smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT regulation of cell proliferation involved in heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
smooth muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta receptor signaling pathway IC
Inferred by Curator
more info
PubMed 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
vascular associated smooth muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasculogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
venous blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ventricular trabecula myocardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
endothelial microparticle IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
endoglin
Names
cell surface MJ7/18 antigen
transmembrane glycoprotein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146348.1NP_001139820.1  endoglin isoform 3 precursor

    See identical proteins and their annotated locations for NP_001139820.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a protein (isoform 3) that is one amino acid shorter than isoform 1.
    Source sequence(s)
    AK151302, BY226445
    Consensus CDS
    CCDS50570.1
    UniProtKB/TrEMBL
    Q3UAM9
    Related
    ENSMUSP00000130585.2, ENSMUST00000167841.7
    Conserved Domains (1) summary
    smart00241
    Location:361501
    ZP; Zona pellucida (ZP) domain
  2. NM_001146350.1NP_001139822.1  endoglin isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, resulting in a protein (isoform 2) that has a shorter and distinct C-terminus, compared to isoform 1. This is also known as S-endoglin.
    Source sequence(s)
    AK151302, AL772271, BB851508, BY226445
    Consensus CDS
    CCDS50569.1
    UniProtKB/TrEMBL
    F7A1B4, Q3UAM9
    Related
    ENSMUSP00000108897.2, ENSMUST00000113272.7
    Conserved Domains (1) summary
    smart00241
    Location:362502
    ZP; Zona pellucida (ZP) domain
  3. NM_007932.2NP_031958.2  endoglin isoform 1 precursor

    See identical proteins and their annotated locations for NP_031958.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This is also known as L-endoglin.
    Source sequence(s)
    AK151302, BB851508, BY226445
    Consensus CDS
    CCDS15925.1
    UniProtKB/Swiss-Prot
    Q63961
    UniProtKB/TrEMBL
    Q3UAM9
    Related
    ENSMUSP00000009705.7, ENSMUST00000009705.13
    Conserved Domains (1) summary
    smart00241
    Location:362502
    ZP; Zona pellucida (ZP) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    32536607..32572681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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