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Enc1 ectodermal-neural cortex 1 [ Mus musculus (house mouse) ]

Gene ID: 13803, updated on 2-Nov-2024

Summary

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Official Symbol
Enc1provided by MGI
Official Full Name
ectodermal-neural cortex 1provided by MGI
Primary source
MGI:MGI:109610
See related
Ensembl:ENSMUSG00000041773 AllianceGenome:MGI:109610
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nrpb; PIG10
Summary
Predicted to enable actin binding activity. Predicted to be involved in several processes, including negative regulation of translation; positive regulation of neuron projection development; and proteasomal ubiquitin-independent protein catabolic process. Predicted to be located in chromatin; neuronal cell body; and nuclear lumen. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Orthologous to human ENC1 (ectodermal-neural cortex 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 112.0), whole brain E14.5 (RPKM 85.4) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Enc1 in Genome Data Viewer
Location:
13 50.66 cM; 13 D1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (97377613..97389548)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (97241105..97253040)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 169, member A Neighboring gene STARR-positive B cell enhancer ABC_E3094 Neighboring gene NSA2 ribosome biogenesis homolog Neighboring gene G elongation factor, mitochondrial 2 Neighboring gene STARR-seq mESC enhancer starr_35367 Neighboring gene hexosaminidase B Neighboring gene STARR-seq mESC enhancer starr_35370 Neighboring gene STARR-seq mESC enhancer starr_35377 Neighboring gene predicted gene, 33390 Neighboring gene STARR-seq mESC enhancer starr_35381 Neighboring gene STARR-seq mESC enhancer starr_35383 Neighboring gene predicted gene, 33447

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Assignment of the ectodermal-neural cortex 1 gene (Enc1) to mouse chromosome band 13D1 by fluorescence in situ hybridization. Hernandez M, et al. Cytogenet Cell Genet, 2000. PMID 10965111
  2. Pallial expression of Enc1 RNA in postnatal mouse telencephalon. García-Calero E, et al. Brain Res Bull, 2005 Sep 15. PMID 16144629
  3. ENC-1: a novel mammalian kelch-related gene specifically expressed in the nervous system encodes an actin-binding protein. Hernandez MC, et al. J Neurosci, 1997 May 1. PMID 9096139, Free PMC Article
  4. Ectodermal-Neural Cortex 1 Isoforms Have Contrasting Effects on MC3T3-E1 Osteoblast Mineralization and Gene Expression. Worton LE, et al. J Cell Biochem, 2017 Aug. PMID 27996212
  5. NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation. Kim TA, et al. J Cell Biol, 1998 May 4. PMID 9566959, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasomal ubiquitin-independent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasomal ubiquitin-independent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasomal ubiquitin-independent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul3-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ectoderm-neural cortex protein 1
Names
ENC-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007930.4 → NP_031956.3  ectoderm-neural cortex protein 1

    See identical proteins and their annotated locations for NP_031956.3

    Status: VALIDATED

    Source sequence(s)
    AK132173, AV465735
    Consensus CDS
    CCDS26710.1
    UniProtKB/Swiss-Prot
    O35709, Q8C7V2
    UniProtKB/TrEMBL
    Q8BRG4
    Related
    ENSMUSP00000038783.8, ENSMUST00000041623.9
    Conserved Domains (4) summary
    PHA03098
    Location:48 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330 → 374
    Kelch; KELCH repeat [structural motif]
    cd18267
    Location:6 → 152
    BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)
    cd18515
    Location:145 → 242
    BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    97377613..97389548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247139.1 → XP_030102999.1  ectoderm-neural cortex protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O35709, Q8C7V2
    UniProtKB/TrEMBL
    Q8BRG4
    Conserved Domains (4) summary
    PHA03098
    Location:48 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330 → 374
    Kelch; KELCH repeat [structural motif]
    cd18267
    Location:6 → 152
    BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)
    cd18515
    Location:145 → 242
    BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)

  2. XM_030247137.1 → XP_030102997.1  ectoderm-neural cortex protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O35709, Q8C7V2
    UniProtKB/TrEMBL
    Q8BRG4
    Conserved Domains (4) summary
    PHA03098
    Location:48 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330 → 374
    Kelch; KELCH repeat [structural motif]
    cd18267
    Location:6 → 152
    BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)
    cd18515
    Location:145 → 242
    BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)

  3. XM_030247138.1 → XP_030102998.1  ectoderm-neural cortex protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O35709, Q8C7V2
    UniProtKB/TrEMBL
    Q8BRG4
    Conserved Domains (4) summary
    PHA03098
    Location:48 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330 → 374
    Kelch; KELCH repeat [structural motif]
    cd18267
    Location:6 → 152
    BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)
    cd18515
    Location:145 → 242
    BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35709.2 GenPept UniProtKB/Swiss-Prot:O35709

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