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Enc1 ectodermal-neural cortex 1 [ Mus musculus (house mouse) ]

Gene ID: 13803, updated on 18-Apr-2024

Summary

Official Symbol
Enc1provided by MGI
Official Full Name
ectodermal-neural cortex 1provided by MGI
Primary source
MGI:MGI:109610
See related
Ensembl:ENSMUSG00000041773 AllianceGenome:MGI:109610
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nrpb; PIG10
Summary
Predicted to enable actin binding activity. Predicted to be involved in cellular protein metabolic process; negative regulation of translation; and positive regulation of neuron projection development. Predicted to be located in chromatin; neuronal cell body; and nuclear lumen. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ENC1 (ectodermal-neural cortex 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 112.0), whole brain E14.5 (RPKM 85.4) and 6 other tissues See more
Orthologs
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Genomic context

Location:
13 50.66 cM; 13 D1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (97377613..97389548)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (97241105..97253040)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 169, member A Neighboring gene STARR-positive B cell enhancer ABC_E3094 Neighboring gene NSA2 ribosome biogenesis homolog Neighboring gene G elongation factor, mitochondrial 2 Neighboring gene STARR-seq mESC enhancer starr_35367 Neighboring gene hexosaminidase B Neighboring gene STARR-seq mESC enhancer starr_35370 Neighboring gene STARR-seq mESC enhancer starr_35377 Neighboring gene predicted gene, 33390 Neighboring gene STARR-seq mESC enhancer starr_35381 Neighboring gene STARR-seq mESC enhancer starr_35383 Neighboring gene predicted gene, 33447

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ectoderm-neural cortex protein 1
Names
ENC-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007930.4NP_031956.3  ectoderm-neural cortex protein 1

    See identical proteins and their annotated locations for NP_031956.3

    Status: VALIDATED

    Source sequence(s)
    AK132173, AV465735
    Consensus CDS
    CCDS26710.1
    UniProtKB/Swiss-Prot
    O35709, Q8C7V2
    UniProtKB/TrEMBL
    Q8BRG4
    Related
    ENSMUSP00000038783.8, ENSMUST00000041623.9
    Conserved Domains (4) summary
    PHA03098
    Location:48566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330374
    Kelch; KELCH repeat [structural motif]
    cd18267
    Location:6152
    BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)
    cd18515
    Location:145242
    BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    97377613..97389548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247139.1XP_030102999.1  ectoderm-neural cortex protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O35709, Q8C7V2
    UniProtKB/TrEMBL
    Q8BRG4
    Conserved Domains (4) summary
    PHA03098
    Location:48566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330374
    Kelch; KELCH repeat [structural motif]
    cd18267
    Location:6152
    BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)
    cd18515
    Location:145242
    BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)
  2. XM_030247137.1XP_030102997.1  ectoderm-neural cortex protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O35709, Q8C7V2
    UniProtKB/TrEMBL
    Q8BRG4
    Conserved Domains (4) summary
    PHA03098
    Location:48566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330374
    Kelch; KELCH repeat [structural motif]
    cd18267
    Location:6152
    BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)
    cd18515
    Location:145242
    BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)
  3. XM_030247138.1XP_030102998.1  ectoderm-neural cortex protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O35709, Q8C7V2
    UniProtKB/TrEMBL
    Q8BRG4
    Conserved Domains (4) summary
    PHA03098
    Location:48566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330374
    Kelch; KELCH repeat [structural motif]
    cd18267
    Location:6152
    BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)
    cd18515
    Location:145242
    BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)