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En2 engrailed 2 [ Mus musculus (house mouse) ]

Gene ID: 13799, updated on 27-Sep-2022

Summary

Official Symbol
En2provided by MGI
Official Full Name
engrailed 2provided by MGI
Primary source
MGI:MGI:95390
See related
Ensembl:ENSMUSG00000039095 AllianceGenome:MGI:95390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
En-2; mo-En-2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic brain development and negative regulation of neuron apoptotic process. Acts upstream of or within nervous system development and positive regulation of transcription by RNA polymerase II. Predicted to be located in fibrillar center; membrane; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; gut; and limb bud. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 21.8), CNS E11.5 (RPKM 13.0) and 3 other tissues See more
Orthologs
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Genomic context

See En2 in Genome Data Viewer
Location:
5 B1; 5 13.94 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (28370694..28377188)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (28165696..28172190)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35223 Neighboring gene insulin induced gene 1 Neighboring gene predicted gene, 35055 Neighboring gene predicted gene, 52808 Neighboring gene predicted gene, 42242

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (10)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within dopaminergic neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in dopaminergic neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in embryonic brain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hindbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within midbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
homeobox protein engrailed-2
Names
homeobox protein en-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395060.1NP_001381989.1  homeobox protein engrailed-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC129184
  2. NM_010134.4NP_034264.1  homeobox protein engrailed-2 isoform 1

    See identical proteins and their annotated locations for NP_034264.1

    Status: VALIDATED

    Source sequence(s)
    AI844870, AK157766
    Consensus CDS
    CCDS19143.1
    UniProtKB/Swiss-Prot
    P09066
    UniProtKB/TrEMBL
    Q3TZM2
    Related
    ENSMUSP00000036761.8, ENSMUST00000036177.9
    Conserved Domains (2) summary
    pfam00046
    Location:238291
    Homeobox; Homeobox domain
    pfam10525
    Location:293322
    Engrail_1_C_sig; Engrailed homeobox C-terminal signature domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    28370694..28377188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)