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Eln elastin [ Mus musculus (house mouse) ]

Gene ID: 13717, updated on 26-Mar-2024

Summary

Official Symbol
Elnprovided by MGI
Official Full Name
elastinprovided by MGI
Primary source
MGI:MGI:95317
See related
Ensembl:ENSMUSG00000029675 AllianceGenome:MGI:95317
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E030024M20Rik
Summary
This gene encodes elastin, the extracellular matrix protein that forms a major structural component of several tissues including lungs and arterial walls. Cleavage of the signal peptide from the encoded precursor generates soluble tropoelastin which undergoes lysine-derived crosslinking to form elastin polymers. Mice lacking the encoded protein exhibit defective lung development, and die of an obstructive arterial disease resulting from subendothelial cell proliferation and reorganization of smooth muscle. [provided by RefSeq, Aug 2015]
Expression
Broad expression in lung adult (RPKM 131.3), limb E14.5 (RPKM 72.1) and 17 other tissues See more
Orthologs
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Genomic context

See Eln in Genome Data Viewer
Location:
5 G2; 5 74.76 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (134731449..134776300, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134702595..134747368, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4H Neighboring gene LIM domain kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1309 Neighboring gene predicted gene 10369 Neighboring gene STARR-positive B cell enhancer mm9_chr5:135180028-135180329 Neighboring gene predicted gene, 30003 Neighboring gene STARR-seq mESC enhancer starr_14552 Neighboring gene transmembrane protein 270 Neighboring gene claudin 13

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007925.4NP_031951.2  elastin precursor

    See identical proteins and their annotated locations for NP_031951.2

    Status: REVIEWED

    Source sequence(s)
    AA183434, AC091250, AK041860
    Consensus CDS
    CCDS19725.1
    UniProtKB/Swiss-Prot
    P54320, Q8C9L8
    UniProtKB/TrEMBL
    Q9ESZ9
    Related
    ENSMUSP00000015138.10, ENSMUST00000015138.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    134731449..134776300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240855.3XP_011239157.1  elastin isoform X1

    UniProtKB/TrEMBL
    Q9ESZ9