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Elf1 E74 like ETS transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 13709, updated on 6-Jun-2024

Summary

Official Symbol
Elf1provided by MGI
Official Full Name
E74 like ETS transcription factor 1provided by MGI
Primary source
MGI:MGI:107180
See related
Ensembl:ENSMUSG00000036461 AllianceGenome:MGI:107180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p70; Sts1; Elf-1; mElf-1
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of T cell receptor signaling pathway and regulation of cytokine production. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ELF1 (E74 like ETS transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 22.3), bladder adult (RPKM 13.4) and 26 other tissues See more
Orthologs
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Genomic context

See Elf1 in Genome Data Viewer
Location:
14 D3; 14 42.67 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (79718619..79819916)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (79481174..79582491)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene mitochondrial translational release factor 1 Neighboring gene kelch repeat and BTB (POZ) domain containing 7 Neighboring gene STARR-positive B cell enhancer ABC_E2429 Neighboring gene kelch repeat and BTB (POZ) domain containing 6 Neighboring gene WW domain binding protein 4 Neighboring gene nuclear encoded tRNA glutamic acid 4 (anticodon TTC) Neighboring gene claspin homolog pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr14:79915269-79915570 Neighboring gene STARR-positive B cell enhancer ABC_E9411 Neighboring gene STARR-positive B cell enhancer ABC_E9903 Neighboring gene STARR-seq mESC enhancer starr_37267 Neighboring gene STARR-positive B cell enhancer ABC_E2430 Neighboring gene SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) Neighboring gene chondromodulin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ETS-related transcription factor Elf-1
Names
E74-like factor 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286411.2NP_001273340.1  ETS-related transcription factor Elf-1 isoform 1

    See identical proteins and their annotated locations for NP_001273340.1

    Status: VALIDATED

    Source sequence(s)
    AC129216, AC151994
    Consensus CDS
    CCDS27301.1
    UniProtKB/Swiss-Prot
    Q60775
    UniProtKB/TrEMBL
    Q3U1B2, Q3V1H4
    Related
    ENSMUSP00000106459.2, ENSMUST00000110835.3
    Conserved Domains (2) summary
    smart00413
    Location:207289
    ETS; erythroblast transformation specific domain
    pfam12310
    Location:2111
    Elf-1_N; Transcription factor protein N terminal
  2. NM_001286412.2NP_001273341.1  ETS-related transcription factor Elf-1 isoform 2

    See identical proteins and their annotated locations for NP_001273341.1

    Status: VALIDATED

    Source sequence(s)
    AC129216, AC151994
    Consensus CDS
    CCDS88722.1
    UniProtKB/TrEMBL
    A0A2I3BPX9, Q3U1B2
    Related
    ENSMUSP00000153956.2, ENSMUST00000227192.2
    Conserved Domains (2) summary
    smart00413
    Location:170252
    ETS; erythroblast transformation specific domain
    pfam12310
    Location:269
    Elf-1_N; Transcription factor protein N terminal
  3. NM_001422240.1NP_001409169.1  ETS-related transcription factor Elf-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC129216, AC151994
    UniProtKB/Swiss-Prot
    Q60775
    UniProtKB/TrEMBL
    Q3U1B2, Q3V1H4
  4. NM_001422241.1NP_001409170.1  ETS-related transcription factor Elf-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC129216, AC151994
    UniProtKB/Swiss-Prot
    Q60775
    UniProtKB/TrEMBL
    Q3U1B2, Q3V1H4
  5. NM_001422242.1NP_001409171.1  ETS-related transcription factor Elf-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC129216, AC151994
    UniProtKB/Swiss-Prot
    Q60775
    UniProtKB/TrEMBL
    Q3U1B2, Q3V1H4
  6. NM_001422243.1NP_001409172.1  ETS-related transcription factor Elf-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC129216, AC151994
    UniProtKB/TrEMBL
    A0A2I3BPX9, Q3U1B2
  7. NM_001422244.1NP_001409173.1  ETS-related transcription factor Elf-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC129216, AC151994
    UniProtKB/TrEMBL
    Q3UQ47
  8. NM_007920.5NP_031946.1  ETS-related transcription factor Elf-1 isoform 1

    See identical proteins and their annotated locations for NP_031946.1

    Status: VALIDATED

    Source sequence(s)
    AC129216, AC151994
    Consensus CDS
    CCDS27301.1
    UniProtKB/Swiss-Prot
    Q60775
    UniProtKB/TrEMBL
    Q3U1B2, Q3V1H4
    Related
    ENSMUSP00000046515.6, ENSMUST00000040131.13
    Conserved Domains (2) summary
    smart00413
    Location:207289
    ETS; erythroblast transformation specific domain
    pfam12310
    Location:2111
    Elf-1_N; Transcription factor protein N terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    79718619..79819916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)