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SSC4D scavenger receptor cysteine rich family member with 4 domains [ Homo sapiens (human) ]

Gene ID: 136853, updated on 25-Jan-2022

Summary

Official Symbol
SSC4Dprovided by HGNC
Official Full Name
scavenger receptor cysteine rich family member with 4 domainsprovided by HGNC
Primary source
HGNC:HGNC:14461
See related
Ensembl:ENSG00000146700 MIM:607639; AllianceGenome:HGNC:14461
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRCRB4D; S4D-SRCRB; SRCRB-S4D
Summary
The scavenger receptor cysteine-rich (SRCR) superfamily is an ancient and highly conserved group of cell surface and/or secreted proteins, some of which are involved in the development of the immune system and the regulation of both innate and adaptive immune responses. Group B SRCR domains usually contain 8 regularly spaced cysteines that give rise to a well-defined intradomain disulfide-bond pattern.[supplied by OMIM, Apr 2004]
Expression
Broad expression in kidney (RPKM 1.3), thyroid (RPKM 1.0) and 21 other tissues See more
Orthologs
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Genomic context

See SSC4D in Genome Data Viewer
Location:
7q11.23
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (76389337..76410025, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (76018654..76039014, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 14050 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma Neighboring gene Sharpr-MPRA regulatory region 7220 Neighboring gene zona pellucida glycoprotein 3 Neighboring gene deltex E3 ubiquitin ligase 2 Neighboring gene farnesyl diphosphate synthase pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
scavenger receptor cysteine-rich domain-containing group B protein
Names
SRCRB4D
four scavenger receptor cysteine-rich domains-containing protein
scavenger receptor cysteine rich domain containing, group B (4 domains)
scavenger receptor cysteine rich family, 4 domains
scavenger receptor cysteine-rich protein SRCRB-S4D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080744.2NP_542782.1  scavenger receptor cysteine-rich domain-containing group B protein precursor

    See identical proteins and their annotated locations for NP_542782.1

    Status: VALIDATED

    Source sequence(s)
    AC005522, AJ312755
    Consensus CDS
    CCDS5585.1
    UniProtKB/Swiss-Prot
    Q8WTU2
    Related
    ENSP00000275560.3, ENST00000275560.4
    Conserved Domains (2) summary
    smart00202
    Location:473573
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:478572
    SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    76389337..76410025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011750.1XP_016867239.1  scavenger receptor cysteine-rich domain-containing group B protein isoform X2

  2. XM_024446664.1XP_024302432.1  scavenger receptor cysteine-rich domain-containing group B protein isoform X1

    Conserved Domains (1) summary
    smart00202
    Location:502602
    SR; Scavenger receptor Cys-rich
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