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Efna1 ephrin A1 [ Mus musculus (house mouse) ]

Gene ID: 13636, updated on 8-Feb-2024

Summary

Official Symbol
Efna1provided by MGI
Official Full Name
ephrin A1provided by MGI
Primary source
MGI:MGI:103236
See related
Ensembl:ENSMUSG00000027954 AllianceGenome:MGI:103236
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B61; Efl1; Epl1; Eplg1; Lerk1
Summary
Enables ephrin receptor binding activity. Involved in several processes, including heart valve morphogenesis; negative regulation of dendritic spine morphogenesis; and regulation of blood vessel endothelial cell migration. Acts upstream of or within several processes, including ephrin receptor signaling pathway; nervous system development; and regulation of MAPK cascade. Is anchored component of plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to human EFNA1 (ephrin A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 52.5), lung adult (RPKM 50.2) and 20 other tissues See more
Orthologs
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Genomic context

See Efna1 in Genome Data Viewer
Location:
3 F1; 3 39.04 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89179037..89188258, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89271730..89280951, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene dolichyl-phosphate mannosyltransferase polypeptide 3 Neighboring gene solute carrier family 50 (sugar transporter), member 1 Neighboring gene VISTA enhancer mm1415 Neighboring gene predicted gene, 33845 Neighboring gene predicted gene, 34014 Neighboring gene ephrin A3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ephrin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in aortic valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in endocardial cushion to mesenchymal transition involved in heart valve formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in mitral valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of dendritic spine morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of proteolysis involved in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of thymocyte apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within notochord formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ephrin-A1
Names
EPH-related receptor tyrosine kinase ligand 1
immediate early response protein B61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162425.1NP_001155897.1  ephrin-A1 isoform 2

    See identical proteins and their annotated locations for NP_001155897.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC132327, AK079266
    Consensus CDS
    CCDS50961.1
    UniProtKB/TrEMBL
    D3YTT5
    Related
    ENSMUSP00000112904.2, ENSMUST00000118587.8
    Conserved Domains (1) summary
    cl19115
    Location:184
    Cupredoxin; Cupredoxin superfamily
  2. NM_010107.4NP_034237.3  ephrin-A1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034237.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC132327, AK009144, CN696019
    Consensus CDS
    CCDS17501.1
    UniProtKB/Swiss-Prot
    P52793, P97331
    UniProtKB/TrEMBL
    Q9D7K8
    Related
    ENSMUSP00000029566.3, ENSMUST00000029566.9
    Conserved Domains (1) summary
    cd10425
    Location:19147
    Ephrin-A_Ectodomain; Ectodomain of Ephrin A

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89179037..89188258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)