Efna1 ephrin A1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Efna1provided by MGI
Official Full Name: ephrin A1provided by MGI
Primary source: MGI:MGI:103236
See related: Ensembl:ENSMUSG00000027954 AllianceGenome:MGI:103236
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B61; Efl1; Epl1; Eplg1; Lerk1
Summary: Enables ephrin receptor binding activity. Involved in several processes, including ephrin receptor signaling pathway; heart valve morphogenesis; and negative regulation of dendritic spine morphogenesis. Acts upstream of or within several processes, including negative regulation of thymocyte apoptotic process; nervous system development; and regulation of MAPK cascade. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to human EFNA1 (ephrin A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in colon adult (RPKM 52.5), lung adult (RPKM 50.2) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.04 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (89179037..89188258, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (89271730..89280951, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analysis of ADAM12-Mediated Ephrin-A1 Cleavage and Its Biological Functions.
Title: Analysis of ADAM12-Mediated Ephrin-A1 Cleavage and Its Biological Functions.
By using MALDI-MSI, this study simultaneously shows the distribution and spatial localization of ephrin A1, as well as additional cardiac proteins, thus offering valuable information for the elucidation of molecular partners, mediators, and targets of ephrin A1 action in cardiac muscle.
Title: Anatomical-Molecular Distribution of EphrinA1 in Infarcted Mouse Heart Using MALDI Mass Spectrometry Imaging.
EphA2 mAb treatment could partially inhibit LPSinduced inactivation of EphBEphrin B3 signalling, while Ephrin B3 overexpression could abrogate LPSinduced activation of EphA2Ephrin A1 signalling. EphB1/Ephrin B3 signalling may antagonise the EphA2/Ephrin A1dependent pathway following LPS treatment.
Title: Eph/ephrin signalling serves a bidirectional role in lipopolysaccharide‑induced intestinal injury.
Collectively, these data suggest that ATRA attenuates bleomycin-induced pulmonary fibrosis by regulating EphA2-EphrinA1 and PI3K-Akt signaling.
Title: All-trans retinoic acid attenuates bleomycin-induced pulmonary fibrosis via downregulating EphA2-EphrinA1 signaling.
Lipopolysaccharide exposure significantly up-regulated EphA2 and EphrinA1 expression.
Title: Inhibition of EphA2/EphrinA1 signal attenuates lipopolysaccharide-induced lung injury.
Activation of EphA1-Epha receptor axis attenuates diabetic nephropathy in mice.
Title: Activation of EphA1-Epha receptor axis attenuates diabetic nephropathy in mice.
Following ephrin-A1 stimulation, truncated EphA2 did not detectably interfere with the phosphorylation of endogenous EphA2, and it potentiated cell adhesion possibly through modulation of integrin avidity.
Title: Truncated EphA2 likely potentiates cell adhesion via integrins as well as infiltration and/or lodgment of a monocyte/macrophage cell line in the red pulp and marginal zone of the mouse spleen, where ephrin-A1 is prominently expressed in the vasculature.
ADAM12 enhanced ephrin-A1 cleavage in response to transforming growth factor-betra1 in primary tumors.
Title: ADAM12-cleaved ephrin-A1 contributes to lung metastasis.
S100A8 and ephrin-A1 contribute to lung metastasis.
Title: Ephrin-A1 expression induced by S100A8 is mediated by the toll-like receptor 4.
We used in utero electroporation-mediated EphA7 overexpression in developing somatosensory corticothalamic axons to dissect EphA7/ephrin-A-dependent mechanisms involved in regulating both initial targeting and postnatal growth of the CT projections.
Title: Role of EphA/ephrin--a signaling in the development of topographic maps in mouse corticothalamic projections.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Efna1 (e-PCR), detects polymorphism
- UniSTS:261205

NoName (e-PCR)
- UniSTS:548472

AI325262 (e-PCR)
- UniSTS:159136

Efna1 (e-PCR), detects polymorphism
- UniSTS:546750

Efna1 (e-PCR), detects polymorphism
- UniSTS:266978

Efna1 (e-PCR), detects polymorphism
- UniSTS:495859

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ephrin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ephrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in aortic valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in endocardial cushion to mesenchymal transition involved in heart valve formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ephrin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ephrin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in mitral valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of dendritic spine morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of thymocyte apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within notochord formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of blood vessel endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IEA Inferred from Electronic Annotation more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ephrin-A1

Names: EPH-related receptor tyrosine kinase ligand 1; immediate early response protein B61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162425.1 → NP_001155897.1 ephrin-A1 isoform 2

See identical proteins and their annotated locations for NP_001155897.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC132327, AK079266

Consensus CDS

CCDS50961.1

UniProtKB/TrEMBL

D3YTT5

Related

ENSMUSP00000112904.2, ENSMUST00000118587.8

Conserved Domains (1) summary

cl19115
Location:1 → 84

Cupredoxin; Cupredoxin superfamily
NM_010107.4 → NP_034237.3 ephrin-A1 isoform 1 precursor

See identical proteins and their annotated locations for NP_034237.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC132327, AK009144, CN696019

Consensus CDS

CCDS17501.1

UniProtKB/Swiss-Prot

P52793, P97331

UniProtKB/TrEMBL

Q9D7K8

Related

ENSMUSP00000029566.3, ENSMUST00000029566.9

Conserved Domains (1) summary

cd10425
Location:19 → 147

Ephrin-A_Ectodomain; Ectodomain of Ephrin A