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Eef1a1 eukaryotic translation elongation factor 1 alpha 1 [ Mus musculus (house mouse) ]

Gene ID: 13627, updated on 8-Jan-2023

Summary

Official Symbol
Eef1a1provided by MGI
Official Full Name
eukaryotic translation elongation factor 1 alpha 1provided by MGI
Primary source
MGI:MGI:1096881
See related
Ensembl:ENSMUSG00000037742 AllianceGenome:MGI:1096881
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables calmodulin binding activity. Predicted to be involved in several processes, including cellular response to epidermal growth factor stimulus; negative regulation of reactive oxygen species biosynthetic process; and regulation of D-erythro-sphingosine kinase activity. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human EEF1A1 (eukaryotic translation elongation factor 1 alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 2786.6), bladder adult (RPKM 2579.7) and 28 other tissues See more
Orthologs
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Genomic context

See Eef1a1 in Genome Data Viewer
Location:
9; 9 E1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (78385735..78389006, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (78478453..78481724, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene cyclic GMP-AMP synthase Neighboring gene mitochondrial tRNA translation optimization 1 Neighboring gene predicted gene, 53210 Neighboring gene solute carrier family 17 (anion/sugar transporter), member 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC7551, MGC8115, MGC8209, MGC18758, MGC27859, MGC102592, MGC103271, MGC118397

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heterocyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation by host of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of D-erythro-sphingosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in myelin sheath HDA PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
elongation factor 1-alpha 1
Names
EF-1-alpha-1
EF-Tu
eEF1A-1
elongation factor 1 A-1
elongation factor Tu
eukaryotic elongation factor 1 A-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010106.2NP_034236.2  elongation factor 1-alpha 1

    See identical proteins and their annotated locations for NP_034236.2

    Status: VALIDATED

    Source sequence(s)
    AC158987
    Consensus CDS
    CCDS40703.1
    UniProtKB/Swiss-Prot
    P10126, Q99KU5
    UniProtKB/TrEMBL
    Q58E64
    Related
    ENSMUSP00000042457.9, ENSMUST00000042235.15
    Conserved Domains (1) summary
    PTZ00141
    Location:1460
    PTZ00141; elongation factor 1- alpha; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    78385735..78389006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)