U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Eed embryonic ectoderm development [ Mus musculus (house mouse) ]

Gene ID: 13626, updated on 14-May-2024

Summary

Official Symbol
Eedprovided by MGI
Official Full Name
embryonic ectoderm developmentprovided by MGI
Primary source
MGI:MGI:95286
See related
Ensembl:ENSMUSG00000030619 AllianceGenome:MGI:95286
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
lusk; l7Rn5; l(7)5Rn
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of adaxial/abaxial pattern formation; and regulation of gene expression. Located in pronucleus and sex chromatin. Part of ESC/E(Z) complex and chromatin silencing complex. Is expressed in several structures, including branchial arch; early embryo; extraembryonic component; genitourinary system; and nervous system. Orthologous to human EED (embryonic ectoderm development). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 15.5), liver E14 (RPKM 11.6) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Eed in Genome Data Viewer
Location:
7 D3; 7 50.42 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (89603862..89630184, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (89954654..89980976, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 81 Neighboring gene heat shock protein nuclear import factor Neighboring gene STARR-positive B cell enhancer ABC_E2241 Neighboring gene STARR-seq mESC enhancer starr_19498 Neighboring gene STARR-seq mESC enhancer starr_19499 Neighboring gene STARR-seq mESC enhancer starr_19500 Neighboring gene STARR-positive B cell enhancer ABC_E4947 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:97129229-97129338 Neighboring gene Eed upstream regulatory region Neighboring gene STARR-seq mESC enhancer starr_19501 Neighboring gene STARR-seq mESC enhancer starr_19504 Neighboring gene RIKEN cDNA E230029C05 gene Neighboring gene predicted gene, 32164 Neighboring gene basic transcription factor 3, pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
 
enables histone methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sphingomyelin phosphodiesterase activator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in facultative heterochromatin formation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within genomic imprinting IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of amide metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of cellular metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of adaxial/abaxial pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of membrane lipid metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
part_of ESC/E(Z) complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ESC/E(Z) complex ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin silencing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in pronucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of sex chromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polycomb protein EED
Names
lethal, Chr 7, Rinchik 5

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021876.3NP_068676.1  polycomb protein EED

    See identical proteins and their annotated locations for NP_068676.1

    Status: VALIDATED

    Source sequence(s)
    AK131976, BQ899891, CJ200028, U97675
    Consensus CDS
    CCDS40016.1
    UniProtKB/Swiss-Prot
    P97462, Q921E6
    UniProtKB/TrEMBL
    A0A5F8MPX8
    Related
    ENSMUSP00000159149.2, ENSMUST00000238981.2
    Conserved Domains (2) summary
    sd00039
    Location:96140
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:150438
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    89603862..89630184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)