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TMEM139 transmembrane protein 139 [ Homo sapiens (human) ]

Gene ID: 135932, updated on 23-Nov-2021

Summary

Official Symbol
TMEM139provided by HGNC
Official Full Name
transmembrane protein 139provided by HGNC
Primary source
HGNC:HGNC:22058
See related
Ensembl:ENSG00000178826 MIM:616524
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in kidney (RPKM 17.4), duodenum (RPKM 16.7) and 15 other tissues See more
Orthologs
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Genomic context

See TMEM139 in Genome Data Viewer
Location:
7q34
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (143284899..143288049)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (142981992..142985142)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375546 Neighboring gene TMEM139 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7901 Neighboring gene glutathione S-transferase kappa 1 Neighboring gene RNA, 7SL, cytoplasmic 535, pseudogene Neighboring gene caspase 2 Neighboring gene RNA, 7SL, cytoplasmic 481, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CASP2

Homology

Clone Names

  • FLJ90586

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242773.2NP_001229702.1  transmembrane protein 139 precursor

    See identical proteins and their annotated locations for NP_001229702.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 8, and 9 encode the same protein.
    Source sequence(s)
    AK315170, BC035517, CB241413, HY180523
    Consensus CDS
    CCDS5878.1
    UniProtKB/Swiss-Prot
    Q8IV31
    Related
    ENSP00000386335.1, ENST00000409244.5
  2. NM_001242774.3NP_001229703.1  transmembrane protein 139 precursor

    See identical proteins and their annotated locations for NP_001229703.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 8, and 9 encode the same protein.
    Source sequence(s)
    AC073342, AK172816, BC035517
    Consensus CDS
    CCDS5878.1
    UniProtKB/Swiss-Prot
    Q8IV31
    Related
    ENSP00000386564.1, ENST00000410004.1
  3. NM_001242775.3NP_001229704.1  transmembrane protein 139 precursor

    See identical proteins and their annotated locations for NP_001229704.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 8, and 9 encode the same protein.
    Source sequence(s)
    BC035517, DA626625, HY180523
    Consensus CDS
    CCDS5878.1
    UniProtKB/Swiss-Prot
    Q8IV31
  4. NM_001282876.2NP_001269805.1  transmembrane protein 139 precursor

    See identical proteins and their annotated locations for NP_001269805.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 8, and 9 encode the same protein.
    Source sequence(s)
    BC035517, DA628164
    Consensus CDS
    CCDS5878.1
    UniProtKB/Swiss-Prot
    Q8IV31
    Related
    ENSP00000352284.3, ENST00000359333.8
  5. NM_001282877.1NP_001269806.1  transmembrane protein 139 precursor

    See identical proteins and their annotated locations for NP_001269806.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 8, and 9 encode the same protein.
    Source sequence(s)
    BC035517, CB241413, HY180523
    Consensus CDS
    CCDS5878.1
    UniProtKB/Swiss-Prot
    Q8IV31
  6. NM_153345.3NP_699176.1  transmembrane protein 139 precursor

    See identical proteins and their annotated locations for NP_699176.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 2, 3, 4, 8, and 9 encode the same protein.
    Source sequence(s)
    AK075067, BC035517, CB241413, HY180523
    Consensus CDS
    CCDS5878.1
    UniProtKB/Swiss-Prot
    Q8IV31
    Related
    ENSP00000387044.1, ENST00000409541.5

RNA

  1. NR_040003.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    BC035517, BE018738, DA839855
    Related
    ENST00000471161.1
  2. NR_104250.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    BC035517, CB142336, CB241413, HY180523
  3. NR_104251.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    BC035517, CB241413, DT220400, HY180523
  4. NR_104252.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    BC035517, BF036500, CB241413, DB222115, HY180523
  5. NR_104253.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    BC035517, BI761527, CB156055, HY180523
  6. NR_104254.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    BC035517, BE562464, HY180523, R69052

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    143284899..143288049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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