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CPA3 carboxypeptidase A3 [ Homo sapiens (human) ]

Gene ID: 1359, updated on 8-Jul-2021

Summary

Official Symbol
CPA3provided by HGNC
Official Full Name
carboxypeptidase A3provided by HGNC
Primary source
HGNC:HGNC:2298
See related
Ensembl:ENSG00000163751 MIM:114851
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MC-CPA
Summary
This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein is proteolytically processed to generate a mature protease that is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated peptides. Expression of this gene may be elevated in human asthma patients. [provided by RefSeq, Nov 2015]
Expression
Biased expression in gall bladder (RPKM 74.3), lung (RPKM 46.6) and 11 other tissues See more
Orthologs
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Genomic context

See CPA3 in Genome Data Viewer
Location:
3q24
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (148865296..148897203)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (148583083..148614990)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene high mobility group box 1 pseudogene 30 Neighboring gene carboxypeptidase B1 Neighboring gene uncharacterized LOC107986045 Neighboring gene ubiquilin 4 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metallocarboxypeptidase activity EXP
Inferred from Experiment
more info
PubMed 
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metallocarboxypeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables metallocarboxypeptidase activity TAS
Traceable Author Statement
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in angiotensin maturation TAS
Traceable Author Statement
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
mast cell carboxypeptidase A
Names
carboxypeptidase A3 (mast cell)
tissue carboxypeptidase A
NP_001861.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001870.4NP_001861.2  mast cell carboxypeptidase A preproprotein

    See identical proteins and their annotated locations for NP_001861.2

    Status: REVIEWED

    Source sequence(s)
    AC092979, BC012613, BG501260, BX105358, DR005288, M27717
    Consensus CDS
    CCDS3138.1
    UniProtKB/Swiss-Prot
    P15088
    Related
    ENSP00000296046.3, ENST00000296046.4
    Conserved Domains (2) summary
    cd03871
    Location:114413
    M14_CPB; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B subgroup
    pfam02244
    Location:28102
    Propep_M14; Carboxypeptidase activation peptide

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    148865296..148897203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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