Format

Send to:

Choose Destination

CPA3 carboxypeptidase A3 [ Homo sapiens (human) ]

Gene ID: 1359, updated on 12-Oct-2019

Summary

Official Symbol
CPA3provided by HGNC
Official Full Name
carboxypeptidase A3provided by HGNC
Primary source
HGNC:HGNC:2298
See related
Ensembl:ENSG00000163751 MIM:114851
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MC-CPA
Summary
This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein is proteolytically processed to generate a mature protease that is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated peptides. Expression of this gene may be elevated in human asthma patients. [provided by RefSeq, Nov 2015]
Expression
Biased expression in gall bladder (RPKM 74.3), lung (RPKM 46.6) and 11 other tissues See more
Orthologs

Genomic context

See CPA3 in Genome Data Viewer
Location:
3q24
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (148865296..148897203)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (148583043..148614874)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene high mobility group box 1 pseudogene 30 Neighboring gene carboxypeptidase B1 Neighboring gene uncharacterized LOC107986045 Neighboring gene ubiquilin 4 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystem (from REACTOME)
    Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystemAngiotensinogen, a prohormone, is synthesized and secreted mainly by the liver but also from other tissues (reviewed in Fyhrquist and Saijonmaa 2008, Cat and Touyz 2011). Renin, an aspartyl protease ...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Pancreatic secretion, organism-specific biosystem (from KEGG)
    Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Pancreatic secretion, conserved biosystem (from KEGG)
    Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
    Peptide hormone metabolism, organism-specific biosystemPeptide hormones are cleaved from larger precursors in the secretory system (endoplasmic reticulum, Golgi apparatus, secretory granules) of the cell. After secretion peptide hormones are modified and...
  • Protein digestion and absorption, organism-specific biosystem (from KEGG)
    Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
  • Protein digestion and absorption, conserved biosystem (from KEGG)
    Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
  • Renin-angiotensin system, organism-specific biosystem (from KEGG)
    Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
  • Renin-angiotensin system, conserved biosystem (from KEGG)
    Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metallocarboxypeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
metallocarboxypeptidase activity TAS
Traceable Author Statement
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
angiotensin maturation TAS
Traceable Author Statement
more info
 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
extracellular region HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
secretory granule NAS
Non-traceable Author Statement
more info
PubMed 
transport vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mast cell carboxypeptidase A
Names
carboxypeptidase A3 (mast cell)
tissue carboxypeptidase A
NP_001861.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001870.4NP_001861.2  mast cell carboxypeptidase A preproprotein

    See identical proteins and their annotated locations for NP_001861.2

    Status: REVIEWED

    Source sequence(s)
    AC092979, BC012613, BG501260, BX105358, DR005288, M27717
    Consensus CDS
    CCDS3138.1
    UniProtKB/Swiss-Prot
    P15088
    Related
    ENSP00000296046.3, ENST00000296046.4
    Conserved Domains (2) summary
    cd03871
    Location:114413
    M14_CPB; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B subgroup
    pfam02244
    Location:28102
    Propep_M14; Carboxypeptidase activation peptide

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    148865296..148897203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center