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TMEM270 transmembrane protein 270 [ Homo sapiens (human) ]

Gene ID: 135886, updated on 25-Jan-2022

Summary

Official Symbol
TMEM270provided by HGNC
Official Full Name
transmembrane protein 270provided by HGNC
Primary source
HGNC:HGNC:23018
See related
Ensembl:ENSG00000175877 MIM:612547; AllianceGenome:HGNC:23018
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WBSCR28
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Restricted expression toward testis (RPKM 15.2) See more
Orthologs
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Genomic context

See TMEM270 in Genome Data Viewer
Location:
7q11.23
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (73860848..73865892)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (73275489..73280220)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene methyltransferase like 27 Neighboring gene claudin 4 Neighboring gene Sharpr-MPRA regulatory region 8209 Neighboring gene Sharpr-MPRA regulatory region 9451

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26719

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 270
Names
Williams-Beuren syndrome chromosome region 28
Williams-Beuren syndrome critical region 28
williams-Beuren syndrome chromosomal region 28 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182504.4NP_872310.2  transmembrane protein 270

    See identical proteins and their annotated locations for NP_872310.2

    Status: VALIDATED

    Source sequence(s)
    AC093168, AY372053
    Consensus CDS
    CCDS43597.1
    UniProtKB/Swiss-Prot
    Q6UE05
    Related
    ENSP00000316775.2, ENST00000320531.3
    Conserved Domains (1) summary
    pfam15164
    Location:1265
    WBS28; Williams-Beuren syndrome chromosomal region 28 protein homologue

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    73860848..73865892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011741.1XP_016867230.1  transmembrane protein 270 isoform X1

    UniProtKB/Swiss-Prot
    Q6UE05
    Conserved Domains (1) summary
    pfam15164
    Location:1168
    WBS28; Williams-Beuren syndrome chromosomal region 28 protein homologue
  2. XM_011515785.2XP_011514087.1  transmembrane protein 270 isoform X1

    See identical proteins and their annotated locations for XP_011514087.1

    UniProtKB/Swiss-Prot
    Q6UE05
    Conserved Domains (1) summary
    pfam15164
    Location:1168
    WBS28; Williams-Beuren syndrome chromosomal region 28 protein homologue
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