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Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a [ Mus musculus (house mouse) ]

Gene ID: 13548, updated on 9-Mar-2023

Summary

Official Symbol
Dyrk1aprovided by MGI
Official Full Name
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1aprovided by MGI
Primary source
MGI:MGI:1330299
See related
Ensembl:ENSMUSG00000022897 AllianceGenome:MGI:1330299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mmb; Dyrk; Mnbh; Mp86; Gm10783; D16Ertd272e; D16Ertd493e; 2310043O08Rik
Summary
Enables several functions, including identical protein binding activity; protein self-association; and tau protein binding activity. Involved in several processes, including negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of microtubule polymerization; and protein phosphorylation. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome and peptidyl-tyrosine phosphorylation. Located in several cellular components, including axon; cytoskeleton; and dendrite. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Used to study Down syndrome. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant non-syndromic intellectual disability 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 12.2), whole brain E14.5 (RPKM 10.0) and 28 other tissues See more
Orthologs
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Genomic context

See Dyrk1a in Genome Data Viewer
Location:
16 C4; 16 55.3 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (94370637..94496378)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (94569947..94695519)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 3 Neighboring gene predicted gene, 23692 Neighboring gene predicted gene, 31323 Neighboring gene VPS26 endosomal protein sorting factor C Neighboring gene predicted gene, 53922 Neighboring gene predicted gene, 41504 Neighboring gene predicted gene, 41507

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC150253, MGC150254

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II CTD heptapeptide repeat kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables histone H3T45 kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein self-association IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables tau protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA methylation-dependent heterochromatin formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with neurofilament ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity tyrosine-phosphorylation-regulated kinase 1A
Names
dual specificity YAK1-related kinase
protein kinase minibrain homolog
NP_001106860.1
NP_001334660.1
NP_031916.1
XP_011244396.1
XP_011244397.1
XP_011244398.1
XP_011244400.1
XP_011244401.1
XP_036015668.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113389.1NP_001106860.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1

    See identical proteins and their annotated locations for NP_001106860.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' non-coding exon, therefore, has a different 5' UTR compared to transcript variant 1. Transcript variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK052390, AK163136, BC129888, CB526389, CX566606
    Consensus CDS
    CCDS28350.1
    UniProtKB/Swiss-Prot
    Q61214
    UniProtKB/TrEMBL
    A0A6P7Q6P7, A0A8C6GVY3, A1L341, A9C475, Q8C774
    Related
    ENSMUSP00000023614.5, ENSMUST00000023614.5
    Conserved Domains (1) summary
    cd14226
    Location:148484
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
  2. NM_001347731.2NP_001334660.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC165271, CT030190
    UniProtKB/TrEMBL
    A0A6P7QIU0, A1L341
    Conserved Domains (1) summary
    cd14226
    Location:139475
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
  3. NM_001402791.1NP_001389720.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC165271, CT030190
    UniProtKB/Swiss-Prot
    Q61214
    UniProtKB/TrEMBL
    A0A6P7Q6P7, A0A8C6GVY3, A9C475
  4. NM_001402792.1NP_001389721.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC165271, CT030190
  5. NM_001402793.1NP_001389722.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC165271, CT030190
    UniProtKB/TrEMBL
    A0A6P7QNX3, F6U6X3
  6. NM_007890.2NP_031916.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1

    See identical proteins and their annotated locations for NP_031916.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Transcript variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK052390, AK163136, BC129888, BF462682, CD540384, CX566606
    Consensus CDS
    CCDS28350.1
    UniProtKB/Swiss-Prot
    Q61214
    UniProtKB/TrEMBL
    A0A6P7Q6P7, A0A8C6GVY3, A1L341, A9C475, Q8C774
    Related
    ENSMUSP00000113660.2, ENSMUST00000119878.8
    Conserved Domains (1) summary
    cd14226
    Location:148484
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    94370637..94496378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246098.4XP_011244400.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X3

    Conserved Domains (1) summary
    cd14226
    Location:119455
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
  2. XM_011246099.4XP_011244401.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X4

    Related
    ENSMUSP00000112853.3, ENSMUST00000122284.9
    Conserved Domains (1) summary
    cd14226
    Location:110446
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
  3. XM_011246096.4XP_011244398.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2

    UniProtKB/TrEMBL
    A1L341
    Conserved Domains (1) summary
    cd14226
    Location:139475
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
  4. XM_011246094.3XP_011244396.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

    UniProtKB/Swiss-Prot
    Q61214
    UniProtKB/TrEMBL
    A9C475
    Conserved Domains (1) summary
    cd14226
    Location:148484
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
  5. XM_036159775.1XP_036015668.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2

    UniProtKB/TrEMBL
    A0A6P7QIU0, A1L341
    Conserved Domains (1) summary
    cd14226
    Location:139475
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
  6. XM_011246095.4XP_011244397.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

    See identical proteins and their annotated locations for XP_011244397.1

    UniProtKB/Swiss-Prot
    Q61214
    UniProtKB/TrEMBL
    A0A6P7Q6P7, A0A8C6GVY3, A9C475
    Conserved Domains (1) summary
    cd14226
    Location:148484
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1