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Dvl1 dishevelled segment polarity protein 1 [ Mus musculus (house mouse) ]

Gene ID: 13542, updated on 22-Nov-2020

Summary

Official Symbol
Dvl1provided by MGI
Official Full Name
dishevelled segment polarity protein 1provided by MGI
Primary source
MGI:MGI:94941
See related
Ensembl:ENSMUSG00000029071
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dvl; mKIAA4029
Summary
The protein encoded by this gene is a member of the Dishevelled family of proteins. These proteins have an N-terminal Dishevelled/Axin domain, a Dishevelled, EGL-10, Plextrin domain, a central PDZ domain, and a C-terminal domain of approximately 200 amino acids. They regulate both canonical and non-canonical Wnt signaling as well as planar cell polarity pathways. Mice deficient for this gene are viable and fertile but display reduced social interaction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Ubiquitous expression in ovary adult (RPKM 66.4), duodenum adult (RPKM 56.2) and 28 other tissues See more
Orthologs

Genomic context

See Dvl1 in Genome Data Viewer
Location:
4 E2; 4 87.61 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155931829..155943760)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155847402..155859303)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (155221521..155233412)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene aurora kinase A interacting protein 1 Neighboring gene matrix-remodelling associated 8 Neighboring gene taste receptor, type 1, member 3 Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene integrator complex subunit 11 Neighboring gene pseudouridylate synthase-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4029

Gene Ontology Provided by MGI

Function Evidence Code Pubs
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
frizzled binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Wnt signaling pathway, planar cell polarity pathway IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway, planar cell polarity pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
Wnt signaling pathway, planar cell polarity pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Wnt signaling pathway, planar cell polarity pathway ISO
Inferred from Sequence Orthology
more info
 
axon extension IDA
Inferred from Direct Assay
more info
PubMed 
axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cochlea morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
collateral sprouting IDA
Inferred from Direct Assay
more info
PubMed 
convergent extension involved in neural plate elongation IGI
Inferred from Genetic Interaction
more info
PubMed 
convergent extension involved in organogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
convergent extension involved in organogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasmic microtubule organization IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic microtubule organization IGI
Inferred from Genetic Interaction
more info
PubMed 
dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
neuromuscular junction development IGI
Inferred from Genetic Interaction
more info
PubMed 
neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
planar cell polarity pathway involved in neural tube closure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
planar cell polarity pathway involved in neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection arborization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
postsynapse organization IDA
Inferred from Direct Assay
more info
PubMed 
postsynapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
prepulse inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
presynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
presynapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to microtubule IGI
Inferred from Genetic Interaction
more info
PubMed 
protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
protein stabilization IGI
Inferred from Genetic Interaction
more info
PubMed 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
receptor clustering IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cellular protein localization ISO
Inferred from Sequence Orthology
more info
 
regulation of neurotransmitter levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic vesicle exocytosis IPI
Inferred from Physical Interaction
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
skeletal muscle acetylcholine-gated channel clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
synapse organization IGI
Inferred from Genetic Interaction
more info
PubMed 
synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
Schaffer collateral - CA1 synapse IPI
Inferred from Physical Interaction
more info
PubMed 
Wnt signalosome IDA
Inferred from Direct Assay
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
growth cone ISO
Inferred from Sequence Orthology
more info
 
lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
presynapse IDA
Inferred from Direct Assay
more info
PubMed 
presynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
segment polarity protein dishevelled homolog DVL-1
Names
DSH homolog 1
dishevelled, dsh homolog 1
dishevelled-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356381.1NP_001343310.1  segment polarity protein dishevelled homolog DVL-1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL670236, BC088987, U10115
    Related
    ENSMUST00000143457.7
    Conserved Domains (5) summary
    smart00021
    Location:185
    DAX; Domain present in Dishevelled and axin
    cd04438
    Location:417499
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam00595
    Location:251336
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02377
    Location:90247
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:503571
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
  2. NM_010091.5NP_034221.3  segment polarity protein dishevelled homolog DVL-1 isoform 1

    See identical proteins and their annotated locations for NP_034221.3

    Status: REVIEWED

    Source sequence(s)
    AL670236, BC088987, U10115
    Consensus CDS
    CCDS19045.1
    UniProtKB/Swiss-Prot
    P51141
    Related
    ENSMUSP00000030948.9, ENSMUST00000030948.15
    Conserved Domains (5) summary
    smart00021
    Location:185
    DAX; Domain present in Dishevelled and axin
    cd04438
    Location:417499
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam00595
    Location:251336
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02377
    Location:90247
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:503685
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    155931829..155943760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538523.4XP_006538586.1  segment polarity protein dishevelled homolog DVL-1 isoform X6

    Conserved Domains (4) summary
    smart00021
    Location:185
    DAX; Domain present in Dishevelled and axin
    cd04438
    Location:431513
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam00595
    Location:251336
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02377
    Location:90247
    Dishevelled; Dishevelled specific domain
  2. XM_006538518.4XP_006538581.1  segment polarity protein dishevelled homolog DVL-1 isoform X1

    Conserved Domains (5) summary
    smart00021
    Location:185
    DAX; Domain present in Dishevelled and axin
    cd04438
    Location:431513
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam00595
    Location:251336
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02377
    Location:90247
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:517699
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
  3. XM_006538519.4XP_006538582.1  segment polarity protein dishevelled homolog DVL-1 isoform X2

    Conserved Domains (5) summary
    smart00021
    Location:185
    DAX; Domain present in Dishevelled and axin
    cd04438
    Location:406488
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam00595
    Location:251336
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02377
    Location:90247
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:492674
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
  4. XM_006538520.5XP_006538583.1  segment polarity protein dishevelled homolog DVL-1 isoform X3

    Conserved Domains (5) summary
    smart00021
    Location:185
    DAX; Domain present in Dishevelled and axin
    cd04438
    Location:392474
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam00595
    Location:251336
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02377
    Location:90247
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:478660
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
  5. XM_006538521.4XP_006538584.1  segment polarity protein dishevelled homolog DVL-1 isoform X4

    Conserved Domains (5) summary
    smart00021
    Location:185
    DAX; Domain present in Dishevelled and axin
    cd04438
    Location:366448
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam00595
    Location:251336
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02377
    Location:90247
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:452634
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
  6. XM_006538522.5XP_006538585.1  segment polarity protein dishevelled homolog DVL-1 isoform X5

    Conserved Domains (4) summary
    smart00021
    Location:185
    DAX; Domain present in Dishevelled and axin
    cd04438
    Location:431513
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam00595
    Location:251336
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02377
    Location:90247
    Dishevelled; Dishevelled specific domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001302342.1: Suppressed sequence

    Description
    NM_001302342.1: This RefSeq was removed because currently there is insufficient support for the transcript.
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