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B3GAT2 beta-1,3-glucuronyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 135152, updated on 5-Mar-2024


Official Symbol
B3GAT2provided by HGNC
Official Full Name
beta-1,3-glucuronyltransferase 2provided by HGNC
Primary source
See related
Ensembl:ENSG00000112309 MIM:607497; AllianceGenome:HGNC:922
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
The product of this gene is a transmembrane protein belonging to the glucuronyltransferase family, and catalyzes the transfer of a beta-1,3 linked glucuronic acid to a terminal galactose in different glycoproteins or glycolipids containing a Gal-beta-1-4GlcNAc or Gal-beta-1-3GlcNAc residue. The encoded protein is involved in the synthesis of the human natural killer-1 (HNK-1) carbohydrate epitope, a sulfated trisaccharide implicated in cellular migration and adhesion in the nervous system. [provided by RefSeq, Jul 2008]
Ubiquitous expression in brain (RPKM 8.3), duodenum (RPKM 3.6) and 25 other tissues See more
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Genomic context

See B3GAT2 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (70856679..70957060, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (72037217..72137607, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (71566382..71666763, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 192 pseudogene Neighboring gene small ArfGAP 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24734 Neighboring gene NADH:ubiquinone oxidoreductase subunit AB1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:71481211-71481711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17323 Neighboring gene uncharacterized LOC105377850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:71666023-71666538 Neighboring gene uncharacterized LOC124901229 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:71708165-71708862 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:71719574-71720074 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:71737398-71738597 Neighboring gene beclin 1 pseudogene 2 Neighboring gene small nucleolar RNA U3

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


EBI GWAS Catalog

Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Clone Names

  • KIAA1963, MGC138535

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
involved_in carbohydrate biosynthetic process IEA
Inferred from Electronic Annotation
more info
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
involved_in chondroitin sulfate proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
located_in Golgi membrane TAS
Traceable Author Statement
more info

General protein information

Preferred Names
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
UDP-glucuronosyltransferase S
UDP-glucuronyltransferase S
glucuronosyltransferase S
uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080742.3NP_542780.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 precursor

    See identical proteins and their annotated locations for NP_542780.1

    Status: REVIEWED

    Source sequence(s)
    AB075843, AL121961, DA782678
    Consensus CDS
    Q5JS09, Q8TF38, Q96NK4, Q9NPZ5
    ENSP00000230053.6, ENST00000230053.11
    Conserved Domains (1) summary
    GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    70856679..70957060 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418209.1XP_047274165.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 isoform X1

Alternate T2T-CHM13v2.0


  1. NC_060930.1 Alternate T2T-CHM13v2.0

    72037217..72137607 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354301.1XP_054210276.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 isoform X1