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Dsg1a desmoglein 1 alpha [ Mus musculus (house mouse) ]

Gene ID: 13510, updated on 8-Feb-2024

Summary

Official Symbol
Dsg1aprovided by MGI
Official Full Name
desmoglein 1 alphaprovided by MGI
Primary source
MGI:MGI:94930
See related
Ensembl:ENSMUSG00000069441 AllianceGenome:MGI:94930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DG1; DGI; Dsg1; dsg1-alpha
Summary
This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Jan 2016]
Expression
Biased expression in testis adult (RPKM 8.1), limb E14.5 (RPKM 2.2) and 3 other tissues See more
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Genomic context

See Dsg1a in Genome Data Viewer
Location:
18 A2; 18 11.29 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (20443982..20476407)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (20310873..20343353)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene desmocollin 1 Neighboring gene STARR-seq mESC enhancer starr_43958 Neighboring gene STARR-seq mESC enhancer starr_43959 Neighboring gene STARR-seq mESC enhancer starr_43960 Neighboring gene desmoglein 1 gamma Neighboring gene STARR-seq mESC enhancer starr_43962 Neighboring gene predicted gene, 31237 Neighboring gene desmoglein 1 beta Neighboring gene STARR-seq mESC enhancer starr_43965 Neighboring gene desmoglein 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables gamma-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables gamma-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in desmosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in desmosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in desmosome ISO
Inferred from Sequence Orthology
more info
 
located_in desmosome TAS
Traceable Author Statement
more info
PubMed 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
desmoglein-1-alpha
Names
desmosomal glycoprotein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010079.3NP_034209.2  desmoglein-1-alpha preproprotein

    See identical proteins and their annotated locations for NP_034209.2

    Status: VALIDATED

    Source sequence(s)
    AC108943
    Consensus CDS
    CCDS50231.1
    UniProtKB/Swiss-Prot
    A8WFQ4, Q61495, Q8CE03
    Related
    ENSMUSP00000076393.4, ENSMUST00000077146.4
    Conserved Domains (3) summary
    cd11304
    Location:165265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:73155
    CA; Cadherin repeats
    pfam01049
    Location:664779
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    20443982..20476407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525597.2XP_006525660.1  desmoglein-1-alpha isoform X1

    Conserved Domains (1) summary
    pfam01049
    Location:198313
    Cadherin_C; Cadherin cytoplasmic region