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Atn1 atrophin 1 [ Mus musculus (house mouse) ]

Gene ID: 13498, updated on 18-Apr-2024

Summary

Official Symbol
Atn1provided by MGI
Official Full Name
atrophin 1provided by MGI
Primary source
MGI:MGI:104725
See related
Ensembl:ENSMUSG00000004263 AllianceGenome:MGI:104725
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atr1; Drpla; atrophin-1
Summary
Enables toxin activity; transcription coactivator activity; and transcription corepressor activity. Involved in cell migration and maintenance of cell polarity. Acts upstream of or within several processes, including determination of adult lifespan; male gonad development; and response to food. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Human ortholog(s) of this gene implicated in dentatorubral-pallidoluysian atrophy and schizophrenia. Orthologous to human ATN1 (atrophin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 42.5), adrenal adult (RPKM 42.5) and 25 other tissues See more
Orthologs
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Genomic context

Location:
6 F2; 6 59.17 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124719507..124733450, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124742544..124756487, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene gene rich cluster, C10 gene Neighboring gene STARR-positive B cell enhancer ABC_E8991 Neighboring gene U7 small nuclear RNA Neighboring gene STARR-seq mESC enhancer starr_17303 Neighboring gene enolase 2, gamma neuronal Neighboring gene leucine rich repeat containing 23

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Grcc10

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables JUN kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
atrophin-1
Names
dentatorubral pallidoluysian atrophy
dentatorubral-pallidoluysian atrophy protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007881.4NP_031907.2  atrophin-1

    See identical proteins and their annotated locations for NP_031907.2

    Status: VALIDATED

    Source sequence(s)
    BC050920, BC053051
    Consensus CDS
    CCDS20526.1
    UniProtKB/Swiss-Prot
    O35126, P70200, Q80YQ0
    Related
    ENSMUSP00000085695.6, ENSMUST00000088357.12
    Conserved Domains (1) summary
    pfam03154
    Location:11174
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    124719507..124733450 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)