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Drd4 dopamine receptor D4 [ Mus musculus (house mouse) ]

Gene ID: 13491, updated on 8-Dec-2022

Summary

Official Symbol
Drd4provided by MGI
Official Full Name
dopamine receptor D4provided by MGI
Primary source
MGI:MGI:94926
See related
Ensembl:ENSMUSG00000025496 AllianceGenome:MGI:94926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D4R; Drd-4
Summary
Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in regulation of circadian rhythm and regulation of postsynaptic neurotransmitter receptor internalization. Acts upstream of or within several processes, including adenylate cyclase-inhibiting dopamine receptor signaling pathway; behavioral response to cocaine; and inhibitory postsynaptic potential. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system gland; integumental system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and dyslexia. Orthologous to human DRD4 (dopamine receptor D4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 6.8), testis adult (RPKM 3.5) and 4 other tissues See more
Orthologs
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Genomic context

See Drd4 in Genome Data Viewer
Location:
7 F5; 7 86.6 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140871887..140876377)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141291974..141296464)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cadherin-related family member 5 Neighboring gene secretin Neighboring gene DEAF1, transcription factor Neighboring gene predicted gene, 53347 Neighboring gene transmembrane protein 80

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables dopamine binding ISO
Inferred from Sequence Orthology
more info
 
enables dopamine neurotransmitter receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go ISO
Inferred from Sequence Orthology
more info
 
enables epinephrine binding ISO
Inferred from Sequence Orthology
more info
 
enables heterocyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables norepinephrine binding ISO
Inferred from Sequence Orthology
more info
 
enables serotonin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within adenylate cyclase-inhibiting dopamine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in arachidonic acid secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in associative learning ISO
Inferred from Sequence Orthology
more info
 
involved_in behavioral fear response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within behavioral response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inhibitory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in olfactory learning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of penile erection ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sodium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in presynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic neurotransmitter receptor internalization EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to amphetamine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to histamine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in short-term memory ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic transmission, dopaminergic ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
D(4) dopamine receptor
Names
d(2C) dopamine receptor
dopamine receptor 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412325.1NP_001399254.1  D(4) dopamine receptor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163434
  2. NM_001412326.1NP_001399255.1  D(4) dopamine receptor isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163434
  3. NM_007878.4NP_031904.1  D(4) dopamine receptor isoform 1

    See identical proteins and their annotated locations for NP_031904.1

    Status: VALIDATED

    Source sequence(s)
    AC163434
    Consensus CDS
    CCDS22007.1
    UniProtKB/Swiss-Prot
    P51436, Q8BXS4
    UniProtKB/TrEMBL
    A0A8C6I837
    Related
    ENSMUSP00000026569.5, ENSMUST00000026569.6
    Conserved Domains (1) summary
    pfam00001
    Location:48368
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140871887..140876377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006536156.5XP_006536219.1  D(4) dopamine receptor isoform X1

    Conserved Domains (2) summary
    cd14964
    Location:2854
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:10341
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_017321972.1XP_017177461.1  D(4) dopamine receptor isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:127
    7tm_GPCRs; TM helix 3 [structural motif]
    cl28897
    Location:1271
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily