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Dpp4 dipeptidylpeptidase 4 [ Mus musculus (house mouse) ]

Gene ID: 13482, updated on 8-Feb-2024

Summary

Official Symbol
Dpp4provided by MGI
Official Full Name
dipeptidylpeptidase 4provided by MGI
Primary source
MGI:MGI:94919
See related
Ensembl:ENSMUSG00000035000 AllianceGenome:MGI:94919
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd26; THAM; Dpp-4
Summary
Predicted to enable several functions, including chemorepellent activity; peptidase activity; and protein homodimerization activity. Acts upstream of or within behavioral fear response; locomotory exploration behavior; and psychomotor behavior. Located in intercellular canaliculus. Is expressed in several structures, including genitourinary system; inner ear; intraembryonic coelom; liver; and primitive heart tube. Used to study Middle East respiratory syndrome. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (dipeptidyl peptidase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 30.2), small intestine adult (RPKM 11.7) and 11 other tissues See more
Orthologs
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Genomic context

See Dpp4 in Genome Data Viewer
Location:
2 C1.3; 2 35.85 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (62160417..62242635, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (62330073..62412315, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04636 Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene Neighboring gene solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 Neighboring gene STARR-seq mESC enhancer starr_04637 Neighboring gene STARR-positive B cell enhancer mm9_chr2:62123780-62124080 Neighboring gene STARR-positive B cell enhancer mm9_chr2:62229877-62230177 Neighboring gene STARR-seq mESC enhancer starr_04638 Neighboring gene STARR-seq mESC enhancer starr_04639 Neighboring gene STARR-positive B cell enhancer ABC_E5925 Neighboring gene STARR-positive B cell enhancer ABC_E8786 Neighboring gene STARR-positive B cell enhancer ABC_E8787 Neighboring gene STARR-seq mESC enhancer starr_04641 Neighboring gene STARR-positive B cell enhancer ABC_E3379 Neighboring gene STARR-positive B cell enhancer ABC_E2037 Neighboring gene STARR-positive B cell enhancer ABC_E5926 Neighboring gene STARR-positive B cell enhancer ABC_E5927 Neighboring gene Gcg promoter region Neighboring gene predicted gene 13561 Neighboring gene glucagon

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables chemorepellent activity ISO
Inferred from Sequence Orthology
more info
 
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dipeptidyl-peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in B-1a B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell costimulation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within locomotory exploration behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell mediated immunity ISO
Inferred from Sequence Orthology
more info
 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within psychomotor behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of T cell mediated immunity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell-cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in intercellular canaliculus IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dipeptidyl peptidase 4
Names
DPP IV
T-cell activation antigen CD26
dipeptidyl peptidase IV
thymocyte-activating molecule
NP_001153015.1
NP_034204.1
XP_006498754.1
XP_006498755.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159543.1NP_001153015.1  dipeptidyl peptidase 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK085370, AK163085, AL928804
    UniProtKB/TrEMBL
    Q3TR43
    Conserved Domains (3) summary
    pfam00930
    Location:102472
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    pfam00326
    Location:553729
    Peptidase_S9; Prolyl oligopeptidase family
    pfam18811
    Location:3656
    DPPIV_rep; Dipeptidyl peptidase IV (DPP IV) low complexity region
  2. NM_010074.3NP_034204.1  dipeptidyl peptidase 4 isoform 1

    See identical proteins and their annotated locations for NP_034204.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK085370, AK163085, AL928804
    Consensus CDS
    CCDS16065.1
    UniProtKB/Swiss-Prot
    P28843, Q3U514
    UniProtKB/TrEMBL
    Q3TR43
    Related
    ENSMUSP00000044050.8, ENSMUST00000047812.8
    Conserved Domains (3) summary
    COG1506
    Location:392758
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    pfam00326
    Location:553757
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:102472
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    62160417..62242635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498691.5XP_006498754.1  dipeptidyl peptidase 4 isoform X2

    UniProtKB/TrEMBL
    Q3TR43
    Conserved Domains (3) summary
    pfam00930
    Location:102472
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    pfam18811
    Location:3756
    DPPIV_rep; Dipeptidyl peptidase IV (DPP IV) low complexity region
    cl21494
    Location:553678
    Abhydrolase; alpha/beta hydrolases
  2. XM_006498692.5XP_006498755.1  dipeptidyl peptidase 4 isoform X1

    UniProtKB/TrEMBL
    Q3TR43
    Conserved Domains (3) summary
    pfam00930
    Location:102472
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    pfam18811
    Location:3756
    DPPIV_rep; Dipeptidyl peptidase IV (DPP IV) low complexity region
    cl21494
    Location:553679
    Abhydrolase; alpha/beta hydrolases