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Dpp4 dipeptidylpeptidase 4 [ Mus musculus (house mouse) ]

Gene ID: 13482, updated on 23-Dec-2018

Summary

Official Symbol
Dpp4provided by MGI
Official Full Name
dipeptidylpeptidase 4provided by MGI
Primary source
MGI:MGI:94919
See related
Ensembl:ENSMUSG00000035000
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd26; THAM; Dpp-4
Expression
Biased expression in large intestine adult (RPKM 30.2), small intestine adult (RPKM 11.7) and 11 other tissues See more
Orthologs

Genomic context

See Dpp4 in Genome Data Viewer
Location:
2 C1.3; 2 35.85 cM
Exon count:
30
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (62330073..62412318, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (62168130..62250288, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene Neighboring gene solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 Neighboring gene predicted gene 13561 Neighboring gene glucagon

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
collagen binding ISO
Inferred from Sequence Orthology
more info
 
dipeptidyl-peptidase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
peptide binding ISO
Inferred from Sequence Orthology
more info
 
protease binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
virus receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
T cell activation ISO
Inferred from Sequence Orthology
more info
 
T cell costimulation ISO
Inferred from Sequence Orthology
more info
 
behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
establishment of localization ISO
Inferred from Sequence Orthology
more info
 
locomotory exploration behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
psychomotor behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of T cell mediated immunity ISO
Inferred from Sequence Orthology
more info
 
regulation of cell-cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intercellular canaliculus IDA
Inferred from Direct Assay
more info
PubMed 
invadopodium membrane ISO
Inferred from Sequence Orthology
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dipeptidyl peptidase 4
Names
DPP IV
T-cell activation antigen CD26
dipeptidyl peptidase IV
thymocyte-activating molecule
NP_001153015.1
NP_034204.1
XP_006498754.1
XP_006498755.1
XP_011237576.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159543.1NP_001153015.1  dipeptidyl peptidase 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK085370, AK163085, AL928804
    UniProtKB/Swiss-Prot
    P28843
    UniProtKB/TrEMBL
    Q3TR43
    Conserved Domains (3) summary
    COG1506
    Location:392729
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    pfam00326
    Location:553729
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:102472
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
  2. NM_010074.3NP_034204.1  dipeptidyl peptidase 4 isoform 1

    See identical proteins and their annotated locations for NP_034204.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK085370, AK163085, AL928804
    Consensus CDS
    CCDS16065.1
    UniProtKB/Swiss-Prot
    P28843
    UniProtKB/TrEMBL
    Q3TR43
    Related
    ENSMUSP00000044050.7, ENSMUST00000047812.7
    Conserved Domains (3) summary
    COG1506
    Location:392758
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    pfam00326
    Location:553757
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:102472
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    62330073..62412318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498691.3XP_006498754.1  dipeptidyl peptidase 4 isoform X2

    Conserved Domains (2) summary
    pfam00930
    Location:102472
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    cl21494
    Location:553680
    Abhydrolase; alpha/beta hydrolases
  2. XM_006498692.3XP_006498755.1  dipeptidyl peptidase 4 isoform X3

    Conserved Domains (2) summary
    pfam00930
    Location:102472
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    cl21494
    Location:553679
    Abhydrolase; alpha/beta hydrolases
  3. XM_011239274.2XP_011237576.1  dipeptidyl peptidase 4 isoform X1

    Conserved Domains (2) summary
    pfam00930
    Location:102472
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    cl21494
    Location:553656
    Abhydrolase; alpha/beta hydrolases

RNA

  1. XR_001780739.1 RNA Sequence

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