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Dnpep aspartyl aminopeptidase [ Mus musculus (house mouse) ]

Gene ID: 13437, updated on 12-Feb-2024

Summary

Official Symbol
Dnpepprovided by MGI
Official Full Name
aspartyl aminopeptidaseprovided by MGI
Primary source
MGI:MGI:1278328
See related
Ensembl:ENSMUSG00000026209 AllianceGenome:MGI:1278328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable identical protein binding activity. Predicted to act upstream of or within proteolysis. Predicted to be located in cytosol. Orthologous to human DNPEP (aspartyl aminopeptidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine adult (RPKM 135.2), large intestine adult (RPKM 105.3) and 28 other tissues See more
Orthologs
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Genomic context

See Dnpep in Genome Data Viewer
Location:
1 C4; 1 38.71 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75285209..75294648, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75308565..75317654, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type N Neighboring gene regulated endocrine-specific protein 18 Neighboring gene VISTA enhancer mm1372 Neighboring gene desmin upstream regulatory region Neighboring gene predicted gene 15179 Neighboring gene desmin Neighboring gene SPEG complex locus

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
aspartyl aminopeptidase
NP_001104301.1
NP_001407066.1
NP_001407067.1
NP_001407068.1
NP_001407069.1
NP_001407070.1
NP_001407071.1
NP_001407072.1
NP_001407073.1
NP_001407074.1
NP_001407075.1
NP_058574.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110831.2NP_001104301.1  aspartyl aminopeptidase isoform a

    See identical proteins and their annotated locations for NP_001104301.1

    Status: VALIDATED

    Source sequence(s)
    AC166150
    Consensus CDS
    CCDS78623.1
    UniProtKB/TrEMBL
    Q3TVK3, Q3U3I6, Q8CAJ7
    Related
    ENSMUSP00000140864.2, ENSMUST00000185797.7
    Conserved Domains (1) summary
    pfam02127
    Location:24462
    Peptidase_M18; Aminopeptidase I zinc metalloprotease (M18)
  2. NM_001420137.1NP_001407066.1  aspartyl aminopeptidase isoform b

    Status: VALIDATED

    Source sequence(s)
    AC166150
    UniProtKB/Swiss-Prot
    Q56A00, Q9Z2W0
    UniProtKB/TrEMBL
    Q3U3I6, Q8CAJ7
  3. NM_001420138.1NP_001407067.1  aspartyl aminopeptidase isoform b

    Status: VALIDATED

    Source sequence(s)
    AC166150
    UniProtKB/Swiss-Prot
    Q56A00, Q9Z2W0
    UniProtKB/TrEMBL
    Q3U3I6, Q8CAJ7
  4. NM_001420139.1NP_001407068.1  aspartyl aminopeptidase isoform b

    Status: VALIDATED

    Source sequence(s)
    AC166150
    UniProtKB/Swiss-Prot
    Q56A00, Q9Z2W0
    UniProtKB/TrEMBL
    Q3U3I6, Q8CAJ7
  5. NM_001420140.1NP_001407069.1  aspartyl aminopeptidase isoform b

    Status: VALIDATED

    Source sequence(s)
    AC166150
    UniProtKB/Swiss-Prot
    Q56A00, Q9Z2W0
    UniProtKB/TrEMBL
    Q3U3I6, Q8CAJ7
  6. NM_001420141.1NP_001407070.1  aspartyl aminopeptidase isoform c

    Status: VALIDATED

    Source sequence(s)
    AC166150
    UniProtKB/TrEMBL
    Q3U3I6, Q8CAJ7
  7. NM_001420142.1NP_001407071.1  aspartyl aminopeptidase isoform d

    Status: VALIDATED

    Source sequence(s)
    AC166150
    UniProtKB/TrEMBL
    Q8CAJ7
  8. NM_001420143.1NP_001407072.1  aspartyl aminopeptidase isoform e

    Status: VALIDATED

    Source sequence(s)
    AC166150
    UniProtKB/TrEMBL
    Q3U3I6, Q8CAJ7
  9. NM_001420144.1NP_001407073.1  aspartyl aminopeptidase isoform f

    Status: VALIDATED

    Source sequence(s)
    AC166150
    UniProtKB/TrEMBL
    Q3U3I6, Q8CAJ7
  10. NM_001420145.1NP_001407074.1  aspartyl aminopeptidase isoform f

    Status: VALIDATED

    Source sequence(s)
    AC166150
    UniProtKB/TrEMBL
    Q3U3I6, Q8CAJ7
  11. NM_001420146.1NP_001407075.1  aspartyl aminopeptidase isoform g

    Status: VALIDATED

    Source sequence(s)
    AC166150
  12. NM_016878.5NP_058574.3  aspartyl aminopeptidase isoform b

    See identical proteins and their annotated locations for NP_058574.3

    Status: VALIDATED

    Source sequence(s)
    AC166150
    Consensus CDS
    CCDS15070.1
    UniProtKB/Swiss-Prot
    Q56A00, Q9Z2W0
    UniProtKB/TrEMBL
    Q3U3I6, Q8CAJ7
    Related
    ENSMUSP00000109235.4, ENSMUST00000113605.10
    Conserved Domains (1) summary
    cd05658
    Location:16461
    M18_DAP; M18 peptidase aspartyl aminopeptidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    75285209..75294648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)