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POC5 POC5 centriolar protein [ Homo sapiens (human) ]

Gene ID: 134359, updated on 8-Dec-2018

Summary

Official Symbol
POC5provided by HGNC
Official Full Name
POC5 centriolar proteinprovided by HGNC
Primary source
HGNC:HGNC:26658
See related
Ensembl:ENSG00000152359 MIM:617880
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C5orf37
Expression
Broad expression in testis (RPKM 10.4), lymph node (RPKM 4.7) and 24 other tissues See more
Orthologs

Genomic context

See POC5 in Genome Data Viewer
Location:
5q13.3
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (75674198..75717488, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (74970023..75013313, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene DNA polymerase kappa Neighboring gene RNA, U7 small nuclear 175 pseudogene Neighboring gene ankyrin repeat and death domain containing 1B Neighboring gene uncharacterized LOC107986424 Neighboring gene RNA, U6 small nuclear 680, pseudogene Neighboring gene uncharacterized LOC441087 Neighboring gene solute carrier family 25 member 5 pseudogene 9 Neighboring gene karyopherin subunit alpha 7 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35779, MGC120442, MGC120443, MGC120444

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centriole IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
centrosomal protein POC5
Names
POC5 centriolar protein homolog
hPOC5
protein of centriole 5
proteome of centriole 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099271.1NP_001092741.1  centrosomal protein POC5 isoform 1

    See identical proteins and their annotated locations for NP_001092741.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC010695, BJ991592, CA441610
    Consensus CDS
    CCDS47236.1
    UniProtKB/Swiss-Prot
    Q8NA72
    Related
    ENSP00000410216.2, ENST00000428202.6
    Conserved Domains (1) summary
    PRK14951
    Location:403537
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
  2. NM_152408.2NP_689621.2  centrosomal protein POC5 isoform 2

    See identical proteins and their annotated locations for NP_689621.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a unique start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    BC101327, CA441610, DB448626
    Consensus CDS
    CCDS47237.1
    UniProtKB/Swiss-Prot
    Q8NA72
    Related
    ENSP00000399481.2, ENST00000446329.6
    Conserved Domains (1) summary
    cl26386
    Location:378512
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    75674198..75717488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543158.2XP_011541460.1  centrosomal protein POC5 isoform X3

    Conserved Domains (1) summary
    PHA03247
    Location:403496
    PHA03247; large tegument protein UL36; Provisional
  2. XM_005248436.1XP_005248493.1  centrosomal protein POC5 isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:192375
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK14951
    Location:376509
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
  3. XM_011543160.1XP_011541462.1  centrosomal protein POC5 isoform X4

    See identical proteins and their annotated locations for XP_011541462.1

    Related
    ENSP00000426796.1, ENST00000510798.5
    Conserved Domains (1) summary
    PRK14951
    Location:286420
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
  4. XM_011543159.1XP_011541461.1  centrosomal protein POC5 isoform X4

    See identical proteins and their annotated locations for XP_011541461.1

    Conserved Domains (1) summary
    PRK14951
    Location:286420
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
  5. XM_017009037.2XP_016864526.1  centrosomal protein POC5 isoform X2

  6. XM_017009040.2XP_016864529.1  centrosomal protein POC5 isoform X5

  7. XM_024454362.1XP_024310130.1  centrosomal protein POC5 isoform X6

  8. XM_024454363.1XP_024310131.1  centrosomal protein POC5 isoform X7

RNA

  1. XR_001741999.1 RNA Sequence

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