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CMBL carboxymethylenebutenolidase homolog [ Homo sapiens (human) ]

Gene ID: 134147, updated on 8-Jul-2021

Summary

Official Symbol
CMBLprovided by HGNC
Official Full Name
carboxymethylenebutenolidase homologprovided by HGNC
Primary source
HGNC:HGNC:25090
See related
Ensembl:ENSG00000164237 MIM:613379
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JS-1
Summary
CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).[supplied by OMIM, Apr 2010]
Expression
Biased expression in kidney (RPKM 81.9), duodenum (RPKM 43.0) and 10 other tissues See more
Orthologs
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Genomic context

See CMBL in Genome Data Viewer
Location:
5p15.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (10277595..10307902, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (10277707..10308014, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATP synthase c subunit lysine N-methyltransferase Neighboring gene chaperonin containing TCP1 subunit 5 Neighboring gene CRISPRi-validated cis-regulatory element chr5.702 Neighboring gene Sharpr-MPRA regulatory region 12783

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23617

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hydrolase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 

General protein information

Preferred Names
carboxymethylenebutenolidase homolog
Names
carboxymethylenebutenolidase homolog (Pseudomonas)
carboxymethylenebutenolidase-like (Pseudomonas)
NP_620164.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138809.4NP_620164.1  carboxymethylenebutenolidase homolog

    See identical proteins and their annotated locations for NP_620164.1

    Status: VALIDATED

    Source sequence(s)
    AC012640, BC001573, DA628493
    Consensus CDS
    CCDS3878.1
    UniProtKB/Swiss-Prot
    Q96DG6
    Related
    ENSP00000296658.3, ENST00000296658.4
    Conserved Domains (1) summary
    COG0412
    Location:30245
    DLH; Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    10277595..10307902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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