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OR2Y1 olfactory receptor family 2 subfamily Y member 1 [ Homo sapiens (human) ]

Gene ID: 134083, updated on 23-Nov-2023

Summary

Official Symbol
OR2Y1provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily Y member 1provided by HGNC
Primary source
HGNC:HGNC:14837
See related
Ensembl:ENSG00000174339 AllianceGenome:HGNC:14837
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR5-2
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR2Y1 in Genome Data Viewer
Location:
5q35.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (180739123..180740058, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (181295726..181296661, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180166123..180167058, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily AI member 1 pseudogene Neighboring gene RNA, U1 small nuclear 17, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180212035-180212946 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180212947-180213857 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180224505-180225006 Neighboring gene alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr5:180229118-180229825 and GRCh37_chr5:180229826-180230532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180231240-180231945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16773 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23771 Neighboring gene Sharpr-MPRA regulatory region 14850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16775 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16776 Neighboring gene long intergenic non-protein coding RNA 847 Neighboring gene ZFP62 zinc finger protein Neighboring gene hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA

Genomic regions, transcripts, and products

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
olfactory receptor 2Y1
Names
olfactory receptor OR5-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001657.1NP_001001657.1  olfactory receptor 2Y1

    See identical proteins and their annotated locations for NP_001001657.1

    Status: VALIDATED

    Source sequence(s)
    AB065676
    Consensus CDS
    CCDS34323.1
    UniProtKB/Swiss-Prot
    B9EIP1, Q6IFB1, Q8NGV0, Q96R16
    UniProtKB/TrEMBL
    A0A126GVA6
    Related
    ENSP00000312403.2, ENST00000307832.3
    Conserved Domains (2) summary
    pfam00001
    Location:41289
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:35304
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    180739123..180740058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    181295726..181296661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)