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Dmc1 DNA meiotic recombinase 1 [ Mus musculus (house mouse) ]

Gene ID: 13404, updated on 28-Feb-2023

Summary

Official Symbol
Dmc1provided by MGI
Official Full Name
DNA meiotic recombinase 1provided by MGI
Primary source
MGI:MGI:105393
See related
Ensembl:ENSMUSG00000022429 AllianceGenome:MGI:105393
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sgdp; Dmc1h; Lim15; Mei11
Summary
This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. In mouse, deficiency of this gene causes infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Expression
Biased expression in limb E14.5 (RPKM 2.8), testis adult (RPKM 2.6) and 11 other tissues See more
Orthologs
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Genomic context

See Dmc1 in Genome Data Viewer
Location:
15 E1; 15 37.79 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79445698..79489362, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79561497..79605159, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 4 Neighboring gene KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 Neighboring gene DEAD box helicase 17 Neighboring gene family with sequence similarity 227, member A Neighboring gene predicted gene, 30877 Neighboring gene chibby family member 1, beta catenin antagonist

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC151144

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent activity, acting on DNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP-dependent activity, acting on DNA ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA strand exchange activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA strand exchange activity IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA recombinase assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome organization involved in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in double-strand break repair involved in meiotic recombination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within gamete generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male meiosis I IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within male meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within oocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within oogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in reciprocal meiotic recombination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in strand invasion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in condensed nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lateral element IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
meiotic recombination protein DMC1/LIM15 homolog
Names
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination
disrupted meiotic cDNA 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278226.1NP_001265155.1  meiotic recombination protein DMC1/LIM15 homolog isoform 2

    See identical proteins and their annotated locations for NP_001265155.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons in the coding region compared to variant 1. The resulting protein (isoform 2) lacks an internal portion and is shorter, compared to isoform 1.
    Source sequence(s)
    AK076777, AK169570, AV451479
    Consensus CDS
    CCDS88806.1
    UniProtKB/TrEMBL
    A0A8C6GAH1, Q8C610
    Related
    ENSMUSP00000155228.2, ENSMUST00000229408.2
    Conserved Domains (3) summary
    TIGR02238
    Location:24283
    recomb_DMC1; meiotic recombinase Dmc1
    cd01123
    Location:101281
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam14520
    Location:2579
    HHH_5; Helix-hairpin-helix domain
  2. NM_010059.3NP_034189.1  meiotic recombination protein DMC1/LIM15 homolog isoform 1

    See identical proteins and their annotated locations for NP_034189.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK169570, AV451479, BC116767
    Consensus CDS
    CCDS27644.1
    UniProtKB/Swiss-Prot
    Q61880
    UniProtKB/TrEMBL
    A0A8C6GAH0, Q14AN8
    Related
    ENSMUSP00000023065.7, ENSMUST00000023065.8
    Conserved Domains (3) summary
    TIGR02238
    Location:24338
    recomb_DMC1; meiotic recombinase Dmc1
    cd01123
    Location:101336
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam14520
    Location:2579
    HHH_5; Helix-hairpin-helix domain

RNA

  1. NR_103477.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks five alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK169570, AV451479
    Related
    ENSMUST00000230011.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79445698..79489362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520407.4XP_006520470.1  meiotic recombination protein DMC1/LIM15 homolog isoform X1

    Conserved Domains (1) summary
    TIGR02238
    Location:24296
    recomb_DMC1; meiotic recombinase Dmc1
  2. XM_006520408.4XP_006520471.1  meiotic recombination protein DMC1/LIM15 homolog isoform X2

    Conserved Domains (1) summary
    TIGR02238
    Location:24282
    recomb_DMC1; meiotic recombinase Dmc1

RNA

  1. XR_004938790.1 RNA Sequence