U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dio1 deiodinase, iodothyronine, type I [ Mus musculus (house mouse) ]

Gene ID: 13370, updated on 8-Feb-2024

Summary

Official Symbol
Dio1provided by MGI
Official Full Name
deiodinase, iodothyronine, type Iprovided by MGI
Primary source
MGI:MGI:94896
See related
Ensembl:ENSMUSG00000034785 AllianceGenome:MGI:94896
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D1; 5DI; ITDI1; TXDI1
Summary
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Apr 2016]
Expression
Biased expression in liver adult (RPKM 54.1), kidney adult (RPKM 25.9) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Dio1 in Genome Data Viewer
Location:
4 C7; 4 50.18 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (107148662..107164365, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (107291465..107307168, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 42 Neighboring gene STARR-positive B cell enhancer ABC_E4642 Neighboring gene intraflagellar transport 25 Neighboring gene Yip1 domain family, member 1 Neighboring gene replication factor C (activator 1) 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_11024 Neighboring gene STARR-positive B cell enhancer ABC_E10245 Neighboring gene NDC1 transmembrane nucleoporin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC107659

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables selenium binding IDA
Inferred from Direct Assay
more info
PubMed 
enables thyroxine 5'-deiodinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thyroxine 5'-deiodinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables thyroxine 5'-deiodinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in amino acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hormone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in thyroid hormone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
type I iodothyronine deiodinase
Names
DIOI
type 1 DI
type-I 5'-deiodinase
NP_031886.3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007860.4NP_031886.3  type I iodothyronine deiodinase

    See identical proteins and their annotated locations for NP_031886.3

    Status: REVIEWED

    Source sequence(s)
    AL645723, BC089608
    Consensus CDS
    CCDS18436.1
    UniProtKB/Swiss-Prot
    Q05CY5, Q5FW63, Q61153
    UniProtKB/TrEMBL
    A0A0R4J110
    Related
    ENSMUSP00000081007.5, ENSMUST00000082426.11
    Conserved Domains (1) summary
    cl00388
    Location:8247
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    107148662..107164365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)