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Dhh desert hedgehog [ Mus musculus (house mouse) ]

Gene ID: 13363, updated on 8-Feb-2024

Summary

Official Symbol
Dhhprovided by MGI
Official Full Name
desert hedgehogprovided by MGI
Primary source
MGI:MGI:94891
See related
Ensembl:ENSMUSG00000023000 AllianceGenome:MGI:94891
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables patched binding activity. Acts upstream of or within several processes, including Leydig cell differentiation; male sex determination; and osteoblast differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including gonad; gut; heart and pericardium; nervous system; and yolk sac. Used to study 46,XY sex reversal. Human ortholog(s) of this gene implicated in 46,XY sex reversal and 46,XY sex reversal 7. Orthologous to human DHH (desert hedgehog signaling molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 10.4), testis adult (RPKM 4.0) and 7 other tissues See more
Orthologs
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Genomic context

See Dhh in Genome Data Viewer
Location:
15 F1; 15 55.05 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98779496..98796443, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98881615..98898562, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98663163-98663346 Neighboring gene lysine (K)-specific methyltransferase 2D Neighboring gene STARR-seq mESC enhancer starr_39676 Neighboring gene STARR-positive B cell enhancer ABC_E10880 Neighboring gene Ras homolog enriched in brain like 1 Neighboring gene limb region 1 like Neighboring gene STARR-positive B cell enhancer mm9_chr15:98748573-98748874 Neighboring gene predicted gene, 41396 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98764367-98764476 Neighboring gene tubulin, alpha 1B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC73610

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables patched binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables patched binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables patched binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Leydig cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within Leydig cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Schwann cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in intein-mediated protein splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male sex determination IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in paracrine signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoprocessing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of steroid biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within smoothened signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
desert hedgehog protein
Names
HHG-3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007857.5NP_031883.1  desert hedgehog protein preproprotein

    See identical proteins and their annotated locations for NP_031883.1

    Status: VALIDATED

    Source sequence(s)
    AC161165, AK032466, AK033392
    Consensus CDS
    CCDS27810.1
    UniProtKB/Swiss-Prot
    Q61488
    UniProtKB/TrEMBL
    Q544P6
    Related
    ENSMUSP00000023737.5, ENSMUST00000023737.6
    Conserved Domains (2) summary
    pfam01079
    Location:188395
    Hint; Hint module
    pfam01085
    Location:40185
    HH_signal; Hedgehog amino-terminal signalling domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    98779496..98796443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520406.5XP_006520469.1  desert hedgehog protein isoform X1

    Conserved Domains (2) summary
    pfam01079
    Location:74281
    Hint; Hint module
    pfam01085
    Location:171
    HH_signal; Hedgehog amino-terminal signalling domain

RNA

  1. XR_875235.3 RNA Sequence